A5010810456- Global Public Health Policies and Epidemiology
- Global Maternal and Child Health
- Global Health Care Issues
- Pulmonary Hypertension Research and Treatments
- Climate Change and Health Impacts
- Health disparities and outcomes
- HIV/AIDS Research and Interventions
- Child Nutrition and Water Access
- Cardiovascular Function and Risk Factors
- Trauma and Emergency Care Studies
- Health Systems, Economic Evaluations, Quality of Life
- Inflammasome and immune disorders
- Neuroscience and Neuropharmacology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV, Drug Use, Sexual Risk
- Healthcare Systems and Reforms
- Cardiovascular Health and Risk Factors
- Mitochondrial Function and Pathology
- Chronic Disease Management Strategies
- Plant Virus Research Studies
- Air Quality and Health Impacts
- Muscle Physiology and Disorders
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Bacteriophages and microbial interactions
University of Pittsburgh
2005-2024
Kaiser Permanente San Jose Medical Center
2021
Hung Vuong Hospital
2021
UC Irvine Health
2020
Center for Vascular Biology Research
2020
University of Pittsburgh Medical Center
2019-2020
VA Greater Los Angeles Healthcare System
2019
Duy Tan University
2016-2018
UPMC Montefiore
2018
Institute for Health Metrics and Evaluation
2016-2017
Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods risk estimates for COPD from the Global Burden of Diseases, Injuries, Risk Factors (GBD) 2015 study. The GBD study provides annual updates on deaths, prevalence, disability-adjusted life years (DALYs), summary measure fatal non-fatal outcomes, over 300 injuries, 188 countries 1990 to most recent year.
<h3>Importance</h3> Liver cancer is among the leading causes of deaths globally. The most common for liver include hepatitis B virus (HBV) and C (HCV) infection alcohol use. <h3>Objective</h3> To report results Global Burden Disease (GBD) 2015 study on primary incidence, mortality, disability-adjusted life-years (DALYs) 195 countries or territories from 1990 to 2015, present global, regional, national estimates burden attributable HBV, HCV, alcohol, an "other" group that encompasses residual...
Government and nongovernmental organizations need national global estimates on the descriptive epidemiology of common oral conditions for policy planning evaluation. The aim this component Global Burden Disease study was to produce prevalence, incidence, years lived with disability from 1990 2017 by sex, age, countries. In addition, reports socioeconomic pattern in burden standard World Bank classification economies as well Socio-demographic Index. findings show that remain a substantial...
Dysfunction of inhibitory neurons in the prefrontal cortex (PFC), represented by decreased expression GABA-related genes such as 67 kDa isoform glutamate decarboxylase (GAD ) and parvalbumin (PV), appears to contribute cognitive deficits subjects with schizophrenia. We investigated involvement signaling mediated brain-derived neurotrophic factor (BDNF) its receptor tyrosine kinase TrkB producing altered gene In 15 pairs schizophrenia matched control subjects, both BDNF mRNA levels, assessed...
We examined the association of alcohol use disorders (AUD) with adherence to and health-related quality life (HRQOL) outcomes antiretroviral treatment (ART) for HIV/AIDS patients.A cross-sectional multi-site survey was conducted in 468 drug users 648 non-drug (age: 35.4 ± 7.0 years; 63.8% male) 3 epicentres Vietnam. AUD, ART adherence, HRQOL were measured using Alcohol Use Disorders Identification Test - Consumption (AUDIT-C), self-reported Visual Analogue Scale (VAS), World Health...
In regenerative medicine, a synthetic extracellular matrix is crucial for supporting stem cells during its differentiation process to integrate into surrounding tissues. Hydrogels are used extensively in biomaterials as matrices support the cells. However, mimic biological niche of functional tissue, various chemical functionalities necessary. We present here, method functionalizing highly porous hydrogel with groups by mixing plant virus, tobacco mosaic virus (TMV), and mutant. The...
Accumulating evidence suggests that altered cellular metabolism is systemic in pulmonary hypertension (PH) and central to disease pathogenesis. However, bioenergetic changes PH patients their association with severity remain unclear. Here, we hypothesize alteration function present platelets from correlates clinical parameters of PH. Platelets isolated controls (n = 28) were subjected extracellular flux analysis determine oxygen consumption glycolytic rates. showed greater rates than...
The adaptation of single fibers in medial gastrocnemius (MG), a fast-twitch extensor, and tibialis anterior (TA), flexor, was studied after 14 days spaceflight (COSMOS 2044) or hindlimb suspension. Cross-sectional area (CSA) succinate dehydrogenase (SDH), alpha-glycerophosphate (GPD), myofibrillar adenosinetriphosphatase (ATPase) activities were determined identified frozen serial cross sections. Fibers categorized as light, dark, intermediate on the basis myosin ATPase staining alkaline...
Diarrheal diseases (DD) are leading causes of disease burden, death, and disability, especially in children low-income settings. DD can also impact a child's potential livelihood through stunted physical growth, cognitive impairment, other sequelae. As part the Global Burden Disease Study, we estimated burden attributable to specific risk factors particular etiologies, Eastern Mediterranean Region (EMR) between 1990 2013. For both sexes all ages, calculated disability-adjusted life years...
The ability of Tobacco mosaic virus (TMV) to tolerate various amino acid insertions near its carboxy terminus is well-known. Typically these inserts are based on antigenic sequences for vaccine development with plant viruses as carriers. However, we determined that the structural symmetries and size range could also be modeled mimic extracellular matrix proteins by inserting cell-binding coat protein. play important roles in guiding cell adhesion, migration, proliferation, stem...
Mobile phone use in Vietnam has become increasingly popular recent years, with youth (people aged 15-24 years) being one of the groups heaviest use. Health-related apps on mobile phones (mobile health [mHealth] apps) appear to be a feasible approach for disease and management, especially self-management. However, there been scarcity research usage care among adolescents.This study aims identify patterns preferences functionalities phone-based health-related Vietnamese youth.An online...
Reduced heart rate recovery (HRR) after exercise is associated with increased mortality in cardiac and pulmonary diseases. We sought to evaluate the association between HRR 6-minute walk test (6MWT) outcomes patients connective tissue disease-associated hypertension (CTD-PH). Data were obtained by review of medical records. was defined as difference at end 6MWT 1 minute (HRR1), 2 minutes (HRR2), 3 (HRR3) rest. All a diagnosis systemic sclerosis, lupus erythematosus, or mixed disease who...
Abstract Allosteric modulation by neuroactive steroids of radioligand binding sites on the GABA A receptor complex was demonstrated autoradiography in vitro several regions human brain and effects compared to those rat brain. Comparing rat, two known be active enhancing GABA‐mediated postsynaptic inhibition, 5α‐pregnane‐3α21‐diol‐20‐one (tetrahydro‐deoxycorticosterone, THDOC) alphaxalone (5α‐pregnane‐3α‐hdyroxy‐11,20‐dione), allosterically inhibited [ 35 S]TBPS picrotoxin/convulsant site...
Viruses are monodispersed biomacromolecules with well-defined 3-D structures at the nanometer level. The relative ease to manipulate viral coat protein gene display numerous functional groups affords an attractive feature for these nanomaterials, and inability of plant viruses infect mammalian hosts poses little or no cytotoxic concerns. As such, nanosized molecular tools serve as powerful templates many pharmacological applications ranging multifunctional theranostic agents tissue targeting...
Pulmonary hypertension (PH) is characterized by elevated pulmonary artery pressure but classified into subgroups based on disease etiology. It established that systemic bioenergetic dysfunction contributes to the pathogenesis of arterial as World Health Organization (WHO) Group 1. Consistent with this, we previously showed platelets from 1 PH patients demonstrate increased glycolysis and enhanced maximal capacity for oxidative phosphorylation, which due fatty acid oxidation (FAO). However,...
Viral load testing is considered the gold standard for monitoring HIV treatment; however, given its high cost, some patients cannot afford viral if this not subsidized. Since foreign aid HIV/AIDS in Vietnam rapidly decreasing, we sought to assess willingness pay (WTP) and CD4 cell count tests among HIV-positive patients, identified factors that might inform future co-payment schemes.A multi-site cross-sectional survey was conducted with 1133 on antiretroviral therapy (ART) Hanoi Nam Dinh....
Health insurance (HI) plays an important role in ensuring the financial equity by risk pooling mechanism and reducing economic burden of healthcare for HIV/AIDS patients. However, there is a lack evidence to clearly understand HI coverage regard people living with HIV (PLWH). We conducted this study explore barriers among PLWH Vietnam.A cross- sectional was multi-sites including 3 hospitals 5 outpatient clinics Hanoi Nam Dinh 2013. A convenience sampling approach used recruit participants....
The role of neuromuscular activity in maintaining the normal enzyme heterogeneity found a predominantly fast mixed muscle was studied. Enzymatic profiles single fibers adult cat medial gastrocnemius (MG) were examined after almost complete elimination for 6 mo. Inactivity achieved by spinal cord isolation (SI), i.e., transection at T12-T13 and L7-S1 combined with bilateral dorsal rhizotomy between two sites. Cross-sectional area succinate dehydrogenase (SDH) alpha-glycerophosphate (GPD)...
Ensuring high enrollment while mobilizing resources through co-payment services is critical to the success of methadone maintenance treatment (MMT) program in Vietnam. This study assessed willingness patients pay (WTP) for different MMT delivery models and determined its associated factors. A facility based survey was conducted among 1016 (98.7% male, 42% aged 35 or less, 67% living with spouse) five clinics Hanoi Nam Dinh province 2013. Socioeconomic, HIV health status, history drug use...
Abstract Context Medication deprescribing in palliative care settings has been insufficiently studied. Objective To determine the feasibility of a program hospice patients with limited life expectancy. Design Pharmacist‐led, single arm, single‐centered, retrospective analysis pilot an integrated healthcare delivery organization between 9/1/2018 to 1/31/2019. Outcome measures The primary outcome was proportion who achieved ≥50% reduction recommended medications deprescribe. Results A total 97...
Study Objective Despite evidence that supports the use of sacubitril/valsartan – first angiotensin II receptor blocker–neprilysin inhibitor for mortality reduction in patients with heart failure ( HF ), it remains underprescribed. The objective this study was to evaluate eligibility initiation treatment within largest Veterans Administration healthcare system United States. Design Cross‐sectional study. Setting Affairs Greater Los Angeles Healthcare System VAGLAHS ). Patients A total 2985 a...
ABSTRACT The right and left ventricle of the heart have distinctly different developmental origins are affected differently by similar pathological stimuli. Though it is well established that relies almost entirely on mitochondrial function to sustain energy production, remains unclear whether bioenergetics differ in two ventricles. Herein, we define a novel methodology optimize isolation intact cardiomyocytes from versus ventricle. We demonstrate this segmental Langendorff-free yields...