A5042005913- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Medical Image Segmentation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Fetal and Pediatric Neurological Disorders
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammatory Bowel Disease
- Bone and Joint Diseases
- Advanced Neural Network Applications
- Alzheimer's disease research and treatments
- Microscopic Colitis
- Brain Tumor Detection and Classification
- Medical Imaging and Analysis
- Hearing Loss and Rehabilitation
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Adversarial Robustness in Machine Learning
- Cerebral Palsy and Movement Disorders
- Glioma Diagnosis and Treatment
Age UK
2019-2025
Erasmus MC
2013-2024
Borland Groover Clinic
2024
King's College London
2016-2024
Wellcome Centre for Human Neuroimaging
2024
GlaxoSmithKline (United Kingdom)
2019-2023
Erasmus University Rotterdam
2012-2021
Delft University of Technology
2008-2020
GlaxoSmithKline (India)
2020
Cambridge University Hospitals NHS Foundation Trust
2019
Background and Purpose— It is unknown whether white matter lesions (WML) develop abruptly in previously normal brain areas, or tissue changes are already present before WML become apparent on MRI. We therefore investigated development of preceded by quantifiable normal-appearing (NAWM). Methods— In 689 participants from the general population (mean age 67 years), we performed 2 MRI scans (including diffusion tensor imaging Fluid Attenuation Inversion Recovery [FLAIR] sequences) 3.5 years...
Anatomical alignment in neuroimaging studies is of such importance that considerable effort put into improving the registration used to establish spatial correspondence. Tract-based statistics (TBSS) a popular method for comparing diffusion characteristics across subjects. TBSS establishes correspondence using combination nonlinear and "skeleton projection" may break topological consistency transformed brain images. We therefore investigated feasibility replacing two-stage...
Loss of brain white matter microstructure is presumed to be an early sign neurodegenerative disease. Yet, little known on microstructural changes various tracts with normal aging.In 4532 nondemented elderly persons, we studied age-related in tract-specific diffusion characteristics for 25 using probabilistic tractography. We how differs across aging, whether this depends macrostructural changes, and cardiovascular risk factors affect microstructure.With increasing age, loss organization...
With aging, the brain undergoes several structural changes. These changes reflect normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these is an important cornerstone to also disentangle pathologic Several studies have investigated both cross-sectional longitudinal, focused on a broad range magnetic resonance imaging (MRI) markers. This study aims comprise different aspects in by performing comprehensive longitudinal assessment providing...
Objectives To date, only four small studies have investigated the effects of adjuvant chemotherapy for breast cancer on microstructure cerebral white matter with magnetic resonance imaging (MRI). These studies, which were conducted shortly up to 10 years post‐treatment, showed that is associated focal loss microstructural integrity. We long‐term effect integrity by comparing brains chemotherapy‐exposed survivors those a population‐based sample women without history cancer. Experimental...
To determine longitudinally the rate of change in diffusion-tensor imaging (DTI) parameters white matter microstructure with aging and to investigate whether cardiovascular risk factors influence this longitudinal change.This prospective population-based cohort study was approved by a dedicated ethics committee overseen national government, all participants gave written informed consent. Community-dwelling without dementia were examined using research-dedicated 1.5-T magnetic resonance (MR)...
White matter microstructural integrity has been related to cognition. Yet, the potential role of specific white tracts on top a global effect remains unclear, especially when considering cognitive domains. Therefore, we determined tract-specific microstructure cognition and In 4400 nondemented stroke-free participants (mean age 63.7 years, 55.5% women), obtained diffusion magnetic resonance imaging parameters (fractional anisotropy mean diffusivity) in 14 using probabilistic tractography...
To investigate the added diagnostic value of arterial spin labelling (ASL) and diffusion tensor imaging (DTI) to structural MRI for computer-aided classification Alzheimer's disease (AD), frontotemporal dementia (FTD), controls.This retrospective study used data from 24 early-onset AD 33 FTD patients 34 controls (CN). Classification was based on voxel-wise feature maps derived MRI, ASL, DTI. Support vector machines (SVMs) were trained classify versus CN (AD-CN), FTD-CN, AD-FTD, AD-FTD-CN...
Abstract Microstructural white matter deterioration is a frequent finding in mild cognitive impairment (MCI), potentially underlying default mode network (DMN) dysfunctioning. Thus far, microstructural damage MCI has been attributed to Alzheimer's disease pathophysiology. A cerebrovascular role, particular the role of cerebral small vessel (CSVD), received less interest. Here, we used diffusion tensor imaging (DTI) examine CSVD within normal appearing (NAWM) MCI. patients were subdivided...
To investigate whether the presence of cerebral microbleeds, which present as focal lesions on imaging, is associated with a diffuse loss white matter microstructural integrity in brain.In prospective, population-based Rotterdam Scan Study, total 4,493 participants underwent brain MRI to determine microbleed status. With diffusion tensor global fractional anisotropy (FA) and mean diffusivity (MD) were measured normal-appearing matter. Multiple linear regression models, adjusted for age, sex,...
Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- interrater variability. Automated rating may benefit biomedical research, as well clinical assessment, diagnostic reliability existing algorithms unknown. Here, we present the results VAscular Lesions DetectiOn Segmentation (Where VALDO?) challenge that was run a satellite event at international conference Medical...
Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations more detail, it is highly important that the WM tracts can be accurately reproducibly characterized from brain diffusion MRI. In addition, to enable analysis of large datasets clinical practice essential methodology fast easy apply. This work therefore presents a new approach for tract segmentation: Neuro4Neuro, capable direct extraction tensor images...
Abstract Molecular neuroimaging techniques, like PET and SPECT, offer invaluable insights into the brain’s in-vivo biology its dysfunction in neuropsychiatric patients. However, transition of molecular diagnostics precision medicine has been limited to a few clinical applications, hindered by issues practical feasibility, high costs, between-subject heterogeneity measures. In this study, we explore use normative modelling (NM) identify individual patient alterations describing physiological...
To investigate the association of kidney function with white matter microstructural integrity.We included 2,726 participants a mean age 56.6 years (45% men) from population-based Rotterdam Study. Albumin-to-creatinine ratio, and estimated glomerular filtration rate (eGFR), using serum cystatin C (eGFRcys) creatinine (eGFRcr), were measured to evaluate function. Diffusion-MRI was used assess integrity normal-appearing matter. Multiple linear regression models, adjusted for macrostructural MRI...
Diminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer's disease (AD). It hypothesized that stage AD, PCC functioning relates to or reflects hippocampal dysfunction atrophy. The aim this study was examine relationship between hippocampus function, volume and structural connectivity, activation during an episodic memory task-related fMRI mild cognitive impairment (MCI).MCI patients (n = 27) underwent fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI diffusion...
To investigate whether retinal microvascular damage is related to normal-appearing white matter microstructure on diffusion tensor MRI.We included 2,436 participants (age ≥45 years) from the population-based Rotterdam Study (2005-2009) who had gradable images and brain MRI scans. Retinal arteriolar venular calibers were measured semiautomatically fundus photographs. White was assessed using MRI. We used linear regression models associations of vascular with markers microstructure, adjusting...