A5101410550- Hormonal Regulation and Hypertension
- Bone Tissue Engineering Materials
- Ion Transport and Channel Regulation
- Liver Disease Diagnosis and Treatment
- Natural Antidiabetic Agents Studies
- Magnesium Alloys: Properties and Applications
- Vaccine Coverage and Hesitancy
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- Aluminum Alloys Composites Properties
- COVID-19 Impact on Reproduction
- Heart Failure Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Child Nutrition and Water Access
- Sepsis Diagnosis and Treatment
- Estrogen and related hormone effects
- Global Maternal and Child Health
- Electrolyte and hormonal disorders
- Infection Control in Healthcare
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Education and Character Development
- Education and Communication Studies
- Phytochemistry and Biological Activities
- Burn Injury Management and Outcomes
University of Mississippi Medical Center
2021-2024
G.V. (Sonny) Montgomery VA Medical Center
2021-2024
Nanyang Technological University
2024
Singapore Eye Research Institute
2024
Singapore General Hospital
2024
Dhaka University of Engineering & Technology
2024
University of Mississippi
2021-2023
University of Virginia Health System
2023
Neurological Surgery
2023
Debre Tabor University
2023
Abstract The mineralocorticoid receptor (MR) is a transcription factor for genes mediating diverse, cell-specific functions, including trophic effects as well promoting fluid/electrolyte homeostasis. It was reported that in intercalated cells, phosphorylation of the MR at serine 843 (S843) by Unc-51–like kinase (ULK1) inhibits activation and ULK1 mechanistic target rapamycin (mTOR) inactivates ULK1, thereby prevents inactivation. We extended these findings with studies M1 mouse cortical...
Magnesium (Mg) and its alloys are prospective biodegradable metallic implant materials. This research focuses on addressing the high corrosion rate of WE54 Mg alloys, limiting their biomedical applications as implants. The study proposes a novel approach by developing hybrid coatings these materials, combining organic PLA (poly-lactic acid) inorganic HA (hydroxyapatite) substances. exhibit significantly improved protection biocompatibility, reducing degradation in vitro rates body fluid...
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face setbacks, emphasizing the need for preclinical models that faithfully mimic human and its comorbidities. The progression aggravation diet (LIDPAD), a diet-induced murine model, extensively characterized under thermoneutral conditions refined diets is introduced to ensure reproducibility minimize species differences. LIDPAD recapitulates...
Aims GJB4 encodes a transmembrane connexin protein (Cx30.3) that is component of gap junctions. This study investigated whether plays an important role in human heart disease and function. Methods results We examined patient her older brother who both presented with complicated severe hypertrophic cardiomyopathy (HCM) whose parents are healthy married cousins. The gene exome analysis showed 340 single nucleotide polymorphisms (SNPs) caused amino acid changes for which the was homozygous were...
Background: Oxidative stress is strongly linked in the development of numerous chronic and degenerative disorders. Medicinal plants with antioxidant anticholinesterase activities exert a key role for management oxidative related disorders mainly Alzheimer's disease (AD). Therefore purpose this study was to assess potentiality inhibitory activity crude methanolic extract (CME), petroleum ether fraction (PEF), chloroform (CLF), ethyl acetate (EAF) aqueous (AQF) Uvaria littoralis (U....
Purpose To determine the degree of pain and discomfort associated with transrectal sonography (TRS)-guided biopsy prostate to analyze complications this procedure. Methods Three hundred men referred as part an investigation exclude cancer were studied. The reasons for referral suspected due increased serum prostate-specific antigen level (>4 ng/ml), finding a palpable nodule or greater firmness one prostatic lobe than other on digital rectal examination, suspicious area neoplasm TRS biopsy....
Background Myosin phosphatase targeting subunit 2 (MYPT2) is an important of cardiac MLC (myosin light chain) phosphatase, which plays a crucial role in regulating the phosphorylation to phospho‐MLC (p‐MLC). A recent study demonstrated mineralocorticoid receptor‐related hypertension associated with RhoA/Rho‐associated kinase/MYPT1 signaling upregulation smooth muscle cells. Our purpose investigate effect MYPT2 on function and fibrosis hypertension. Methods Results HL‐1 murine cardiomyocytes...
Background and Purpose We investigated the inhibitory effect associated molecular mechanisms of tolvaptan on angiotensin II (AngII)‐induced aldosterone production in vitro vivo. Experimental Approach In vitro, H295R human adrenocarcinoma cells were incubated with 1 μmol·L −1 arginine vasopressin (AVP) or dDAVP, (0.1, 1, 3 ) presence absence 100 nmol·L AngII. vivo, Sprague–Dawley rats treated 0.05% diet for 6 days 200 pmol·min Key Results Tolvaptan suppressed AngII‐induced a dose‐dependent...
The aim of the current study is to investigate effect combination glibenclamide; an antidiabetic drug and simvastatin; a HMG-CoA reductase inhibitor on long-term (four weeks) alloxan-induced diabetes rats (ADRs). Methods: Alloxan (120 mg/kg body weight, BW) was injected intra-peritonially (i.p.) in rats. At first alloxan induced diabetic were treated with single dose glibenclamide (1.2 mg/70kg simvastatin (10 for two weeks. Then fixed combinations (0.6 (5 along those drugs four Results: it...
Objective: The kidney plays a central role in regulating the salt sensitivity of blood pressure (BP) by governing sodium excretion and reabsorption via renal transporters. We hypothesized that sodium-glucose cotransporter 2 (SGLT2) inhibition angiotensin II type 1 receptor (AT R) blockade can synergistically reduce beneficially effects on these transporters, leading to lower BP ameliorating cardiac damage. Methods results: Dahl salt-sensitive rats were treated orally for 8weeks with normal...
Abstract Affinity of the mineralocorticoid receptor (MR) is similar for aldosterone and glucocorticoids (GC) cortisol corticosterone, which circulate at concentrations far exceeding those aldosterone. 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) inactivation GC within immediate vicinity MR credited with prereceptor specificity in cells coexpressing 11βHSD2. 11βHSD2 efficacy also critical to other recently described substrates. The aim this work was address doubts that low levels...
The aim of this study was to investigate the inhibitory effect Nigella sativa seed extract (abbreviated as NSSE) on adrenaline-induced dyslipidemia and left ventricular hypertrophy (LVH) in rats. Intraperitoneal injection adrenaline for two weeks induced whereas four both LVH significantly, compared with normal Injection NSSE different doses (0.5, 1 1.5 mg/kg body weight, BW) dyslipidemic rats (AIDRs) significantly reduced TC, TG LDL-C increased HDL-C AIDRs most effective dose BW. Treatment...
Background: Somali Region of Ethiopia recorded the first confirmed case SARS-CoV-2 (COVID 19) pandemic on 26 th April 2020.The study aimed to assess effect utilization maternal newborn, child and nutrition health services.Subjects Method: This was a retrospective chart review monthly DHIS database facilities in Farfan zone test association using t used compare mean reduction services three months before (January -March 2020) during (April 2020 June at p value set significant level 5%.The...
Abstract Background Mammalian target of rapamycin (mTOR) inhibitors suppress adrenal cortical carcinoma cell proliferation and cortisol production; the relationship between mTOR aldosterone production has not been examined. Methods HAC15 cells were incubated with an activator several including AZD8055 (AZD) in presence absence angiotensin II (AngII). The expression rapamycin-sensitive adapter protein (Raptor) rapamycin-insensitive companion (Rictor), adaptor proteins complex 1 2,...
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The 2nd Supply and Transport Batallion has the main task of providing supplies, maintenance services by land, water or air. In carrying out its duties, Battalion is still experiencing several issues. Some these issuses caused soldiers’ performance to decline. research aims analyze influence situational leadership style, motivation, work environment on soldier performance. This study will use a quantitative verification analysis, that testing hypothesis through processing field data. Besides...
Portable electronic devices and electric cars use lithium-ion batteries, but clumping lithium alloys limit their lifespan. Due to strong conductivity, volumetric capacity, high energy density, researchers are conducting research on electrochemical metal cells utilizing tellurium for high-performance batteries. Theoretically, lithium-tellurium batteries can improve densities three times more than However, metal-tellurium faces challenges such as low rate capability, unclear redox reactions,...