Although topical application of minoxidil is a widely used, FDA-approved therapy for androgenetic alopecia (AGA) treatment, it suffers from low bioavailability, the requirement frequent long-term use, and side effects. With similar structure as minoxidil, kopexil kopyrrol are less toxic have been commercialized, but show an inferior hair regeneration effect compared to minoxidil. Herein, we developed hyaluronic acid (HA)-based dissolvable microneedles (MNs) delivery platform integrated with...

Due to the stratum corneum barrier, resveratrol is difficult be absorbed transdermally, limiting its anti-aging and skin-brightening effects. Furthermore, there a lack of systematic studies on efficacy in human skin, especially three-dimensional skin models clinical trials. To overcome low transdermal delivery issue, we encapsulated into nanoliposomes using high-pressure homogenization method develop an efficient drug system, systematically evaluated via cell line models, model skin. The...

Recent studies have linked disrupted cerebral hemodynamics, including pulsatility index (PI) and wall shear stress (WSS), with neuroimaging features of small vessel disease (CSVD). Cerebral neurovascular coupling (NVC) dysfunction is an important pathophysiological mechanism CSVD. However, evidence linking the carotid artery hemodynamics to NVC still lacking. This study aimed explore impact PI WSS on cognitive performance in CSVD patients using neuroimaging. included 52 41 healthy controls....

Tuberculosis remains a major public health challenge worldwide. This study aimed to determine the long-term trends in notification rate of tuberculosis Zhejiang Province, and assess potential independent risks associated with age, time period, birth cohort. Data on all pulmonary (PTB) cases Province from 2008 2022 were collected Information Management System. Long-term quantitatively decomposed variables determined using joinpoint regression model age-period-cohort model. Between 2022, total...

Abstract Current cardiovascular implantable electronic devices (CIEDs) face a pressing clinical need for the development of battery‐free, biodegradable, and biocompatible to mitigate risk adverse in vivo responses. To address this demand, it is proposed utilizing natural biomaterial, silk sericin (SS), which exhibits valuable biological activities contains abundant asymmetric amino acids with adjustable structures, create an self‐powered system based on piezoelectric principle. The...

Background: Recurrence and distant organ metastasis is a major cause of death in colorectal cancer (CRC); however, the underlying molecular mechanisms regulating this phenomenon are poorly understood. MeCP2 key epigenetic regulator amplified many types cancer. Its role CRC its action remain unknown. Methods: We used western blot immunohistochemistry to detect expression tissues, then investigated biological functions vitro vivo. Chromatin immunoprecipitation, co-immunoprecipitation,...

The helicity of a quadruply stranded M2L4 helicate consisting an aromatic amide bidendate ligand is flexible due to the twisting moieties and can be tuned by encapsulated anions. This study reveals multiple interplays complementarities between anions as well helicate, which are synthetically responsive ultimate conformation helicate.

To determined KIAA1199 expression and investigate its correlation with the clinicopathologic data prognosis of hepatocellular carcinoma (HCC), as well markers epithelial-mesenchymal transition (EMT); N-cadherin, E-cadherin vimentin.Western blot, quantitative real-time PCR, immunohistochemical staining were used to measure in human HCC specimens. Subsequently, between pathological characteristics patients was analyzed. Univariate multivariate analyses explore risk factors associated...

Lycorine is a powerful anti-cancer agent against various cancer cell lines with minor side effects. However, the detailed mechanisms of its effects in colorectal (CRC) remain unclear. In this study, we investigated function and mechanism lycorine CRC both vitro vivo. Molecular docking modeling was used to identify potential inhibitory targets CRC. Cell viability measured using Counting Kit-8 assay, apoptosis flow cytometry. Autophagosomes were examined transmission electron microscopy...

Summary Bamboo with its remarkable growth rate and economic significance, offers an ideal system to investigate the molecular basis of organogenesis in rapidly growing plants, particular monocots, where gene regulatory networks governing maintenance differentiation shoot apical intercalary meristems remain a subject controversy. We employed both spatial single‐nucleus transcriptome sequencing on 10× platform precisely dissect functions various tissues early developmental stages bamboo...

Polycystic ovary syndrome (PCOS) affects 6-20% of women worldwide, with insulin resistance and hyperinsulinemia occurring in 50-70% patients. Hyperinsulinemia exacerbates oxidative stress, contributing to PCOS pathogenesis. N-acetylcysteine (NAC) is an antioxidant sensitizer that shows promise as a therapeutic for PCOS. Our current study aimed investigate the effects NAC supplementation on endocrine-metabolic parameters mice its effect ovulation induction (OI) efficacy

Stress is associated with an increased risk of lung metastasis in melanoma. However, the underlying mechanism elusive. Oxytocin (OXT), a neurohormone produced by hypothalamus, plays vital role laboring induction and lactation. Emerging evidence suggests that OXT also regulates human emotions, social cognition, behaviors stress-related disorders. Here, we reported significant up-regulation oxytocin receptors (OXTRs) was observed malignant The activation OXTRs dramatically promoted migration,...

It is generally accepted that metainflammation, a state of chronic and low-grade inflammation in obesity, plays great role metabolic disorder like insulin resistance. To gain further insight into the mechanism metainflammation find feasible therapy diet-induced obesity (DIO) rats model Electroacupuncture (EA) treatment were established this trail. The results indicated rising Lee's index, hyperlipidemia, resistance, increasing factors including NF-κB, TNF-α, Macrophages 1 determined DIO...

Liver aging impairs the ability of hepatocyte regeneration. Recent studies have found that oxytocin (OT) plays an important role in promoting tissue repair and maintaining differentiation regeneration stem cells. Here, we reported OT receptors, which are specifically located hepatocytes, decrease with human mice. Interestingly, level serum also decline age. Notably, promotes only aged mice but not young vitro vivo. Further reveal autophagy either AML12 mouse hepatocytes or after partial...

Alcoholic liver disease (ALD) is a consequence of heavy and prolonged alcohol consumptions. We previously demonstrated hepatic gamma-aminobutyric acid (GABA) signaling system that protects the from toxic injury. The present study was designed to investigate role GABA in process acute ethanol exposure-induced Our results showed expression synthesizing enzyme glutamic decarboxylase type A receptor (GABAA R) subunits upregulated ethanol-treated mice compared with saline-treated controls....