A5103211042- Vehicle License Plate Recognition
- RNA modifications and cancer
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- Micro and Nano Robotics
- Glycosylation and Glycoproteins Research
- Retinoids in leukemia and cellular processes
- 3D Printing in Biomedical Research
- Advanced SAR Imaging Techniques
- Blood properties and coagulation
- Carbohydrate Chemistry and Synthesis
- Cancer therapeutics and mechanisms
- PAPR reduction in OFDM
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Power Line Inspection Robots
- Caveolin-1 and cellular processes
- Automated Road and Building Extraction
- Advanced MRI Techniques and Applications
- Handwritten Text Recognition Techniques
- Cancer-related gene regulation
- Blind Source Separation Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Heat shock proteins research
Beijing University of Chinese Medicine
2024
Peking University
2018-2024
Nanchang University
2024
Molecular Oncology (United States)
2024
State Key Laboratory of Molecular Oncology
2024
Peking University International Hospital
2022-2024
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate cells encounter different mechanical cues both health and disease adapt their behaviors. However, impact of sensing signals on signal-mediated remains unclear. Here we show that signalling augments macrophage bactericidal activity through sensor Piezo1. Bacterial infection or LPS stimulation triggers assembly complex Piezo1 remodel F-actin organization augment phagocytosis, mitochondrion-phagosomal...
Abstract The folded mitochondria inner membrane-cristae is the structural foundation for oxidative phosphorylation (OXPHOS) and energy production. By mechanically simulating morphogenesis, we speculate that efficient sculpting of cristae organelle non-autonomous. It has long been inferred folding requires buckling in living systems. However, tethering force formation regulation not identified. Combining electron tomography, proteomics strategies, super resolution live cell imaging...
Epithelial cell transforming 2 (Ect2) protein activates Rho GTPases and controls cytokinesis many other cellular processes. Dysregulation of Ect2 is associated with various cancers. Here, we report the crystal structure human complementary mechanistic analyses. The data show C-terminal PH domain folds back blocks canonical RhoA-binding site at catalytic center DH domain, providing a mechanism autoinhibition. activated by binding GTP-bound RhoA to which suggests an allosteric activation...
This paper introduces a novel finite Zak transform (FZT)-aided framework for constructing multiple zero-correlation zone (ZCZ) sequence sets with optimal correlation properties. Specifically, each is perfect zero auto-correlation sidelobes, ZCZ set meets the Tang-Fan-Matsufuji bound equality, and maximum inter-set cross-correlation of Sarwate equality. Our study shows that these sequences can be sparsely expressed in domain through properly selected index phase matrices. Particularly, it...
Secondary systems in electrical engineering often rely on traditional CAD software (AutoCAD v2024.1.6) or non-structured, paper-based diagrams for fieldwork, posing challenges digital transformation. Electrical diagram recognition technology bridges this gap by converting operations into a “digital” model, playing critical role power system scheduling, operation, and maintenance. However, conventional methods, which primarily partition detection, face significant limitations such as poor...
Pure laparoscopic liver resection (PLLR) has been reported to be as safe and effective open (OLR) for lesions, it is associated with less intraoperative blood loss, shorter hospital stay, lower complication rate. However, studies comparing PLLR OLR in elderly patients were limited. The aim of this study was analyze the short-term outcome versus primary carcinoma (PLC) patients. Between January 2008 October 2014, 30 consecutive (≥70 years) who underwent PLC included into analysis. Sixty...
Abstract Epithelial ovarian cancer (EOC) is one of the leading causes death from gynecologic cancers and peritoneal dissemination major cause in patients with EOC. Although loss 4.1N associated increased risk malignancy, its association EOC remains unclear. To explore underlying mechanism constitutive activation epithelial-mesenchymal transition (EMT) matrix-detached cell resistance, we investigated samples 268 formalin-fixed tissues performed various vitro vivo assays. We report that...
Phase separation is an important mechanism that mediates the spatial distribution of proteins in different cellular compartments. While phase-separated share certain sequence characteristics, including intrinsically disordered regions (IDRs) and prion-like domains, such characteristics are insufficient for making accurate predictions; thus, a proteome-wide understanding phase currently lacking. Here, we define proteomes based on systematic analysis immunofluorescence images 12 073 Human...
The matching of schematic diagrams and physical information terminal blocks in substation secondary screen cabinets plays a crucial role the operation maintenance substations. To enhance automation level this task reduce labor costs, method for identifying based on artificial intelligence is investigated paper. Initially, multi-layer object detection networks, tailored to characteristics both entities cabinets, are designed precise extraction information. Subsequently, network topologies...
KH-1 antigen core nonasaccharide was efficiently assembled by photo-induced glycosylation.
Cell migration towards stiff substrates has been coined as durotaxis and implicated in development, wound healing, cancer, where complex interplays between immune non-immune cells are present. Compared to the emerging mechanisms underlying strongly adhesive mesenchymal durotaxis, little is known about whether - migrating amoeboid mode could follow mechanical cues. Here, we develop an imaging-based confined device with a stiffness gradient. By tracking live cell trajectory analyzing...
Despite the continuous advancement of intelligent power substations, terminal block components within equipment cabinet inspection work still often require loads personnel. The repetitive documentary works not only lack efficiency but are also susceptible to inaccuracies introduced by substation To resolve problem lengthy, time-consuming inspections, a component detection and identification method is presented in this paper. multi-stage system that incorporates streamlined version You Only...
Abstract Cells exist in highly crowded environments where they are exposed to fluctuating mechanical forces arising from surrounding cells and the extracellular matrix microenvironment. In these settings, external transmitted intracellular organelles including nucleus. While can survive confinement, extended duration of confinement or settings unable escape, result cell death. How sense respond prolonged trigger death remains unclear. Here, we demonstrate that nuclear deformation generated...
To investigate the effects of different concentrations adapalene on morphology and functions neuroblastoma cell line SH-SY5Y, as well its role in inducing differentiation apoptosis.
Cell migration towards stiff substrates has been coined as durotaxis and implicated in development, wound healing, cancer, where complex interplays between immune non-immune cells are present. Compared to the emerging mechanisms underlying strongly adhesive mesenchymal durotaxis, little is known about whether - migrating amoeboid mode could follow mechanical cues. Here, we develop an imaging-based confined device with a stiffness gradient. By tracking live cell trajectory analyzing...
Abstract Intrinsically disordered region (IDR) analysis has been widely used in the screening of phase-separated proteins. However, precise sequences determining phase separation remain unclear. Furthermore, a large number proteins that exhibit relatively low IDR content uncharacterized. Phase-separated appear as spherical droplet structures immunofluorescence (IF) images, which renders them distinguishable from non-phase-separated Here, we transformed problem protein recognition into binary...