A5035196839- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Science, Research, and Medicine
- Protein purification and stability
- Genetic factors in colorectal cancer
- HIV/AIDS drug development and treatment
- Lung Cancer Research Studies
- Mass Spectrometry Techniques and Applications
- Intraperitoneal and Appendiceal Malignancies
- Childhood Cancer Survivors' Quality of Life
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Proteomics Techniques and Applications
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Blood groups and transfusion
- Nutrition, Genetics, and Disease
- Pharmacogenetics and Drug Metabolism
- Lung Cancer Treatments and Mutations
- Palliative Care and End-of-Life Issues
- Bioinformatics and Genomic Networks
- Neuroendocrine Tumor Research Advances
- Family and Patient Care in Intensive Care Units
- Gastrointestinal disorders and treatments
National University Cancer Institute, Singapore
2019-2025
Rio Tinto (Australia)
2016
Rhode Island Hospital
2010-2013
Providence College
2013
Brown University
2010-2013
Center for Cancer Research
2010
Royal Adelaide Hospital
1987-1988
South Australia Pathology
1987-1988
Abstract Purpose: Peritoneal metastases (PM) in colorectal cancer (CRC) portend a poor prognosis. We sought to elucidate molecular features differentiating primary tumors (PTs) from PMs and actionable targets facilitating transcoelomic dissemination progression. Experimental Design: performed multi-omic profiling of 227 samples 136 patients, including 56 tumor (PT) 120 synchronous comprising 34 matched PT-PM pairs. Whole exome, bulk RNA-seq analysis was conducted identify underlying genomic...
Cancer remains a global challenge due to its growing clinical and economic burden. Its uniquely personal manifestation, which makes treatment difficult, has fuelled the quest for personalized strategies. Thus, genomic profiling is increasingly becoming part of diagnostic panels. Effective use such panels requires accurate drug response prediction (DRP) models, are challenging build limited labelled patient data. Previous methods address this problem have used various forms transfer learning....
Objective To investigate the feasibility of using a General Practice registrar (GPR) to coordinate rural palliative care services. Design A quasi-experimental design was used. Intervention group participants received GPR service, which involved liaison among patient, family, Practitioner, specialist team and community nurses. Specified risk assessment, planning continuity were provided. Patients in comparison standard service. Setting Rural care. Participants: One hundred ninety-one patients...
Cancer drug development is proceeding at a rapid pace, with approvals in oncology outpacing the other disease indications. With high population growth and economic of Asian countries, access to cancer drugs becomes paramount necessity. Approval these dependent on establishing their safety efficacy populations living countries. Ethnic racial differences pharmacokinetics, or receptor sensitivities may lead responses between populations. These be due intrinsic extrinsic factors, understanding...
A group of 1615 asymptomatic individuals presumed to be at increased risk colorectal neoplasia were selected as the study group. All tested by an immunochemical test for faecal occult blood. In second half study, who blood negative offered colonoscopy. Ninety‐nine (6.1%) returned stools which positive. Investigation full cotonoscopy was possible in 90 cases, revealing nine patients (10%) with invasive cancers, four (4.4%) carcinomata situ , and 36 (40%) adenomata. Non‐neoplastic pathology...
e14637 Background: The use of Epidermal growth factor receptor (EGFR) inhibitor monotherapy in patients that have KRAS wild type has produced response rates only 10-20%. We propose two possible explanations to explain these low rates; 1) levels resistant CRC cells carrying mutated are below the sensitivity standard direct sequencing modalities (<5%) or 2) practice analyzing a single area within heterogeneous tumor is can overlook areas with KRAS. Methods: In collaborative effort Lifespan...
The results of a screening programme for colorectal neoplasia in high risk group using an immunochemical test blood has been reported recently. This is known as the faecal human haemoglobin (FHH) test. paper reports rescreening this after interval 1–2 years. FHH was compared with disc method. All individuals positive tests were investigated and those negative offered investigation. confirm value group: 19 1153 participants found to have significant neoplasm (1.6%). predictive 42%. A false...