A5101884651- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Neurological and metabolic disorders
- Neurological Disorders and Treatments
- Neonatal and fetal brain pathology
- Autoimmune Neurological Disorders and Treatments
- Infectious Diseases and Tuberculosis
- Peripheral Neuropathies and Disorders
- Intracranial Aneurysms: Treatment and Complications
- Mycobacterium research and diagnosis
- Complement system in diseases
- Cardiovascular Disease and Adiposity
- Infectious Encephalopathies and Encephalitis
- Grit, Self-Efficacy, and Motivation
- Cellular Mechanics and Interactions
- Cytomegalovirus and herpesvirus research
- Cervical and Thoracic Myelopathy
- Autophagy in Disease and Therapy
- Folate and B Vitamins Research
- Cerebral Venous Sinus Thrombosis
- Parasitic infections in humans and animals
- Ocular Diseases and Behçet’s Syndrome
Sun Yat-sen University
2013-2025
Third Affiliated Hospital of Sun Yat-sen University
2012-2025
Neurology, Inc
2013
Dongguan People’s Hospital
2005
Background and Purpose— The relationship between infarct dimensions neurological progression in patients with acute pontine infarctions remains unclear. This study aimed to investigate the morphometric predictive value of magnetic resonance imaging for early deterioration (END) infarction. Methods— We included all admitted our department having an ischemic stroke pons. ventrodorsal length multiplied by thickness was measured as parameters size. END defined incremental increase National...
Background: Thymosin alpha 1 (Tα1) had been used in kinds of inflammatory and immunodeficiency diseases as an immunomodulator. According to our clinic observation, patients with acute ischemic stroke (AIS) treated Tα1 prevent/cure post-stroke infection display favorable outcome. Whether exerts direct neuronal protection besides immunomodulation remains elusive. Aim: To explore the effect on after AIS unveil underlying mechanisms. Method: In vivo : 8-10 weeks old male Wild type (WT) mice were...
Non-alcoholic fatty liver disease (NAFLD) is closely correlated to visceral obesity, dyslipidaemia, insulin resistance and type 2 diabetes mellitus. We sought assess the association between a specific stroke subgroup, brainstem infarctions (BSIs) NAFLD. Furthermore, we evaluated whether NAFLD an independent risk factor in patients with BSIs.Non-alcoholic was assessed 306 radiologically confirmed BSIs via ultrasound. Differences without were compared. Data associated severity progression...
Background and Objectives C-reactive protein (CRP) is a biomarker of inflammation sensitive predictor stroke, high homocysteine (Hcy) also associated with stroke. However, the roles CRP Hcy in pathogenesis, progression prognosis branch atheromatous disease (BAD) lipohyalinotic degeneration (LD) are largely unknown. We sought to determine relation between them Chinese patients. Methods According lesion presences shown by diffusion-weighted imaging (DWI), we retrospectively recruited cohort...
Background and purpose Autoantibodies targeting the GluN1(NR1) subunit of anti‐ N ‐methyl‐D‐aspartate receptor (NMDAR) cause encephalitis. Although it has been shown that anti‐NMDAR encephalitis is associated with human leukocyte antigen (HLA) loci, susceptibility genes for disease outside HLA loci remain unidentified. In this study, we aimed to explore association non‐HLA genes. Methods Two Chinese cohorts from Han populations were recruited study. The North case–control set consisted 98...
Female, 17 FINAL DIAGNOSIS: Wernicke's encephalopathy Symptoms: Blurred vision • dizziness nystygmus tachycardia- Clinical Procedure: - Specialty: Neurology.Mistake in diagnosis.Wernicke's (WE) is an acute and life-threatening illness which not only seen alcoholics, but also persons with poor nutrition lacking thiamine (vitamin B1).Here, we presented a case of WE patient who received parenteral without complement thiamine. Besides neuropsychiatric problems, she manifested prominent...
<b><i>Aim:</i></b> To investigate the association of hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) with acute diffusion-weighted imaging lesion volumes (DIV) and early neurologic deterioration (END) in brainstem infarctions (BSIs). <b><i>Methods:</i></b> 152 patients BSIs were included this study. The relationship between HbA<sub>1c</sub> DIV quartiles was examined. Data considered potentially associated END...
Intracranial tuberculoma and neurocysticercosis (NCC) are the most frequent granulomatous infections in central nervous system. Here we report a 41-year-old man with disseminated intracranial mimicking NCC. The patient complained of relapsing vertigo vomiting consistent Bruns syndrome. Serum antibodies against cysticercosis were positive. Magnetic resonance imaging (MRI) brain showed multiple ring-enhanced lesions. An initial diagnosis NCC was made based on clinical signs MRI. However,...
Background and purpose This study aimed to evaluate the relationship between serum complement anti‐ N ‐methyl‐ d ‐aspartate receptor ( NMDAR ) encephalitis. Methods Serum (C3, C4 CH 50), immunoglobulins (IgG, IgM IgA) C‐reactive protein CRP were evaluated in 40 patients with encephalitis controls. Follow‐up evaluations of 11 conducted 6 months after admission. Modified Rankin Scale mRS scores clinical cerebrospinal fluid parameters Results levels significantly higher than controls P =...
The underlying causes of minor stroke are difficult to assess. Here, we evaluate the reliability Chinese Ischemic Stroke Subclassification (CISS) system in patients with stroke, and compare it Trial Org 10172 Acute Treatment (TOAST) system.A total 320 were retrospectively registered categorized into different subgroups CISS TOAST by two neurologists. Inter- intra-rater agreement systems assessed kappa statistics.The percentage undetermined etiology (UE) cases was 77.3 % less than that...
Abstract Objectives The association of branch atherosclerotic disease ( BAD ) and diabetes mellitus DM in the territory posterior circulation is rarely discussed. Intracranial was divided into two different types: paramedian pontine arteries PPA PPD lenticulostriate LSA disease. goal study to evaluate clinical characteristics its with hemoglobinA1c (HbA1c) China. Materials Methods Radiologically confirmed defined as an isolated unilateral infarction extending ventral surface pons. Small deep...
To the Editor: Ischemic stroke remains a major cause of death and disability worldwide contributes to rising costs health care. Thrombolytic therapy with tissue plasminogen activator (tPA, alteplase) is beneficial for treatment acute ischemic stroke. However, only 40% 50% patients show significant improvement after treatment. In addition, use alteplase restricted because symptomatic intracranial hemorrhage (sICH) occurs in 1.7% 6.4% treated patients.[1] 25-hydroxyvitamin D (25(OH)D), which...
：Objective To study therole of IL-17 in the pathogenesy and differential diagnosis 3 types CNSinfections (tubercular meningitis [TBM], cryptococcal [CM], viralmeningoencephalitis [VM]). Methods One hundred twelve patients with CNSinfections,admitted to out hospital from February 2008 December 2009, were chosen anddivided into TBM group, CM group VM group;another 36 without CNS infectionseither autoimmune disease at same period as control group. ELISA wasemployed determine levels IL-17,IL-12,...
Objective To create a simple differential diagnostic rule for tuberculous meningitis and cryptococcal in adults on the basis of basic clinical laboratory features. Methods We compared features 219 admitted to our hospital during period 2000-2008; these patients satisfied criteria (n=100) (n=119). Multivariate logistic regression analysis was employed find risk factors those could independently predict meningitis,so that be created. Results Six were found, including gender, mind disorder,...