A5044741959- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Syphilis Diagnosis and Treatment
- Thermochemical Biomass Conversion Processes
- Coal and Coke Industries Research
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Graphene and Nanomaterials Applications
- Alzheimer's disease research and treatments
- Nanoparticles: synthesis and applications
- Glioma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Iron and Steelmaking Processes
- Medicine and Dermatology Studies History
- Mineral Processing and Grinding
- Prion Diseases and Protein Misfolding
- Neurological disorders and treatments
- Nanomaterials for catalytic reactions
- Additive Manufacturing and 3D Printing Technologies
- Calcium signaling and nucleotide metabolism
- Supramolecular Self-Assembly in Materials
Pacific Northwest National Laboratory
2025
The University of Queensland
2022-2025
ARC Centre of Excellence in Advanced Molecular Imaging
2022-2025
Australian Research Council
2022-2023
KIIT University
2021-2023
University of Engineering & Management
2021
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021
National Institutes of Health
2021
National Institute of Technology Arunachal Pradesh
2018-2020
Indian Institute of Technology Bombay
2001-2019
α-Synuclein (α-Syn) aggregation is directly linked with Parkinson's disease (PD) pathogenesis. Here, we analyzed the of newly discovered α-Syn missense mutant H50Q in vitro and found that this mutation significantly accelerates amyloid formation α-Syn. This mutation, however, did not alter overall secondary structure as suggested by two-dimensional nuclear magnetic resonance circular dichroism spectroscopy. The initial oligomerization study cross-linking chromatographic techniques...
Abstract Amyloids are cross-β-sheet fibrillar aggregates, associated with various human diseases and native functions such as protein/peptide hormone storage inside secretory granules of neuroendocrine cells. In the current study, using amyloid detecting agents, we show that growth (GH) could be stored in pituitary rat. Moreover, to demonstrate formation GH vitro , studied conditions (solvents, glycosaminoglycans, salts metal ions) found presence zinc ions (Zn(II)), formed short curvy...
The storage of protein/peptide hormones within subcellular compartments and subsequent release are crucial for their native function, hence these processes intricately regulated in mammalian systems. Several peptide were recently suggested to be stored as amyloids endocrine secretory granules. This leads an apparent paradox where requires formation aggregates, function a supply non-aggregated peptides on demand. precise mechanism behind amyloid by remain open question. To address this, we...
Protein aggregation and amyloid formation are known to play a role both in diseases biological functions. Transcription factor p53 plays major tumor suppression by maintaining genomic stability. Recent studies have suggested that of could lead its loss physiological function as suppressor. Here, we investigated the intrinsic amyloidogenic nature wild-type using sequence analysis. We used bioinformatics prediction algorithms establish evolutionarily conserved aggregation-prone sequences p53....
Enewetak Atoll underwent 43 historical nuclear tests from 1948 to 1958, including the first hydrogen bomb test, resulting in a substantial material fallout contaminating and lagoon waters. The radionuclide deposited sediments soil on islands will remain for decades come. With intensifying climate extreme weather events, possibility of redistribution has become great concern. This study uses numerical modeling approach estimate potential elevated concentrations that can be distributed during...
Abstract Purpose: Receptor CUB-domain containing- protein 1 (CDCP1) was evaluated as a target for detection and treatment of breast cancer. Experimental Design: CDCP1 expression assessed immunohistochemically in tumors from 423 patients (119 triple-negative cancer (TNBC); 75 HER2+; 229 ER+/HER2- including 228 primary tumors, lymph node 47 distant metastases). Cell cytotoxicity induced vitro by CDCP1-targeting antibody-drug conjugate (ADC), consisting the human/mouse chimeric antibody ch10D7...
Recent examples of immune responses directed against the synthetic polymer poly(ethylene glycol) (PEG) have led to development biocompatible polymers, which are viewed as promising candidates act surrogate materials for use in biological applications, such hydrophilic poly(2-oxazoline)s (POx). Despite this, characterization critical aspects response these emerging is sparse, part because no known monoclonal antibodies (mAbs) this family material been reported. To advance understanding...
Pre-targeting of bispecific antibodies is probed to enhance tumour retention while limiting clearance administered multifunctional branched PEGylated nanomedicines. The temporal influence pre-targeting on polymer interaction with cells and tissue explored using in vitro assays through preclinical validation.
Glioblastoma (GBM) is the most aggressive form of primary brain cancer, accounting for about 85% all central nervous system (CNS) tumors. With standard treatment strategies like surgery, radiation, and chemotherapy, median survival time patients with GBM only 12–15 months from diagnosis. The poor prognosis due to a very high tumor recurrence rate following initial treatment, indicating dire need improved diagnostic therapeutic alternatives this disease. Antibody-based immunotheranostics...
Nano drug delivery systems are widely used in cancer treatment nowadays. It is to accomplish a remarkable therapeutic index increase the efficacy of nanocomposites against cells without affecting other cells. Ceramic nanoparticles well-known carry chemotherapeutic drugs infected sites. Interest them aroused by their potential for application as promising biomaterials, especially various orthopaedic applications. In current study, Hydroxyapatite (HAp) was prepared simple situ precipitation...
Covalent DFOB-DOTA dual chelator (‘D2’) binds 89 Zr (DFOB) and 177 Lu (DOTA) regio-selectively enabling Zr– pairing as a novel cancer-targeting theranostic.
AbstractAbstractThe blast furnace has been, and is likely to remain, the dominant technology for ironmaking. Coke fed as a fuel its quality plays significant role in controlling performance of furnace. The coke depends on coal or blend, coking parameters precarbonisation techniques, if any. With decreasing availability increasing cost good hard coal, makers face tough challenge production metallurgical at competitive rates. been enhanced recent times by introduction such compaction blend...
AbstractAbstractThe quality of coke produced in a oven depends on the coal blend characteristics and carbonisation conditions. Scarcity good coking made it necessary to look for techniques capable producing superior from inferior coals. Precarbonisation improve bulk density charge produce The stamp charging technique, most effective among them requires finer crushing higher moisture as binder, both requiring additional energy. JSW Steel has adopted vibrocompaction along with non-recovery...
Covalent conjugation of a biologically stable polymer to therapeutic protein, e.g., an antibody, holds many benefits such as prolonged plasma exposure the protein and improved tumor uptake. Generation defined conjugates is advantageous in applications, range site-selective methods have been reported. Many current coupling lead dispersity efficiencies with subsequent less-well-defined structure, which impacts reproducibility manufacture ultimately may impact successful translation treat or...