A5101407606- Liver Disease Diagnosis and Treatment
- High Altitude and Hypoxia
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Vascular Malformations and Hemangiomas
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- HER2/EGFR in Cancer Research
- Traditional Chinese Medicine Studies
- Hemodynamic Monitoring and Therapy
- Healthcare and Venom Research
- Respiratory and Cough-Related Research
- Neuroscience and Neuropharmacology Research
- Cardiovascular and Diving-Related Complications
- Heart Rate Variability and Autonomic Control
- Metabolomics and Mass Spectrometry Studies
Northern Jiangsu People's Hospital
2024
China Three Gorges University
2011-2024
Shanghai Jiao Tong University
2009-2024
Renji Hospital
2024
Xijing Hospital
2012-2021
National Clinical Research Center for Digestive Diseases
2021
Yichang Central People's Hospital
2007-2020
Changzhi Medical College
2013-2020
University College London Hospitals NHS Foundation Trust
2020
University College London
2020
The present study was undertaken to investigate the regulation of P12(CDK2AP1) by miRNAs. A conserved target site for miR-21 within CDK2AP1-3'-UTR at nt 349-370 predicted bioinformatics software and an inverse correlation CDK2AP1 protein observed. Highly specific amplification quantification achieved using real-time RT-PCR. Transfection HaCaT cells with pre-miR-21 significantly suppressed a luciferase reporter including CDK2AP1-3'-UTR, whereas transfection Tca8113 anti-miR-21 increased...
Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor rare throughout most of the world but common in Southeast Asia, especially Southern China. The phosphorylation eukaryotic translation initiation factor 4E (eIF4E) by MAP kinase-interacting kinases (Mnk) on Ser-209 promotes cellular proliferation, survival, transformation metastasis. However, whether alterations expression p-eIF4E p-Mnk1 protein are associated with clinicopathologic/prognostic implication for NPC has not been...
CD97 is a member of the epidermal growth factor-seven transmembrane family. It affects tumor aggressiveness by binding its cellular ligand CD55 and exhibits adhesive properties. Previous studies have shown that are involved in dedifferentiation, migration, invasiveness metastasis tumors. However, little known regarding roles pancreatic cancer. In this study, immunohistochemistry was used to analyze protein expression samples obtained from 37 cancer patients. were absent or only weakly...
Long non-coding RNA (lncRNA) has been shown to be a vital regulator of cancer progression, including hepatocellular carcinoma (HCC). However, the role DEAD/H box protein 11 antisense 1 (DDX11-AS1) in HCC remains further studied. The expression levels DDX11-AS1, miR-195-5p and metastasis-associated colon cancer-1 (MACC1) were determined by quantitative real-time PCR (qRT-PCR). Cell counting kit-8 (CCK-8), transwell apoptosis determination assays used evaluate cell proliferation, migration,...
As one of the most common and aggressive cancer types, hepatocellular carcinoma (HCC) leads to a large number fatalities every year. However, pathogenesis HCC remains largely unknown. In present study, it was identified that FEZF1‑AS1 significantly upregulated in cell lines tissues, as determined by reverse transcription‑quantitative polymerase chain reaction. Additionally, observed higher expression patients with indicated poorer prognosis. Furthermore, knockdown markedly inhibited...
Gliomas are the leading cause of death among adults with primary brain malignancies. Treatment for malignant gliomas remains limited, and targeted therapies have been incompletely explored. In this study, we found that protein expression presenilin 2 (PS2) was significantly increased in glioma tissues, at least partially because promoter demethylation. We further evaluated biological functions PS2 U251 cell proliferation, migration, invasion, tumor growth vivo by specific inhibition using...
Cancer is a common disease threatening human health, chemotherapy widely used in clinical treatment of cancer, but chemotherapy-induced peripheral neuropathy (CIPN) has relevant impact on life quality cancer patients. Administration gastrodin can relieve chronic pain to patients with CIPN and attenuated the inflammatory response by reducing expression tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6). However, its exact molecular mechanisms remain unclear. In this study, we established an...
(1) Background: polycystic ovarian syndrome (PCOS) is a heterogeneous with constellation of cardiometabolic risk factors. We aimed to investigate if the association body fat mass (BFM) and skeletal muscle (SMM) differed in PCOS subtypes. (2) Methods: 401 participants (245 156 controls) were assessed for anthropometric measurements, glucose–lipid profiles, reproductive hormones composition propensity score-matched (PSM) analysis. The score (z score, calculated based on levels obesity...
Kaixinjieyu (KJ), derived from Kaixin and Sini powder, is an effective Chinese herbal medicine preparation used in the treatment of vascular depression (VD). We hypothesize that broad antidepressant effect KJ results improved neurovascular unit (NVU) function via neurogenesis, permeability blood-brain barrier (BBB) balance fibrinolytic system.A VD model rat was established by chronic unpredictable mild stress separation after ligation bilateral common carotid arteries. The rats were treated...
Ovarian cancer is a common malignant tumor of the gynecological oncology worldwide, with high incidence and mortality rate poor prognosis. Searching for new diagnostic molecular biomarkers ovarian extremely significant.Here, we analyzed expression rates eIF4E cyclin D1 proteins in 123 cases tissue samples 38 paracancerous studied connection between by immunohistochemistry statistically correlated clinicopathological features cancer.The results showed that tissues were significantly higher...
The effects of methamphetamine were studied on cardiovascular function in conscious squirrel monkeys. Methamphetamine (0.1-3.0 mg/kg, IV) produced a dose-dependent increase blood pressure. Its heart rate more complex, with lower doses (0.1-0.3 mg/kg) producing increases and higher (1.0-3.0 decreases. To determine the pharmacological mechanisms involved methamphetamine's effects, number drugs tested as pretreatments to an injection 0.2 mg/kg methamphetamine. This dose maximal increase. alpha...
Tetramethylpyrazine (TMPZ) is one of the active compounds extracted from traditional Chinese herb Chuanxiong.Several studies have shown its anti-cancer properties.However, functions in lung cancer and underlying cellular mechanisms are relatively unknown.Our present study aimed to investigate effects TMPZ on A549 95D cells.The MTT assay showed that decreased cell viability a dose-and time-dependent manner.The results colony formation indicated strongly suppressed ability cells.Flow...
VX680 is an Aurora A inhibitor. It has been reported to inhibit the growth of HepG2 cell line in several studies. However, whether it enhances chemosensitivity cisplatin remains unclear. In this study, synergistic effect and on proliferation cells was determined by MTT assay. The changes apoptosis were detected flow cytometry. A, Bcl-2 p53 protein levels analyzed western blotting. This study demonstrated that VX680, a combination two dose- time-dependent manner. observed with combined...
Evaluation of the degree liver fibrosis is an important basis for clinical diagnosis and treatment patients with hepatocellular carcinoma (HCC). It meaningful to make a preoperative evaluation non-invasive methods. In current study, 12 commonly used serological indicators from 161 HCC different were collected retrospectively, 8 (ALB, PA, TBil, INR, AST, GGT, ALP, PT) ultimately in matter-element analysis create formula. The relationship between those results histological sub-classification...
Pancreatic cancer is one of the deadliest cancers with very poor prognosis, and five-year survival rate patients less than 5% after diagnosis. Kallikrein-related peptidases (KLKs) belong to a serine protease family 15 members that play important roles in cellular physiological behavior diseases. The high expression level KLK7 pancreatic tissues considered be marker for prognosis this disease. In work, we set out investigate whether could target treatment cancer. Short hairpin RNAs (shRNAs)...
Objective The aim of this study was to establish a clinical scoring formula liver injury (SFLI) using the matter element analysis method, in order provide necessary information for preoperative assessment and treatment cirrhosis practice. Materials methods We collected 12 serum biochemical markers (ALB, PA, TBil, SCr, INR, ALT, AST, γ-GT, ALP, PT, APTT, TT) from patients with cirrhosis, statistically analyzed relationship between extent injury, obtained method. Results In our formula,...