A5052814656- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Preterm Birth and Chorioamnionitis
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Pregnancy and preeclampsia studies
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Esophageal and GI Pathology
- Endometriosis Research and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Management of metastatic bone disease
- Dental Radiography and Imaging
- Hydraulic and Pneumatic Systems
Osaka International Cancer Institute
2016-2025
Osaka International University
2020
Osaka University
2015
Hamamatsu University School of Medicine
1997
OBJECTIVES: The reported 1- and 3-year overall survival rates after esophagectomy for stage I superficial esophageal squamous cell carcinoma (SESCC) are 95–97% 86%, those definitive chemoradiotherapy (CRT) 98% 89%, respectively. This study was performed to elucidate the efficacy safety of another treatment option SESCC: endoscopic resection (ER) followed by CRT. METHODS: We retrospectively reviewed survival, recurrence, grade ≥3 adverse events consecutive patients who refused underwent ER...
A novel linac-bases radiosurgery (SRS) system, HyperArc, applied to the non-coplanar volume-modulated arc therapy (VMAT) technique, was developed and released in clinical practice. The aim of study evaluate dosimetric performance brain sparing single-target three-target cases, for two types SRS systems: GammaKnife HyperArc. total 83 patients treated with (35 single, 24 double, triple metastases) were retrospectively analyzed. Treatment plans recalculated using Dosimetric parameters,...
Abstract Background Fractionated stereotactic radiosurgery (fSRS) is an important treatment strategy for unresected brain metastases. We previously reported that a good volumetric response 6 months after fSRS can be the first step local control. Few studies have association between gross tumor volume (GTV) dose, response, and control in patients treated with same number of fractions. Therefore, this study, we aimed to investigate GTV dose five daily fractions identify predictive failure (LF)...
Abstract Purpose This study investigated the intra‐fractional motion (IM) of patients immobilized using QFix Encompass Immobilization System during HyperArc (HA) treatment. Method HA treatment was performed on 89 Encompass. The IM (including megavoltage (MV) registration) analyzed for six degrees freedom including three axes translation (anterior‐posterior, superior‐inferior (SI) and left‐right (LR)) rotation (pitch, roll, yaw). Then, no corrected (IM NC ) retrospectively simulated...
Abstract Background and Purpose Few reports include volumetric measurements as endpoints after stereotactic radiotherapy (SRT) despite the importance of such measurements. This study aimed to (1) investigate impact response (specifically, an over 65% 90% volume reduction in brain metastases) at 6 months post‐SRT on local control (2) identify predictive factors for a 90%. Materials Methods included 250 unresected metastases (>0.3 cc) treated with SRT. Doses were stratified according...
Abstract Purpose To compare the intrafractional motion error (IME) during stereotactic irradiation (STI) in patients with brain metastases immobilized using open‐ (Encompass) and full‐face (DSPS) clamshell‐style immobilization devices. Methods Encompass (38 patients) DSPS were used for patient immobilization, HyperArc plans three to four non‐coplanar beams generated deliver 25 35 Gy five fractions. Cone‐beam computed tomography (CBCT) was performed on before after treatment. Moreover,...
Dosimetric parameters in volumetric modulated arc therapy (VMAT), non-coplanar VMAT (NC-VMAT), and automated NC-VMAT (HyperArc, HA) were compared for patients with maxillary sinus carcinoma (MSC).Twenty HA plans generated to deliver 70.4, 64, 46 Gy planning target volumes high (PTV1), intermediate (PTV2), low risk (PTV3), respectively. The retrospectively using the same optimized as those used plans.For PTV1, three treatment provided comparable coverages. For PTV2, D95%, D99%, Dmin...
Introduction: Several studies have reported the relation between imaging dose and secondary cancer risk emphasized need to minimize additional as low reasonably achievable. The iterative cone-beam computed tomography (iCBCT) algorithm can improve image quality by utilizing scatter correction statistical reconstruction. We investigate use of a novel iCBCT reconstruction reduce patient while maintaining low-contrast detectability registration accuracy. Methods: Catphan anthropomorphic phantoms...
Abstract The prognosis of hepatocellular carcinoma (HCC) with portal vein tumour thrombus (PVTT) is poor. We conducted a prospective study to evaluate the efficacy and safety tri-modality therapy, including preoperative stereotactic body radiotherapy (SBRT) surgery, followed by hepatic arterial infusion chemotherapy (HAIC) in HCC patients PVTT. In this report, we investigated pathology irradiated PVTT specimen resected cases SBRT-related acute toxicity. A total 8 received SBRT targeting at...
Background/Aim: To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) concomitant boost technique. Patients Methods: A total 159 who underwent AH-CCRT (64 Gy 40 fractions twice daily) were retrospectively identified. Severe RE was designated as grade 3 or higher according to Common Terminology Criteria for Adverse Events,...
The purpose of this study was to determine the outcomes and optimal practice patterns definitive radiotherapy for primary vaginal cancer. Between 1993 2012, 49 patients were treated with cancer in three hospitals. Of these, 15 (31%) had clinically positive regional lymph node metastasis. A total 34 (70%) received external beam high-dose-rate brachytherapy (interstitial or intracavitary), 8 (16%) (with small superficial Stage I tumors) local radiotherapy. median follow-up 33 months (range:...
Abstract Background This study evaluated the locations of lymph node recurrence and their association with irradiation fields used for radiotherapy after adjuvant chemoradiotherapy following endoscopic resection superficial esophageal squamous cell carcinoma. Methods Medical records 96 consecutive patients carcinoma who underwent were reviewed. Computed tomography was to identify whether nodal recurrences within elective field. The cumulative incidence calculated, accounting death as a...
Background/Aim: To assess the impact of width multileaf collimator (MLC) on dose distributions HyperArc fractionated stereotactic irradiation for multiple (5-10) brain metastases. Patients and Methods: Twenty-one (HA) plans were generated using high definition (HD) MLC (2.5 mm) to deliver 30-35 Gy in 3-5 fractions (HA-HD). The Millennium (ML) (5 retrospectively (HA-ML) same planning parameters with HA-HD. Dosimetric between target volume (PTV) organs at risk (OARs) compared. Results:...
This study introduced an A-mode portable ultrasound bladder scanner, the Lilium® α-200 (here after Lilium; Lilium Otsuka, Kanagawa, Japan), for treatment of prostate cancer patients with hypofractionated volumetric modulated arc therapy to improve reproducibility volume (BV).Thirty were advised maintain full BV prior computed tomography (CT) simulation and daily treatment. Among these, 15 was measured using until a 80% in achieved (with group). Daily cone-beam CT (CBCT) performed The...
Determination of the optimal energy level virtual monochromatic image (VMI) for brain metastases in contrast-enhanced dual-energy CT (DECT) radiosurgery and assessment subjective objective quality VMI at level.20 patients (total 42 metastases) underwent DECT. Spectral analysis VMIs levels ranging from 40 to 140 keV 1 increments was performed determine (VMIopt) as one corresponding highest contrast-to-noise ratio (CNR) between parenchyma metastases. The values VMIopt were compared those with...
Background/Aim: The aim of this retrospective study was to detect the frequency, reasons, and significant factors for not receiving immunotherapy after chemoradiotherapy in non-small cell lung cancer (NSCLC) patients. Patients Methods: Thirty-four patients with NSCLC received definitive chemoradiotherapy. endpoint durvalumab within 45 days NSCLC. Results: Twenty-five 34 (73%) reasons were radiation pneumonitis (50%), esophagitis (10%), four other (40%). Univariate analysis showed that...
Abstract The immobilization of patients with a bite block (BB) carries the risk interpersonal infection, particularly in context pandemics such as COVID-19. Here, we compared intra-fractional patient setup error (intra-SE) and without BB during fractionated intracranial stereotactic irradiation (STI). Fifteen brain metastases were immobilized using medical mask, while 15 mask. intra-SEs six directions (anterior–posterior (AP), superior–inferior (SI), left–right (LR), pitch, roll, yaw)...
Aim: To identify clinical benefits of dose escalation in accelerated hyperfractionated radiotherapy (AH-RT) for stage III non-small-cell lung cancer (NSCLC) using propensity score-matched (PSM) analysis. Materials and Methods: Our study retrospectively examined 294 patients undergoing definitive [131 patients, conventional once-daily (OD-RT); 163, AH-RT] who were followed-up a median 40.4 months. The impact overall survival (OS), progression-free (PFS), locoregional control (LRC) was...
The incidence of hypopharyngeal and supraglottic cancer (HSC) is high in Japan. This study aimed to retrospectively identify risk factors for death unrelated from aspiration pneumonia after definitive radiotherapy (RT) HSC.Overall, 391 patients who began RT HSC between 2006 2014 were identified the Osaka International Cancer Institute electronic database. Among patients, 33 had a history surgery esophageal (EC) 19 received simultaneous synchronous EC. cause was divided into 3 main...
The objective of this study was to assess the accuracy quantitative measurements obtained using dual-energy computed tomography with metal artifact reduction software (MARS).Dual-energy scans (fast kV-switching) are performed on a phantom, by varying number rods (Ti and Pb) reference iodine materials. Objective subjective image analyses retroreconstructed virtual monochromatic images (VMIs) (VMI at 70 keV).The maximum indices for VMI-Ti VMI-Pb (5 rods) MARS (without MARS) were 17.4 (166.7)...