A5101774650- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- MicroRNA in disease regulation
- Protein purification and stability
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Chromatography
- Neurogenesis and neuroplasticity mechanisms
- Coronary Interventions and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Function and Risk Factors
- Neuropeptides and Animal Physiology
- Hepatitis B Virus Studies
- Cardiac Ischemia and Reperfusion
- Prenatal Substance Exposure Effects
- Viral Infectious Diseases and Gene Expression in Insects
- Mycobacterium research and diagnosis
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Autophagy in Disease and Therapy
- Advanced Synthetic Organic Chemistry
University of Nottingham Ningbo China
2024
Northwest University
2016-2024
Air Force Medical University
2022-2024
Zhongshan Hospital
2021-2022
Fudan University
2021-2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
Ningbo University
2019-2020
Ningbo Medical Center Lihuili Hospital
2020
Second Affiliated Hospital of Harbin Medical University
2008-2018
To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma patients with congenital heart diseases (CHDs).qRT-PCR was used to detect HOTAIR right atrial appendage 16 CHDs 14 rheumatic valvular (RVHDs), as well 36 normal people 90 including cases ASD, 23 VSD, 31 PDA. Besides, proteins interacting were obtained from databases.The group significantly higher than that RVHDs (P < 0.01). Compared control group, ASD VSD PDA all remarkably upregulated 0.01),...
Abstract Ca 2+ signaling is essential for oligodendrocyte (OL) development and myelin formation. Inositol 1,4,5‐trisphosphate receptor type 2 (ITPR2) an endoplasmic reticulum calcium channel shows stage‐dependent high levels in postmitotic precursor cells (OPCs). The role potential mechanism of ITPR2 OLs remain unclear. In this study, it revealed that loss Itpr2 disturbs homeostasis inhibits myelination adolescent mice. Animals with OL‐specific deletion exhibit anxiety/depressive‐like...
A variety of neurological and psychiatric disorders have recently been shown to be highly associated with the abnormal development function oligodendrocytes (OLs) interneurons. OLs are myelin-forming cells in central nervous system (CNS), while interneurons important neural types gating excitatory neurons. These two great significance for establishment circuits, they share similar developmental origins transcriptional architectures, interact each other multiple ways during development. In...
The transfer and development of chronic hepatitis B virus (HBV) infection is associated with the T cell immune response, therefore investigating key regulators response needed to improve HBV treatment. Blood samples from patients were used confirm correlation between stage CD160 receptor expression levels in CD8+ cells, cells are research mechanism modulation, moreover, C3H/HeN mice reduced investigate association long non-coding (lnc)RNA-CD160 infection. Long histone-modification enzyme...
The cytoskeleton serves an important role in maintaining cellular morphology and function, it is a substrate of calpain during myocardial ischemia/reperfusion (I/R) injury (MIRI). Calpain may be activated by endoplasmic reticulum (ER) stress MIRI. activation peroxisome proliferator‑activated receptor α (PPARα) inhibit damage regulating reactions. present study aimed to determine whether the PPARα protects against MIRI‑induced cytoskeletal degradation, investigated underlying mechanism...
Background Estrogen‐related receptor gamma ( ESRRG ) has been identified as a tumor suppressor gene in several cancers. We aimed to evaluate promoter methylation laryngeal squamous cell carcinoma (LSCC) and its relative clinical value LSCC. Methods Bisulfite pyrosequencing assays were performed on 91 pairs of paracancer tissues from LSCC patients China. The diagnostic overall survival (OS) analyzed descriptively by receiver operating characteristic (ROC) curves the Kaplan‐Meier methods,...
Abstract Protein‐folding liquid chromatography (PFLC) is an effective and scalable method for protein renaturation with simultaneous purification. However, it has been a challenge to fully refold inclusion bodies in PFLC column. In this work, refolding purification of recombinant human proinsulin (rhPI) from Escherichia coli were investigated using the surface stationary phases immobilized metal ion affinity (IMAC) high‐performance size‐exclusion (HPSEC). The results indicated that both...
In this work, based on the structural characteristics of bio‐membrane molecules, a novel type high‐performance hydrophobic interaction chromatography stationary phase was prepared using cholesterol as ligand. Investigating separation performance phase, effect pH and salt concentration mobile retention time, absorption capacity, ability revealed that had high loading capacity moderate interactions compared with four different ligands. Five types standard proteins could be baseline separated...
Background: Coronary chronic total occlusion (CTO) disease is common and its specific characteristic collateral formation. The Integrated analysis of angiogenesis related lncRNA-miRNA-mRNA network remains unclear might provide target for future studies. Methods: A five coronary artery (control group) CTO (CTO patients were selected deep RNA miRNA sequencing. expression profiles lncRNAs, mRNAs circRNA miRNAs obtained. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway...
After the expression level of lncRNA AC023794.4-201 was upregulated in 2 laryngeal squamous cell carcinoma (LSCC) lines (AMC-HN-8 and TU-212) LSCC xenografts, biological function further investigated using vitro vivo experiments, such as experiments nude mice transplantation. In our previous study, it demonstrated that long non-coding RNA (lncRNA) were decreased carcinoma, particularly cases with lymphatic metastasis. Moreover, low levels revealed to be an adverse prognostic factor for...
Abstract How miRNAs play a role in collateral formation of chronic total occlusion (CTO) patients and predicting myocardial perfusion has not been investigated. In this study, we screened circulating CTO stable coronary artery disease using high-throughput sequencing found 42 differential expressed miRNAs, including miR-329, miR-494 miR-495, which belong to 14q32 gene cluster. The down regulation miR-495 was confirmed an independently larger cohort. Then vitro vivo demonstrated that...
Objective To investigate the protective effects and molecular mechanism of peroxisome proliferate-activated receptor α(PPARα) activation on acute myocardial damage induced by isoproterenol (Iso) in rats. Methods Thirty male Wistar rats, weighting 160～180 g, were randomly divided into control group, Iso fenafibrate(FF) group(each n=10) according to physique quantity. Acute injury caused abdomen cavity injection ischemia was established α accessed level ereatine kinase(CK), lactic...
Abstract Background: Lung adenocarcinoma (LUAD) usually contain heterogeneous histological subtypes, among which the micropapillary (MIP) subtype was associated with poor prognosis while lepidic (LEP) possessed most favorable outcome. A more comprehensive analysis involving discovery and public validation cohorts on two subtypes could better decipher key biological evolutionary mechanisms. Methods: We firstly retrospectively studied survival status of 286 LUAD patients different subtypes....