A5003834490- Growth Hormone and Insulin-like Growth Factors
- Hematopoietic Stem Cell Transplantation
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Reproductive Biology and Fertility
- Childhood Cancer Survivors' Quality of Life
- Lipid metabolism and disorders
- Immunotherapy and Immune Responses
- Pediatric Pain Management Techniques
- Tissue Engineering and Regenerative Medicine
- Acute Myeloid Leukemia Research
- Periodontal Regeneration and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Vector-borne infectious diseases
- Proteoglycans and glycosaminoglycans research
- Heat shock proteins research
- Platelet Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Complementary and Alternative Medicine Studies
- Rheumatoid Arthritis Research and Therapies
- Toxin Mechanisms and Immunotoxins
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- T-cell and Retrovirus Studies
University Hospital Regensburg
2013-2025
University of Regensburg
2025
Martin Luther University Halle-Wittenberg
2008-2015
University Hospital in Halle
2006-2007
Emory University
2002
University Children's Hospital Tübingen
1997-2001
Universitätskinderklinik
1998-1999
Temple Street Children's University Hospital
1998
University of Tübingen
1995
Ludwig-Maximilians-Universität München
1994
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2) has been shown to inhibit IGF-dependent cell proliferation in a number of vitro studies. However, no vivo model IGFBP-2 overexpression established so far. Therefore, we have generated transgenic mice, which expression mouse complementary DNA is controlled by the cytomegalovirus (CMV) promoter. In two independent strains, transgene was highest pancreas and stomach, followed skeletal muscle, heart, colon, spleen, adipose tissue,...
ABSTRACT: This study was conducted to investigate the relationships between results of computer‐assisted semen analysis (spermatozoal motility and sperm head morphometry) fertility boars. In addition, concentrations insulin‐like growth factor (IGF)‐I IGF‐II in seminal plasma were determined. The nonreturn rate (NRR) number live‐born piglets compatible with requirements artificial insemination for all boars included this study. Semen samples 12 (Pietrain; 3 ejaculates each) evaluated...
Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic and differentiation, but its function in postnatal life unclear. To address this point, we generated transgenic mice harboring fusion genes which a human IGF-II complementary DNA placed under the transcriptional control rat phosphoenolpyruvate carboxykinase promoter. Transgene-specific messenger RNA was detected liver, kidney, several parts gut. Serum levels were 2-3 times higher than those controls increased after...
ABSTRACT Introduction Veno‐occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life‐threatening condition characterised by of the small veins liver. Although typically associated with haematopoietic stem cell transplantation, VOD/SOS may also occur following intensive multimodal chemotherapy regimens. In children, symptoms are refractory thrombocytopaenia, weight gain, hepatomegaly, ascites and fluid retention, hyperbilirubinaemia sometimes right upper quadrant pain....
Abstract Life expectancy of patients with severe transfusion-dependent beta-thalassemia (TDT) remains below that the general population. Allogenic hematopoietic stem cell transplantation (HSCT) is standard curative treatment. Due to paucity matched donor (MD) availability, haploidentical HSCT (haplo-HSCT) a reasonable alternative. Twenty TDT (median age 10 years; range 2–23) received either sibling (MSD; n = 7) or haplo-HSCT ( 13) in single center (Regensburg, Germany) between 2016 and 2022,...
Pediatric patients with relapsed metastatic tumors have a poor prognosis and new treatment strategies are warranted. We present preliminary results of pilot study, evaluating the feasibility toxicity transplantation haploidentical T B cell depleted grafts high numbers NK cells. 6 neuroblastomas (n = 4), rhabdomyosarcoma 1) or Ewing's sarcoma after previous autologous received CD3/CD19 from mismatched family donors median number 16 × 106/kg stem cells, 167 Natural Killer cells only 5.4 104/kg...
Interleukin-2 (IL-2) transgenic Ewing sarcoma cells can induce tumor specific T and NK cell responses reduce growth in vivo vitro. Nevertheless, the efficiency of this stimulation is not high enough to inhibit completely. In addition recognition cognate antigen, optimal requires signals from so-called co-stimulatory molecules. Several members necrosis factor superfamily (TNFSF) have been identified as molecules that augment anti-tumor immune responses. OX40 (CD134) ligand (OX40L = CD252;...
The expression of the insulin-like growth factor binding protein-2 (IGFBP-2) was assayed in mononuclear cells originating from different organs immune system. All studied did express IGFBP-2, but level found to be dependent on cell type and origin cell. T showed a higher IGFBP-2 mRNA than B cells, CD34+ stem expressed at high level. Expression highest bone marrow thymus. Stimulation peripheral resulted marked increase also intracellular as analysed by fluorescence staining. This parallels...
Abstract Background Integrative medicine is used frequently alongside chemotherapy treatment in pediatric oncology, but little known about the influence on toxicity. This German, multi-center, open-label, randomized controlled trial assessed effects of complementary treatments toxicity related to intensive-phase children aged 1–18 with primary outcome sum score. Secondary outcomes were chemotherapy-related toxicity, overall and event-free survival after 5 years study patients. Methods...
Some of the early complications hematopoietic stem cell transplantation (HSCT) concerning small vessels can be summarized as transplant-associated systemic vasculopathies (TASV). One enzyme known to play a major role in inflammation, tissue remodeling, and repair processes well tumor metastasis is heparanase (HPSE). HPSE genetic variants have recently been associated with significant influence on risk developing certain TASV such sinusoidal obstruction syndrome. This study aimed validate two...
Hintergrund: Eine biphänotypische Leukämie stellt eine Seltenheit im Kindesalter dar und beschreibt Akute mit gleichzeitiger Expression von lymphatischen myeloischen Differenzierungmarkern. Je nach prozentualem Expressionsanteil wird die Therapie entweder ALL- bzw. AML-Protokollen durchgeführt.