A5019026451- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Bioactive Natural Diterpenoids Research
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Signaling Pathways in Disease
- Heart rate and cardiovascular health
- Natural Compounds in Disease Treatment
- Gout, Hyperuricemia, Uric Acid
- Peptidase Inhibition and Analysis
- Sesquiterpenes and Asteraceae Studies
- Cardiac Ischemia and Reperfusion
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Traditional Chinese Medicine Analysis
- E-Learning and Knowledge Management
- Protease and Inhibitor Mechanisms
- Calpain Protease Function and Regulation
- Public Health in Brazil
- Lipid metabolism and biosynthesis
- Phytochemistry and Bioactive Compounds
- Neuroscience of respiration and sleep
- Cardiac Fibrosis and Remodeling
Universidad Complutense de Madrid
2013-2025
Universidad de Alcalá
2016-2018
Instituto Ramón y Cajal de Investigación Sanitaria
2017
Universidad Francisco de Vitoria
2015-2016
Universidad de La Laguna
2011
Abstract Epidemiological studies link long term exposure to xenoestrogen Bisphenol-A adverse cardiovascular effects. Our previous results show that BPA induces hypertension by a mechanism involving CamKII activation and increased redox stress caused eNOS uncoupling. Recently, sustained has been recognized as central mediator of programmed cell death in diseases, including necroptosis. However, the role necroptosis cardiac response had not yet explored. Mice exposed for 16 weeks showed...
Adipose tissue dysfunction is an important determinant of obesity-associated, lipid-induced metabolic complications. Ceramides are well-known mediators insulin resistance in peripheral organs such as muscle. DEGS1 the desaturase catalyzing last step main ceramide biosynthetic pathway. Functional suppression activity results substantial changes species likely to affect fundamental biological functions oxidative stress, cell survival, and proliferation. Here, we show that degs1 expression...
Inhibition of extracellular matrix (ECM) degradation may represent a mechanism for cardiac protection against ischemia.Extracellular metalloproteinase inducer (EMMPRIN) is highly expressed in response to acute myocardial infarction (AMI), and induces activation several metalloproteinases (MMPs), including gelatinases MMP-2 MMP-9.We targeted EMMPRIN with paramagnetic/fluorescent micellar nanoparticles conjugated the binding peptide AP-9 (NAP9), or an scrambled as negative control (NAPSC).We...
Crataegus azarolus L. (Rosaceae), commonly known as Mediterranean hawthorn, has long been valued in Traditional Medicine for treating cardiovascular and inflammation-related diseases, including diabetes, cancer, rheumatism. Pharmacological benefits of are notably linked to its anti-inflammatory properties. Fupenzic acid, a pentacyclic triterpene isolated from leaves, holds significant pharmacological potential that remains elusive. This study investigates the unexplored capacity fupenzic...
Several labdane diterpenes exert anti-inflammatory and cytoprotective actions; therefore, we have investigated whether these molecules protect cardiomyocytes in an anoxia/reperfusion (A/R) model, establishing the molecular mechanisms involved process. The cardioprotective activity of three (T1, T2 T3) was studied H9c2 cell line isolated rat cardiomyocyte subjected to A/R injury. In both cases, treatment with T1 protected from A/R-induced apoptosis, as deduced by a decrease percentage...
ILK (integrin-linked kinase) plays a key role in controlling vasomotor tone and is decreased atherosclerosis. The objective of this study to test whether nitric oxide (NO) regulates vascular remodeling.We found striking correlation between increased levels inducible human atherosclerosis mouse model remodeling (carotid artery ligation) comparing with iNOS (inducible NO synthase) knockout mice. induction produced the same result aortic endothelial cells, these effects were mimicked by an...
Dehydroisohispanolone (DIH), is a labdane diterpene that has exhibited anti-inflammatory activity via inhibition of NF-κB activation, although its potential effects on inflammasome activation remain unexplored. This study aims to elucidate whether DIH modulates NLR family pyrin domain-containing protein 3 (NLRP3) in macrophages. Our findings show inhibited NLRP3 triggered by Nigericin (Nig), adenosine triphosphate (ATP) and monosodium urate (MSU) crystals, indicating broad inhibitory...
A series of nine derivatives (2⁻10) were prepared from the diterpene solidagenone (1) and their structures elucidated by means spectroscopic studies. Their ability to inhibit inflammatory responses elicited in peritoneal macrophages TLR ligands was investigated. Compounds 5 6 showed significant anti-inflammatory effects, as they inhibited protein expression nitric oxide synthase (NOS-2), cyclooxygenase-2 (COX-2), cytokine production (TNF-α, IL-6, IL-12) induced ligand TLR4,...
Acute heart failure patients could benefit from rate reduction, as myocardial consumption and oxidative stress are related to tachycardia. Ivabradine have a clinical role attenuating catecholamine-induced The aim of this study was evaluate hemodynamic effects ivabradine in swine model acute failure.
Inhibition of Extracellular Matrix degradation by nitric oxide (NO) induces cardiac protection against coronary ischemia/reperfusion (IR). Glycosylation Metalloproteinase Inducer (EMMPRIN) stimulates enzymatic activation matrix metalloproteinases (MMPs) in the heart, although mechanisms leading to EMMPRIN glycosylation are poorly understood. We sought determine if NO may induce preventing a mouse model IR. Here we found that Caveolin-3 binds low glycosylated (LG-EMMPRIN) cells and hearts...
A set of new dihydroquinoline embelin derivatives was obtained from the reaction natural benzoquinone (1) with anilines and aromatic aldehydes in presence AgOTf. The synthesis these compounds involves formation a Knoevenagel adduct, followed by nucleophilic addition aniline subsequent electrocyclic ring closure. scope regarding determined. Quinoline were also corresponding dihydroquinolines under oxidation DDQ. cardioprotective activity synthesized screened using doxorubicin-induced...
Purpose: Anti‐inflammatory and antioxidant evaluation of idebenone (IDB) in ARPE‐19 cell line subsequent encapsulation PLGA (polylactic‐co‐glycolic‐acid)/vitamin E microspheres (MS), together with neurotrophic factors, to confer additional neuroprotective activity technological advantages. Methods: ARPE‐19, a human RPE line, were incubated for 24 IDB (0.5‐150 μM) determine viability by MTT assay. For anti‐inflammatory evaluation, cells pre‐treated (10 3 h then, stimulated LPS μg/mL;24 h)....
The NLRP3 inflammasome plays a critical role in inflammation-mediated human diseases and represents promising drug target for novel anti-inflammatory therapies. Hispanolone is labdane diterpenoid isolated from the aerial parts of Ballota species. This some derivatives have demonstrated effects classical inflammatory pathways. In present study, series dehydrohispanolone (1–19) was synthesized, their activities toward activation were evaluated. structures analogues produced elucidated by NMR...
Abstract The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. Therefore, to explore novel strategies cardioprotective effects, series of new labdane conjugates were prepared ( 6a – 6c and 8a 8d ) from the natural diterpene labdanodiol 1 ). These hybrid compounds contain anti‐inflammatory privileged structures such as naphthalimide, naphthoquinone, furanonaphthoquinone. Biological activity these against...
The 2021-updated guidelines of the Spanish Society Neonatology Guidelines have moved zone parental discretion to 23 + 0-23 6 weeks. objective this study was describe changes in perinatal management at gestational age along last decade and determine if a more active has contributed improved outcomes.Retrospective analysis prospectively collected data from 23-week infants included SEN 1500 neonatal network during period 2010-2019. main outcomes were survival discharge without major morbidity...