A5020618614- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Healthcare cost, quality, practices
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Cardiac Imaging and Diagnostics
- Gestational Diabetes Research and Management
- Biosensors and Analytical Detection
- Respiratory Support and Mechanisms
- COVID-19 diagnosis using AI
- Trauma and Emergency Care Studies
- Congenital heart defects research
- Mechanical Circulatory Support Devices
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Data-Driven Disease Surveillance
- Coronary Artery Anomalies
Manchester University NHS Foundation Trust
2019-2024
University of Southampton
2012-2021
St. Mary's Hospital
2020
St Mary's Hospital
2020
Institute of Developmental Physiology
2017
MRC Lifecourse Epidemiology Unit
2016
Princess Anne Hospital
2012
University Hospital Southampton NHS Foundation Trust
2012
Colgate-Palmolive (Switzerland)
1956
We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus RXRA offspring bone mass. In this study, we used an existing randomized trial to test hypothesis that gestational vitamin supplementation would lead reduced methylation. The Maternal Vitamin Osteoporosis Study (MAVIDOS) was a multicenter, double-blind, randomized, placebo-controlled of 1000 IU/day cholecalciferol or matched...
Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later life, a relationship that may part be mediated through altered epigenetic regulation genes. We previously identified region within promoter long non-coding RNA ANRIL encoded by CDKN2A locus, at which differential DNA methylation birth showed correlations offspring adiposity. Given common lineage adipocytes osteoblasts, we investigated between perinatal bone mass ages 4 6 years. Using sodium...
Background Rapid diagnostic tests (RDTs) developed for point of care detection SARS-CoV-2 antigen are recommended by WHO to use trained health workers collect samples. We hypothesised that self-taken samples non-inferior with RDTs diagnose COVID-19. designed a prospective evaluation comparing and healthcare worker (HCW)-taken throat/nasal swabs perform SARS-CoV-2, how these compare RT-PCR. Methods Eligible participants 18 years or older symptoms 250 recruited at the NHS Test Trace...
Introduction Within the UK, chest pain is one of most common reasons for emergency (999) ambulance calls and reason hospital admission. Diagnosing acute coronary syndromes (ACS) in a patient with prehospital setting by paramedic challenging. The Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision rule validated tool used department (ED) to stratify patients suspected ACS following single blood test. We are seeking evaluate diagnostic accuracy T-MACS aid algorithm ‘rule out’...
Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated concurrent adiposity measures and examined whether these were hsCRP, adipokines, early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants years, identified 29 dmCpGs (Bonferroni corrected p < 1.06E-07) body mass index (BMI), 10 waist circumference (WC) 9 subcutaneous fat thickness. DmCpGs within Ras...
In response to the global COVID-19 pandemic, many in vitro diagnostic (IVD) tests for SARS-CoV-2 have been developed. Given urgent clinical demand, researchers must balance desire precise estimates of sensitivity and specificity against need rapid implementation. To complement precision used sample size calculations, we aimed estimate probability that an IVD will fail perform expected standards after implementation, following studies with varying sizes.We assumed validation study met...
Objectives The Manchester Acute Coronary Syndromes ECG (MACS-ECG) prediction model calculates a score based on objective measurements to give the probability of non-ST elevation myocardial infarction (NSTEMI). showed good performance in emergency department (ED), but its accuracy pre-hospital setting is unknown. We aimed externally validate MACS-ECG environment. Methods undertook secondary analysis from Pre-hospital Evaluation Sensitive Troponin (PRESTO) study, multi-centre prospective study...
The purpose of this study is to develop a theory-driven understanding the barriers and facilitators underpinning physicians' attitudes capabilities implementing SARS-CoV-2 point-of-care (POC) testing into primary care practices.We used secondary qualitative analysis approach re-analyse data from qualitative, interview 22 physicians 21 practices across three regions in England. We followed three-step method based on Behaviour Change Wheel identify POC identified strategies address these...
Objectives In order to generate independent performance data regarding accuracy of COVID-19 antigen-based rapid diagnostic tests (Ag-RDTs), prospective evaluation studies across multiple sites are required evaluate their in different clinical settings. This report describes the GENEDIA W Ag Device (Green Cross Medical Science Corp., Chungbuk, Korea) and ActiveXpress+ Complete Testing Kit (Edinburgh Genetics Ltd, UK), two testing Peru United Kingdom. Methods Nasopharyngeal swabs collected...
descriptive data on rates of total hip (THR) and knee replacement (TKR) within a large national cohort incident RA patients describe the potential influence age, sex, geographic region socio-economic status.Methods: Patients with first diagnosis between 1995 2013 were identified from Clinical Practice Research Datalink (CPRD).Those diagnoses multiple types inflammatory arthritis excluded.First occurrence subsequent primary THR TKR using validated (to hospital records) Read code lists...
Abstract Objectives To compare self-taken and healthcare worker (HCW)-taken throat/nasal swabs to perform rapid diagnostic tests (RDT) for SARS-CoV-2, how these RT-PCR. We hypothesised that samples are non-inferior use with RDTs in clinical research settings could have substantial individual public health benefit. Design A prospective accuracy evaluation as part of the ‘Facilitating Accelerated Clinical Evaluation Novel Diagnostic Tests COVID -19 (FALCON C-19), workstream C (undifferentiated...
The COVID-19 pandemic has given rise to numerous commercially available antigen rapid diagnostic tests (Ag-RDTs). To generate and share accurate independent data with the global community requires multisite prospective evaluations of Ag-RDTs. This report describes clinical evaluation OnSite test (CTK Biotech, CA, USA) in Brazil United Kingdom. A total 496 paired nasopharyngeal (NP) swabs were collected from symptomatic health care workers at Hospital das Clínicas São Paulo, Brazil, 211 NP...
<h3>Introduction</h3> Transient Neonatal Diabetes Mellitus (TNDM) due to genetic aberrations at 6q24 is the commonest cause of diabetes presenting within first week life. It affects between 1:200,000 and 1:400,000 live births with majority infants born small for gestation age. TNDM predisposes mellitus in later We report on clinical presentation largest worldwide cohort cases. <h3>Results</h3> 164 cases were analysed. The mean age was 8 days a mode 1 day maximum 90 days. On average, babies...
Background: Obesity predisposes to cardiovascular disease, itself influenced by perinatal factors. Epigenetics is hypothesized link influences with later obesity. We aimed identify, using an epigenome wide association study, differentially methylated CpGs measured at 17-years-old that associated concurrent adiposity, then ascertain whether the strongest of these associations were stable over time, between generations, and mediated early life environment body composition. Methods: Genome-wide...