A5012588685- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Urinary Bladder and Prostate Research
- Genetic Associations and Epidemiology
- Cardiovascular Syncope and Autonomic Disorders
- Respiratory and Cough-Related Research
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Diagnosis and Treatment
- Delphi Technique in Research
- Epigenetics and DNA Methylation
- Pelvic floor disorders treatments
- Respiratory Support and Mechanisms
- Urological Disorders and Treatments
- Gynecological conditions and treatments
- Nutrition, Genetics, and Disease
- Forensic Toxicology and Drug Analysis
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- HIV, Drug Use, Sexual Risk
- Pancreatic function and diabetes
- Cardiac Arrhythmias and Treatments
- Folate and B Vitamins Research
- Cystic Fibrosis Research Advances
- HIV/AIDS Research and Interventions
Broad Institute
2024
GlaxoSmithKline (Spain)
2011-2020
GlaxoSmithKline (United Kingdom)
2013-2016
Abstract Background Current asthma management guidelines are based on the level of control. The impact control health care resources and quality life (QoL) is insufficiently studied. EUCOAST study was designed to describe costs QoL in adult patients according France Spain. Methods An observational cost illness conducted simultaneously both countries among age greater or equal 18 with a diagnosis for at least 12 months. Patients were recruited prospectively by GPs 2010 four waves avoid...
Abstract Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for special challenges studies admixed populations. Here, we present admix-kit, an integrated toolkit pipeline analyses Admix-kit implements a suite methods to facilitate genotype phenotype simulation,...
To determine generic utilities for Spanish chronic obstructive pulmonary disease (COPD) patients stratified by different classifications: GOLD 2007, 2013, GesEPOC 2012 and BODEx index.Multicentre, observational, cross-sectional study. Patients were aged ≥40 years, with spirometrically confirmed COPD. Utility values derived from EQ-5D-3 L. Means, standard deviations (SD), medians interquartile ranges (IQR) computed based on the classifications. Differences in median between groups assessed...
Objective: Estimate the economic impact of severe asthma from Spanish social perspective through estimation associated annual direct and indirect costs. Methods: Observational, longitudinal, retrospective study carried out in 20 secondary settings (Pulmonology Allergy Services) among patients aged ≥18, diagnosed with according to European Respiratory Society/American Thoracic Society consensus who have not experienced an exacerbation previous 2 months. Asthma-related healthcare resource...
Background: Adherence to treatment is key achieve desired outcomes. In COPD, adherence generally suboptimal and impaired by complexity. Objective: To estimate the clinical economic impact of an improvement in due increased use once-daily single-inhaler triple therapy (SITT) patients with COPD. Patients Methods: A 7-state Markov model monthly cycles was developed. moderate-to-very severe for whom indicated, were included. Outcomes costs estimated compared two scenarios: current distribution...
Purpose: To evaluate the cost-effectiveness of once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) vs twice-daily budesonide/formoterol (BUD/FOR) in patients with symptomatic chronic obstructive pulmonary disease (COPD) at risk exacerbations, from Spanish National Healthcare System perspective. Patients and Methods: The validated GALAXY-COPD model was used to simulate progression predict healthcare costs, quality-adjusted life years (QALYs), incremental ratios (ICERs) over a...
Purpose: Guidelines recommend the use of triple therapy with an inhaled corticosteroid (ICS), a long-acting β 2 agonist (LABA) and muscarinic antagonist (LAMA) to reduce risk future exacerbations in symptomatic COPD patients history exacerbations. This study aimed estimate COPD-related healthcare resource costs, subsequent exacerbation rates, for initiating multiple-inhaler (MITT) early (≤30 days) versus late (31–180 following exacerbation, real-world clinical setting. Patients methods: was...
Objective: To describe resource use and costs of severe exacerbations in patients with asthma.Method: Secondary analysis an observational, longitudinal, retrospective study that estimated the economic impact asthma. The was carried out asthma units pulmonology allergy services 20 public hospitals (inclusion period: June to November 2016). included adult diagnosed according European Respiratory Society/American Thoracic Society consensus stable phase (no exacerbation during last 2 months), at...
Health utilities are widely used in health economics as a measurement of an individual's preference and show the value placed on different states over specific period. Thus, measure benefits interventions terms quality-adjusted life years. This study aimed to determine demographic clinical variables significantly associated with for chronic obstructive pulmonary disease (COPD) patients.This was multicenter, observational, cross-sectional conducted between October 2012 April 2013. Patients...
Multiple molecular mechanisms are involved in the pathogenesis of type 2 diabetes (T2D), with potentially different effects across ancestries. Recent large-scale efforts by Type Diabetes Global Genomics Initiative (T2DGGI) have broadly described genetic architecture T2D, data that can be subsequently used to pinpoint causal leading T2D an ancestry-aware manner. In this work, we sought explore gene expression and proteins on ancestries leveraging from latest T2DGGI multi-ancestry genome-wide...
Monogenic diabetes (MD) accounts for 0.4% of cases and is a paradigm precision medicine. However, high fraction variants in MD genes reported ClinVar have uncertain significance (VUS) or conflicting interpretations pathogenicity (CIP), making potential diagnosis challenge.We hypothesized that using large-scale rare variant association data type 2 (T2D) risk could inform the genes. We tested with T2D 1,157 VUS/CIP 52 established genes, largest rare-variant genome-wide study (51,256 T2D,...
The US overdose crisis is driving a surge in HIV diagnoses among persons who inject drugs (PWID). Innovative approaches are needed to address this increase cases. Although self-testing (HIVST) was hailed as potential "game-changer" upon initial approval by the Food and Drug Administration over decade ago, convenient testing modality has not reached its full impact epidemic. Nevertheless, lessons regarding for infectious diseases from COVID-19 pandemic present an opportunity HIVST uptake...
The Salford Lung Study in asthma (SLS asthma) is a 12-month, open-label randomised clinical trial comparing effectiveness of initiating once-daily inhaled combination fluticasone furoate/vilanterol (FF/VI) 184/22 mcg or 92/22 mcg, with continuing optimized usual care (UC) corticosteroids (ICS) alone, long-acting β2-agonist (ICS/LABA), asthmatic patients followed primary the UK. objective analysis to estimate economic impact these results when applied Spain.A 1-year cost-consequence model was...
The high prevalence of T2D among Latino individuals emphasizes the importance studying both environmental and genetic factors that influence disease in this population. However, is a recently admixed population with complex linkage disequilibrium patterns impose methodological challenges, especially when using genotype imputation to test association rare variation. recent release multi-ethnic NHLBI Trans-Omics for Precision Medicine (TOPMed) reference panel, comprising more than 100,000...