A5103036678- Magnesium in Health and Disease
- IL-33, ST2, and ILC Pathways
- Multiple Myeloma Research and Treatments
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Cell Adhesion Molecules Research
- Orthopaedic implants and arthroplasty
- FOXO transcription factor regulation
- Medicinal Plants and Bioactive Compounds
- Immune Response and Inflammation
- Aluminum toxicity and tolerance in plants and animals
- Reproductive tract infections research
- Economic Sanctions and International Relations
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Ion Channels and Receptors
- Kruppel-like factors research
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
Nanjing Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Nanjing University
2023-2024
Guangzhou Medical University
2022-2024
Hangzhou Medical College
2022-2023
Zhejiang Provincial People's Hospital
2022-2023
Soochow University
2022
Beijing Fengtai Hospital
2022
Beijing University of Chinese Medicine
2022
The University of Queensland
2019-2020
Virus-induced apoptosis has been well characterized in vitro, but the role of viral pathogenesis is not understood. The suicide a cell response to infection postulated be an important host defense for organism, leading reduction its total burden. However, virus-induced death nonregenerating cells central nervous system may detrimental host. Therefore, investigate fatal encephalitis, we constructed recombinant alphavirus chimera that expresses antiapoptotic gene, bcl-2, virally infected...
The present study aimed to evaluate anti-rheumatoid arthritis (RA) effect of Lonicerin (LON), a safe compound with anti-inflammatory and immunomodulatory properties. Nevertheless, the exact role LON in RA remains elusive. In this test, anti-RA was evaluated collagen-induced (CIA) mouse model. Relevant parameters were measured during experiment; ankle tissue serum collected at end experiment for radiology, histopathology, inflammation analysis. ELISA, qRT-PCR, immunofluorescence, western blot...
Abstract Periprosthetic osteolysis (PPO) caused by wear particles is one of the leading causes implant failure after arthroplasty. Macrophage polarization imbalance and subsequent osteogenic inhibition play a crucial role in PPO. Calycosin (CA) compound with anti‐inflammatory osteoprotective properties. This study aimed to evaluate effects CA on titanium (Ti) particle‐induced osteolysis, Ti macrophage deficits, explore associated signalling pathways particle‐stimulated calvarial mouse model...
Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of malignant plasma cells. Though durable remissions are possible, MM considered incurable, with relapse occurring in almost all patients. There has been limited data reported on lipid metabolism changes cells during progression. Here, we evaluated feasibility concurrent lipidomics and proteomics analyses from patient cells, report these number samples, demonstrating method, establishing hypotheses to...
AbstractPurpose: Cellular senescence and mitochondrial fragmentation are thought to be crucial components of the cigarette smoke(CS)-induced responses that contribute chronic obstructive pulmonary disease (COPD) development as a result accelerated premature aging lung. Although there have been few reports on role sirtuin 1(SIRT1) in homeostasis, inflammation, whether SIRT1/FOXO3/PINK1 signaling mediated mitophagy ameliorates cellular COPD is still unclear. This study aimed ascertain SIRT1...
ABSTRACT Interleukin-1β (IL-1β) concentrations are frequently elevated in central nervous system (CNS) viral infections, but the pathophysiologic significance of such elevations is not known. To examine role IL-1β CNS pathogenesis, we compared natural histories IL-1β-deficient and wild-type 129 SV(ev) mice infected with a neurovirulent strain, neuroadapted Sindbis virus (NSV). We found that incidence severe paralysis death was markedly decreased NSV-infected −/− to (4 versus 88%, P <...
Because cigarette smoke can induce COPD/emphysema through accelerating senescence with or without an incomplete repair system. However, the pathogenesis of COPD following lung induced by CS is not fully understood. Airspace enlargement and airway epithelial cell are common finding during development. We investigated tress response to demonstrated that a stress-responsive transcription factor, FOXO3, was regulated deacetylase. SIRT1 inhibited FOXO3 acetylation degradation, leading...
Febuxostat is a novel inhibitor of xanthine oxidase that suppresses cell adhesion molecules-mediated (CAMs) inflammation by activating KLF6. In this study, we explored the therapeutic function and potential mechanisms febuxostat against allergic rhinitis (AR).We investigated role through in vitro vivo animal experiments. Human nasal epithelial cells (hNECs) were cultured with histamine as an model. To establish AR model, rats exposed to ovalbumin. Rats randomly grouped into control, 7.5...
Abstract Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of malignant plasma cells. Though durable remissions are possible, MM considered incurable, with relapse occurring in almost all patients. There has been limited data reported on lipid metabolism changes cells during progression. Here, we evaluated feasibility concurrent lipidomics and proteomics analyses from patient cells, report these number samples, demonstrating method,...
Group 2 innate lymphoid cells (ILC2) play a critical role in type immunity. Although their classical activators are known to be host epithelial-derived alarmin cytokines released from tissue damage at barrier sites during microbial infections and allergen exposures, it remains elusive whether ILC2 can directly activated by ligands. Here we examined number of ligands identified lipopolysaccharides (LPS) multiple species Gram-negative bacteria potently stimulated the cultured human proliferate...