A5052286489- Advanced materials and composites
- melanin and skin pigmentation
- Tea Polyphenols and Effects
- Skin Protection and Aging
- Seismic Imaging and Inversion Techniques
- Advanced ceramic materials synthesis
- Metal and Thin Film Mechanics
- Plant and animal studies
- Aluminum Alloys Composites Properties
- Magnesium Alloys: Properties and Applications
- Insect and Pesticide Research
- Tribology and Wear Analysis
- Insect and Arachnid Ecology and Behavior
- Hydrogen Storage and Materials
- High Entropy Alloys Studies
- Natural product bioactivities and synthesis
- Biochemical Analysis and Sensing Techniques
- Genomics, phytochemicals, and oxidative stress
- Hydrocarbon exploration and reservoir analysis
- Geochemistry and Geologic Mapping
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Seismic Waves and Analysis
- Drilling and Well Engineering
- Peptidase Inhibition and Analysis
Dalian Medical University
2025
First Affiliated Hospital of Dalian Medical University
2025
Sun Yat-sen University
2023-2024
Zhejiang University
2019-2024
Sun Yat-sen University Cancer Center
2024
Southern University of Science and Technology
2023
Chengdu University of Technology
2019-2023
Lanzhou Institute of Chemical Physics
2019-2023
Chinese Academy of Sciences
2019-2023
University of Chinese Academy of Sciences
2019-2023
Epidermal melanocytes are skin cells specialized in melanin production. Activation of the melanocortin 1 receptor (MC1R) on by α-melanocyte-stimulating hormone (α-MSH) induces synthesis brown/black pigment eumelanin that confers photoprotection from solar UV radiation (UVR). Contrary to keratinocytes, slow proliferating persist for decades, an environment with high levels UVR-induced reactive oxygen species (ROS). We previously reported addition its role pigmentation, α-MSH also reduces...
Fruit rind plays a pivotal role in alleviating water loss and disease particularly cracking resistance as well the transportability, storability shelf-life quality of fruit. High susceptibility to due low hardness is largely responsible for severe annual yield losses fresh fruits such watermelon field during postharvest process. However, candidate gene controlling phenotype remains unclear date. Herein, we report, first time, an ethylene-responsive transcription factor 4 (ClERF4) associated...
Abstract Background Oxaliplatin resistance usually leads to therapeutic failure and poor prognosis in colorectal cancer (CRC), while the underlying mechanisms are not yet fully understood. Metabolic reprogramming is strongly linked drug resistance, however, role mechanism of metabolic oxaliplatin remain unclear. Here, we aim explore functions purine metabolism on oxaliplatin-induced apoptosis CRC. Methods An oxaliplatin-resistant CRC cell line was generated, untargeted metabolomics analysis...
High-entropy carbides are a nascent group of ceramics that promising for high-temperature applications due to the combination good stability, high hardness (<i>H</i>), strength, and superior creep resistance they display. Due melting points low lattice diffusion coefficients, however, high-entropy usually difficult consolidate nearly full density. To cope with this challenge, herein, binary including TiC, V<sub>8</sub>C<sub>7</sub>, NbC, Mo<sub>2</sub>C, WC different carbon stoichiometry...
High-entropy carbides are promising materials as sliding structural components in ultra-high temperature environments due to their good phase stability and excellent mechanical properties. However, the tribological behaviors under coupling conditions of high vacuum environment have not been deeply evaluated. To fill such a gap, high-temperature properties carbon-deficient high-entropy (Zr0.17Nb0.2Ta0.2Mo0.2W0.2)C0.89 (HEC0.89) prepared by using five binary (ZrC, NbC, TaC, Mo2C, WC) starting...
As major regulators on bone formation/resorption in response to mechanical stimuli, osteocytes have shown great promise for restoring injury. However, due the unmanageable and unabiding cell functions unloading or diseased environments, efficacy of osteogenic induction by has been enormously limited. Herein, a facile method oscillating fluid flow (OFF) loading culture is reported, which enables initiate only osteogenesis not osteolysis process. After OFF loading, multiple sufficient soluble...
Acute ischemic stroke (AIS) initiates secondary injuries that worsen neurological damage and hinder recovery. While peripheral immune responses play a key role in outcomes, clinical results from immunotherapy have been suboptimal, with limited focus on T-cell dynamics. Umbilical mesenchymal stem cells (UMSCs) offer therapeutic potential due to their immunomodulatory properties. They can regulate reduce neuroinflammation, potentially enhancing recovery by fostering pro-regenerative...
Triterpene saponins exhibit various biological and pharmacological activities. However, the knowledge on saponin biosynthesis in tea plants (Camellia sinensis L.) is still limited. In this work, flower seed samples at different developmental stages leaves were collected analyzed with UPLC-PDA-MS RNA sequencing for determination transcriptome comparison. The content reached around 19% freshly mature seeds 7% green buds, decreased fruit ripeness blooming. Almost no detected leaf samples. PCA...
Abstract Cubic boron nitride (cBN) with high hardness, thermal conductivity, wear resistance, and chemical inertness has become the most promising abrasive machining material. Due to difficulty of fabricating pure cBN body, generally, some binders are incorporated among particles prepare polycrystalline cubic (PcBN). Hence, play a critical factor performances PcBN composites. In this study, composites three binder systems containing ceramic metal phases were fabricated by spark plasma...
In the early stage of oil and gas exploration, due to lack available drilling data, automatic seismic facies classification technology mainly relies on unsupervised clustering method combined with multiattribute. However, results are unstable have no clear geologic significance. The supervised based manual interpretation can provide corresponding significance, but there still some problems such as discrete low accuracy. To solve these problems, inspired by hyperspectral spatial probability...
Abstract Natural composites have very simple compositions and complex hierarchical architectures consisting of several different levels. These features simultaneously endow them with strength, toughness, functional adaptation, damage‐healing characteristics. Inspired by the microstructural natural materials, this work successfully fabricated Al 2 O 3 /reduced graphene oxide (rGO) fibrous monolithic ceramics bamboo‐like structures introducing a thin around fiber cells to form rGO boundary...
Abstract Background A large number of in vitro experiments have confirmed that DNA molecules can form i-motif advanced structure when multiple cytosines exist the sequence. However, whether these structures are present vivo environment still lacks sufficient experimental evidence. Results In this paper, we report visualization nuclei and chromosomes testis invertebrate Bombyx mori using immunofluorescence staining with an antibody specifically recognizing endogenous transcription factor...