A5063294544- Birth, Development, and Health
- Reproductive Physiology in Livestock
- Adipose Tissue and Metabolism
- Genetic and phenotypic traits in livestock
- Regulation of Appetite and Obesity
- Animal Behavior and Welfare Studies
- Animal Nutrition and Physiology
- Reproductive Biology and Fertility
- Effects of Environmental Stressors on Livestock
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Ovarian function and disorders
- Child Nutrition and Water Access
- Meat and Animal Product Quality
- Biochemical Analysis and Sensing Techniques
- Ruminant Nutrition and Digestive Physiology
- Agricultural and Food Production Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Agriculture Sustainability and Environmental Impact
- Peroxisome Proliferator-Activated Receptors
- Microbial Metabolites in Food Biotechnology
- Nutritional Studies and Diet
- Celiac Disease Research and Management
Universidade da Coruña
2019-2021
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2012-2020
Universidad de la República
2020
Laboratoire de Biologie du Développement
2016-2018
Université Paris-Saclay
2018
Centro Regional de Selección y Reproducción Animal
2009-2018
Universidad Complutense de Madrid
2009-2016
University of Sassari
2012-2015
Université de Tours
2014
The objective of the present study was to determine suitability a swine breed with leptin resistance and predisposition obesity (the Iberian pig) as model for studies on metabolic syndrome type 2 diabetes. Thus, six sows had ad libitum access food enriched saturated fat (SFAD group; consumption estimated be 4.5 kg/animal/day) whilst four females acted controls were fed kg/animal/day commercial maintenance diet. After three months differential feeding, SFAD animals developed central obesity,...
Pregnancy and lactation are challenging states that affect maternal lamb health. In Lacaune dairy sheep, we evaluated the impact of parity, pregnancy rank, body condition on weight ewes lambs in mid-pregnancy (75 ± 5 d), late (142 4d), postpartum (52 5d pp). Maternal age was associated with initial decreases, followed by increases, condition. After lambing, both mature maiden lost indices glucose, protein, lipid metabolism were within physiological values during pregnancy, but depended...
The effects of undernutrition during pregnancy on prenatal and postnatal development the offspring were evaluated in sows with obesity/leptin resistance. Females fed, from day 35 onwards, a diet fulfilling either 100% (group control, n=10) or 50% nutritional requirements underfed, n=10). In control group, maternal body weight increased (P<0.05) while it decreased remained steady underfed group. At days 75 100 gestation, plasma triglycerides lower but urea levels higher restricted than...
At high altitudes, hypoxia, oxidative stress or both compromise sheep fertility. In the present work, we tested relative effect of short- long-term exposure to altitude hypobaric hypoxia and on corpora luteal structure function. The growth dynamics lutea during estrous cycle were studied daily by ultrasonography in cycling that either native naïve high-altitude conditions supplemented not with antioxidant vitamins. Arterial venous blood samples simultaneously drawn for determination gases...
Circulating anti-Müllerian hormone (AMH) and antral follicle count (AFC) are addressed as suitable markers of oocyte quantity quality during adulthood. To investigate whether AFC circulating AMH could predict development the prepubertal period we used 40-day-old ewe lambs with high, intermediate low (≥30, 16-29 and≤15 follicles respectively). The analysis response to exogenous FSH ovarian reserve test showed a positive correlation between AFC, plasma levels, total number large (≥3mm) grown...
Hydroxytyrosol is a polyphenol with antioxidant, metabolism-regulatory, anti-inflammatory and immuno-modulatory properties. The present study aimed to determine whether supplementing the maternal diet hydroxytyrosol during pregnancy can improve pre- early post-natal developmental patterns metabolic traits of offspring. Experiment was performed in Iberian sows fed restricted order increase risk IUGR. Ten were treated daily 1.5 mg per kg feed between Day 35 (30% total gestational period) until...
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there scarcity experimental data on both realistic benefits potential hazards during gestation. Hence, we aimed to swine model IUGR pregnancy determine possible effects maternal with...
Maternal malnutrition during pregnancy, both deficiency and excess, induces changes in the intrauterine environment metabolic status of offspring, playing a key role growth, fitness/obesity appearance disorders postnatal life. There is increasing evidence that these effects may not be only limited to first generation descendants, offspring directly exposed challenges, but subsequent generations. This study evaluated, swine model obesity/leptin resistance, existence extent transgenerational...
The present study evaluated the effectiveness of sildenafil citrate (SC) to improve placental and fetal growth in a diet-induced rabbit model intrauterine restriction (IUGR). Pregnant rabbits were fed either ad libitum (Group C) or restricted 50% dietary requirements R) treated with SC SC). treatment improved development by increasing vascularity vessel hypertrophy decidua. assessment feto-placental haemodynamics showed higher resistance pulsatility indices at middle cerebral artery (MCA)...
Extreme body mass indexes may impair reproductive outcome in assisted technologies. Leptin reflects the amount of fat and could act as a modulator oocyte quality through activation specific transcription factors. The aim this work was to establish whether: 1) leptin influences meiotic cytoplasmic maturation; 2) STAT3 MAPK mediate effects 3) modulates steroid secretion by cumulus-oocyte complexes (COC) during vitro maturation (IVM). We confirmed immunolocalisation receptor oocytes,...
The present study aimed to determine the influence of a glucogenic supply on oocyte developmental competence. Oestrous cycles were synchronised in 22 Sarda ewes by insertion (Day 0) one intravaginal progestagen-impregnated sponge that was removed after 6 days. After removal, randomly allocated into two experimental groups (treated and control ewes) and, from Day 7 11, treated received oral administration mixture, whereas animals water. Follicular development stimulated FSH Days 8 10. Glucose...
The objective of this study was to determine, in a female swine model leptin resistance (Iberian pig), the effect an obesogenic diet, with high saturated fat content, during juvenile period, on appearance early obesity and its possible effects metabolic syndrome-related parameters reproductive features (puberty attainment). Thus, from 130 245 days-old, seven Iberian gilts had ad libitum access food enriched whilst six females acted as controls commercial maintenance diet. Results showed that...
The present study aimed to determine the effects of breed and sex on growth patterns metabolic features advanced-pregnancy foetuses exposed same environmental conditions. Thus, at Day 62 pregnancy, swine from an obese with leptin resistance (Iberian breed) were compared lean crossbred (25% Large White ×25% Landrace ×50% Pietrain). There differential developmental in resistance, mainly a higher relative weight brain resembling "brain-sparing effect". Prioritization may be protective for...
The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days age, we designed this study to determine whether differences found status during early prepubertal period are due patterns activation, and assess these have long lasting effects on subsequent performance. Results showed that with...
This study aimed to determine the effects of piglet birthweight (BIW) and sex, within-litter BIW variation, on postnatal growth traits meat quality in fatty breeds pig. In total, 406 crossbred piglets (half male, half female) born Iberian sows were studied during their development until slaughter. After birth, classified into four categories: very low, medium high. There was a negative effect low patterns acid (FA) composition, but litter size variation not found. The underwent period...
This study assessed the effect of melatonin deprival on ovarian status and function in sheep. Experimental procedures were carried out within two consecutive breeding seasons. Animals divided into groups: pinealectomised (n=6) sham-operated (n=6). The completeness pineal gland removal was confirmed by plasma concentration melatonin. Ovarian monitored ultrasonography for 1 year to reproductive seasonality. Follicular corpus luteal growth dynamics during an induced oestrous cycle. As effects...
In this Research Communication we assessed factors affecting colostrum quality of dairy Lacaune ewes using the Brix-refractometer. Colostrum from 536 lambings one commercial intensive farm were analysed for following with potential influence in quality: (1) ewe parity (n = 84-132), (2) length previous dry period (PDP) 23-214), (3) age at first lambing (AFL) primiparous 9-88), (4) season 192 or 344), and (5) year (2011-2013, n 142-203). Parity significantly affected quality, showing highest...
Contents The Iberian pig is an autochthonous breed of the Mediterranean area, reared extensively in central and southern areas Spain Portugal that known worldwide for production ham. characteristics ham are related to its abundance intramuscular fat, owing high capacity accumulate fat under skin between muscular fibres. This ability store excess enables survival during periods scarcity it has been found other antique animal breeds even humans, being named as thrifty genotype . reproductive...
The incidence of obesity and metabolic diseases is dramatically high in rapidly developing countries. Causes have been related to intrinsic ethnic features with development a thrifty genotype for adapting food scarcity, prenatal programming by undernutrition, postnatal exposure obesogenic lifestyle. Observational studies humans experimental animal models evidence that the adaptive responses offspring may be modulated their sex. In contemporary context world globalization, new question...
Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is highly promising strategy to improve the oxidative metabolic status of fetuses at risk intrauterine growth restriction, which may diminish appearance low-birth-weight neonates. The study aimed determine whether by preventing lipid peroxidation, influence fat accretion energy homeostasis liver, as well fatty acid composition liver muscle. results indicate that hydroxytyrosol treatment...