A5091436677- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Transplantation Outcomes and Treatments
- Vascular Procedures and Complications
- Renal and Vascular Pathologies
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Data-Driven Disease Surveillance
- Infectious Aortic and Vascular Conditions
- Central Venous Catheters and Hemodialysis
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Electrospun Nanofibers in Biomedical Applications
- Viral Infections and Vectors
- Neurological and metabolic disorders
- Dutch Social and Cultural Studies
- Anesthesia and Neurotoxicity Research
- Aortic Disease and Treatment Approaches
- Dialysis and Renal Disease Management
- Peripheral Artery Disease Management
- Tissue Engineering and Regenerative Medicine
National Institute for Public Health and the Environment
2000-2024
Dutch Expert Centre for Screening
2019-2020
Health Forecasting
2020
Radboud University Nijmegen
2010-2019
Radboud University Medical Center
2009-2019
University Medical Center
2010-2018
Leiden University Medical Center
2013
Nanyang Technological University
2013
Center for Vascular Biology Research
2011
Lund University
2009
Case and single center reports have documented the feasibility suggested effectiveness of endovascular aneurysm repair (EVAR) ruptured abdominal aortic aneurysms (RAAAs), but role value such treatment remain controversial.To clarify these we examined a collected experience with use EVAR for RAAA from 49 centers.Data were obtained by questionnaires centers, updated 13 centers committed to whenever possible included details information on 1037 patients treated 763 open (OR).Overall 30-day...
The immune competent abdominal adipose tissue, either stored viscerally [visceral tissue (VAT)] or sc [sc (SAT)], has been identified as a source of IL-1β and IL-18. To become active, the proforms these cytokines require processing by caspase-1, which itself is mediated inflammasome. In this descriptive study, we investigate expression inflammasome components caspase-1 in human fat determine whether activity contributes to enhanced inflammatory status VAT. Paired SAT VAT biopsies from 10...
Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced cell formation mesenteric lymph nodes. Here we characterized the regulation of Angptl4 expression macrophages examined impact on atherosclerosis development.Macrophage activation elicited by pathogen-recognition receptor agonists decreased expression, whereas lipid loading...
Neuromuscular function was evaluated in long-term type I diabetic patients who retained a functioning pancreas graft. A group of 34 examined at 1 year and another 11 2 years after transplantation. In this report the clinical electrophysiological course motor features poly-neuropathy are described. Before transplantation, evidence polyneuropathy present all patients. The mean nerve conduction velocities (NCV) were below normal amplitude evoked muscle action potentials (MAP) low range....
To determine to what extent current cold ischemia times (CITs) affect the results of renal transplantation in Netherlands.Retrospective survey Dutch Organ Transplant Registry concerning transplants from deceased donors between 1990 and 2007.A total 6322 recipients were identified, whom 5306 received a kidney heartbeating (HBD) 1016 after cardiac death (DCD). Mean CIT was 24.0 ± 7.9 h HBD 21.6 6.7 DCD. The percentage delayed graft function (DGF) 12.3 50.4, respectively (p < 0.001). Primary...
A persistent clinical demand exists for a suitable arterial prosthesis. In this study, vascular conduit mimicking the native 3-layered artery, and constructed from extracellular matrix proteins type I collagen elastin, was evaluated its performance as blood vessel equivalent.A tubular graft (elastin-collagen-collagen) prepared using highly purified fibrils elastin fibers, resembling architecture. The crosslinked heparinised (37 ± 4 μg heparin/mg graft), porcine bilateral iliac artery model....
Abstract Background The mortality rate associated with ruptured abdominal aortic aneurysm (AAA) remains high. objective of this study was to assess the feasibility population screening for AAA. Methods In an area a mixed rural and industrialized 60 000 inhabitants, all 23 general practitioners (GPs) participated. GPs selected from their patient lists men aged 60–80 years. Men whose condition suitable surgery were invited by single postal letter. All responding had ultrasonography in or close...
The purpose of this study was to investigate whether a protocol for permissive hypotension feasible patients admitted with ruptured abdominal aortic aneurysm (RAAA). It aimed limit prehospital intravenous fluid administration 500 mL and maintain systolic blood pressure at range 50 100 mm Hg following admission, using nitrates when indicated. diagnosis RAAA confirmed sonography, all uncontrolled hypovolemic shock immediately underwent open repair (OAR). In other cases, computed tomographic...
Summary In cadaveric organ transplantation there is a risk of transfer infectious agents from donor to recipient. The consequences can be fatal for immuosuppressed recipients. This illustrated by case history in which an infection with the fungus Monosporium apiospermum was transferred two kidney recipients, whom one died and other surviced loss graft. These events led review literature determine methods demonstrating possible contamination organs. Analysis potential donors, taken relatives...
Abstract —In this article, we describe the results of a comparative study for detection Chlamydia pneumoniae in abdominal aortic aneurysm specimens 19 patients through use immunocytochemistry (ICC), situ hybridization (ISH), and polymerase chain reaction (PCR), along with cytomegalovirus (CMV) herpes simplex virus (HSV) by ICC PCR. C –specific membrane protein was detected all (100%; 95% confidence interval [CI] 82% to 100%) 15 (79%; CI 54% 94%) monoclonal antibodies RR-402 TT-401,...
To determine the relationship between ankle/brachial indices (ABIs) and morbidity mortality in patients with peripheral arterial disease (PAD), a historical cohort study was performed. A total of 154 who had undergone noninvasive assessment lower extremities 1989 1990 were selected for this purpose. Selection criteria age > 40 years at time investigation, resting ABI < 0.90 availability an after exercise or occlusion. Mortality vascular events recorded average follow-up period 6 years. event...
Poor early graft function (EGF) after living donor kidney transplantation (LDKT) has been found to decrease rejection-free survival rates. However, its influence on long-term remains inconclusive.Data were collected 472 adult LDKTs performed between July 1996 and February 2010. EGF was defined as the occurrence of delayed or slow function. Slow serum creatinine above 3.0 mg/dL at postoperative day 5 without dialysis.The incidence 9.3 4.4%, respectively. Recipient overweight, pretransplant...
Following a one-month prospective study of antimicrobial drug use in surgical departments, new guidelines were implemented. The review was repeated after two years. In both periods, one third patients prescribed drugs. Prophylactic antibiotic consumption decreased from 0.75 to 0.53 defined daily doses/operation. Compliance with improved 32% 79%. Duration prophylaxis > 24 h 21% 8%. Single dose increased 34% 80%. Quality the prophylactic courses improved, as evaluated by experts using...
Most postoperative patients lose net protein mass, which reflects loss of muscle tissue and organ function. Perioperative parenteral nutrition may reduce the protein, but in general, with conventional lipid emulsions a waste still remains.We compared effects on nitrogen balance an emulsion containing structured triglycerides, new type synthesized physical mixture medium- long-chain triglycerides as part feeding moderately catabolic patients. The first 5 days after placement aortic prosthesis...