A5079069933- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Barrier Structure and Function Studies
- Functional Brain Connectivity Studies
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Complex Systems and Time Series Analysis
- Planarian Biology and Electrostimulation
- Laser Applications in Dentistry and Medicine
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Photodynamic Therapy Research Studies
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Photoacoustic and Ultrasonic Imaging
- Traumatic Brain Injury Research
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Chaos control and synchronization
- Ultrasound and Hyperthermia Applications
- Medical and Biological Ozone Research
Saratov State University
2019-2025
Weatherford College
2020
Abstract Intraventricular hemorrhage is one of the most fatal forms brain injury that a common complication premature infants. However, therapy this type limited, and new strategies are needed to reduce hematoma expansion. Here we show meningeal lymphatics pathway remove red blood cells from brain’s ventricular system male human, adult newborn rodents target for non-invasive transcranial near infrared photobiomodulation. Our results uncover clinical significance phototherapy intraventricular...
There is a hypothesis that augmentation of the drainage and clearing function meningeal lymphatic vessels (MLVs) might be promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms photobiomodulation (PBM, 1267 nm) clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence low PBM doses (5 10 J/cm 2 ) stimulate via vasodilation (OCT data on mesenteric lymphatics) stimulation clearance gold nanorods from brain) was...
The deposition of amyloid-β (Aβ) in the brain is a risk factor for Alzheimer's disease (AD). Therefore, new strategies stimulation Aβ clearance from can be useful preventing AD. Transcranial photostimulation (PS) considered promising method AD therapy. In our previous studies, we clearly demonstrated PS-mediated lymphatic clearing functions, including removal brain. There increasing evidence that sleep plays an important role clearance. Here, tested hypothesis PS at night stimulate more...
In this paper, measurements of the optical properties (diffuse reflectance, total and collimated transmittance) brain tissues in healthy rats with C6-glioma were performed spectral range from 350 to 1800 nm. Using these measurements, characteristic tissue parameters, such as absorption coefficient, scattering reduced anisotropy factor reconstructed. It was obtained that 10-day development glioma led increase which associated water content elevation tumor. However, further tumor (formation...
The blood-brain barrier (BBB) limits the delivery of majority cancer drugs and thereby complicates brain tumor treatment. nasal-brain-lymphatic system is discussed as a pathway for drug overcoming BBB. However, in most cases, this method not sufficient to achieve therapeutic effect due short distance. Therefore, it necessary develop technologies overcome obstacles facing nose-to-brain promising pharmaceuticals. In study, we clearly demonstrate intranasal liposomes mouse reaching glioblastoma...
The progress in brain diseases treatment is limited by the blood-brain barrier (BBB), which prevents delivery of vast majority drugs from blood into brain. In this study, we discover unknown phenomenon opening BBBB (BBBO) low-level laser (LLLT, 1268 nm) mouse cortex. LLLT-BBBO accompanied activation drainage system contributing effective liposomes glioblastoma (GBM). LLLT induces generation singlet oxygen without photosensitizers (PSs) endothelial cells and astrocytes, can be a trigger...
Abstract The blood-brain barrier (BBB) has a significant contribution to the protection of central nervous system (CNS). However, it also limits brain drug delivery and thereby complicates treatment CNS diseases. development safe methods for an effective medications nanocarriers can be revolutionary step in overcoming this limitation. Here, we report unique properties lymphatic deliver tracers liposomes meninges, tissues, glioma rats. Using quantum-dot-based 1267 nm laser (for...
Abstract The recently rediscovered meningeal lymphatic system (MLS) opens new insight into pathways of brain clearing and drainage functions that play an important role in neurorehabilitation. development breakthrough strategies for augmentation MLS might be a promising therapeutic target preventing neurological diseases. Here we demonstrate photostimulation (PS, 1268 nm) function healthy male mice. We uncover PS‐mediated increase the mesenteric permeability to fluorescent macrophages via...
A new approach for detection oscillatory patterns and estimation of their dynamics based by a modified CWT skeleton method is presented. The opens up additional perspectives the analysis subtle changes in activity complex nonstationary signals. was applied to analyze unique experimental signals obtained usual conditions after non-invasive increase blood-brain barrier (BBB) permeability 10 male Wistar rats. results wavelet-analysis electrocorticography (ECoG) recorded normal physiological...
In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation peripheral lymphatics, we demonstrate stronger effects photobiomodulation (PBM) brain's drainage system sleeping vs. awake animals. Using Pavlovian instrumental transfer probe 2-objects-location test, found that 10-day course PBM during sleep wakefulness promotes improved learning spatial memory mice. For first time, present technology for under electroencephalographic (EEG)...
Glioblastoma is an incurable and aggressive oncological disease of the brain. Recent studies have shown that transcranial non-invasive photobiomodulation a promising new alternative method for suppression glioblastoma growth. The lymphatic endothelium meningeal vessels important target therapeutic effects photobiomodulation. However, functions decline with age. Therefore, it remains unknown whether can be effective in adults elderly. To answer this question, study examined role brain...
The lymphatic drainage system of the brain (LDSB) is removal metabolites and wastes from its tissues. A dysfunction LDSB an important sign aging, oncology, Alzheimer's Parkinson's diseases. development new strategies for diagnosis injuries can improve prevention age-related cerebral amyloid angiopathy, neurodegenerative cerebrovascular There are two conditions, such as deep sleep opening blood-brain-barrier (OBBB) associated with activation. promising candidate measurement could be...
There is an association between sleep quality and glioma-specific outcomes, including survival. The critical role of in survival among subjects with glioma may be due to sleep-induced activation brain drainage (BD), that dramatically suppressed glioma. Emerging evidence demonstrates photobiomodulation (PBM) effective technology for both the stimulation BD as add-on therapy suggests PBM during stimulates more strongly than when awake. In this study on male Wistar rats, we clearly demonstrate...
Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly neuroscience, neurodegenerative diseases brain tumors. Glioblastoma is most lethal form cancer, with very limited treatment options poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free (PS-free-LT) using quantum-dot-based 1267 nm diode. This wavelength, highly absorbed oxygen,...
Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising alternative strategy for the effective treatment of AD, has been actively discussed over two decades. However, mechanisms therapeutic photostimulation (PS) effects on subjects AD remain poorly understood. The goal this study was to determine PS beta-amyloid (Aβ)-injected mice. neurological severity score object recognition tests demonstrate...
In a series of previous studies, we demonstrated that the photodynamic therapy (PDT), as widely used tool for treatment glioblastoma multiforme (GBM), also site-specifically opens blood–brain barrier (BBB) in PDT-dose and age-related manner via reversible disorganization tight junction machinery. To develop effective protocol PDT-opening BBB, here answer question what kind photosensitizer (PS) is most BBB opening. We studied healthy mice using commercial photosensitizers (PSs) such...