A5004040780- Luminescence and Fluorescent Materials
- Analytical Chemistry and Sensors
- X-ray Diffraction in Crystallography
- Biosensors and Analytical Detection
- Crystallization and Solubility Studies
- Laser-Matter Interactions and Applications
- RNA Research and Splicing
- Molecular Sensors and Ion Detection
- Laser-Plasma Interactions and Diagnostics
- Atomic and Molecular Physics
- Optical Imaging and Spectroscopy Techniques
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Advanced Chemical Physics Studies
- Photochemistry and Electron Transfer Studies
- Quantum Dots Synthesis And Properties
- Nuclear Structure and Function
- Mesoporous Materials and Catalysis
- Zeolite Catalysis and Synthesis
- Quantum, superfluid, helium dynamics
- PI3K/AKT/mTOR signaling in cancer
- Porphyrin and Phthalocyanine Chemistry
- Organic Light-Emitting Diodes Research
- Cold Atom Physics and Bose-Einstein Condensates
Martin Luther University Halle-Wittenberg
2011-2024
Heidelberg University
2012-2022
University Hospital Heidelberg
2012-2022
Federal Institute For Materials Research and Testing
2011-2021
Luther University
2021
PYC Therapeutics (Australia)
2018
The Kids Research Institute Australia
2003-2018
The University of Western Australia
2007-2018
Medizinische Hochschule Hannover
2014
German Cancer Research Center
2014
The combination of nanomaterials as solid supports and supramolecular concepts has led to the development hybrid materials with improved functionalities. These "hetero-supramolecular" ideas provide a means bridging gap between molecular chemistry, sciences, nanotechnology. In recent years, relevant examples have been reported on functional aspects, such enhanced recognition sensing by using molecules preorganized surfaces, reversible building nanometer-sized networks 3D architectures, well...
Vector momentum distributions of Ne(n+) (n = 1,2,3) ions created by 30 fs, approximately 1 PW/cm(2) laser pulses at 795 nm have been measured using recoil-ion spectroscopy. Distinct maxima along the light polarization axis are observed 4.0 and 7.5 a.u. for Ne2+ Ne3+ production, respectively. Hence, mechanisms based on an instantaneous release two (or more) electrons can be ruled out as a dominant contribution to nonsequential strong-field multiple ionization. The positions in accord with...
The use of microarray technology to assess gene expression levels is now widespread in biology. validation results using independent mRNA quantitation techniques remains a desirable element any experiment. To facilitate the comparison data between laboratories it essential that methodologies be critically examined. We have assessed correlation scores obtained for 48 human genes oligonucleotide microarrays and same measured by quantitative real-time RT-PCR (qRT-PCR). Correlations with qRT-PCR...
A strategy for the rational design of a new optical sensor material selective recognition long-chain carboxylates in water is presented. The approach relies on combination structure−property relationships to single out optimal molecular unit and tuning sensing characteristics an inorganic support material. spacer-substituted 7-urea-phenoxazin-3-one was employed as signaling moiety mesoporous trimethylsilylated UVM-7 (MCM-41 type) served solid support. shows advantageous features both modules...
Valproic acid (VPA) is a widely used antiepileptic agent that undergoing clinical evaluation for anticancer therapy. We assessed the effects of VPA on angiogenesis in vitro and vivo. In human umbilical vein endothelial cells, therapeutically relevant concentrations (0.25 to 1 mM) inhibited proliferation, migration, tube formation. mM cell proliferation by 51 ± 5%, migration 86 11%, formation 82 3%. These changes were preceded hyperacetylation histone H4, indicating inhibition deacetylase...
A new class of boron−dipyrromethene (BDP or BODIPY) dyes was obtained by phenanthrene fusion to the β-pyrrole positions, absorbing in wavelength range important laser sources. Despite a 'propeller-like' distorted structure crystalline state, chromophore absorbs (log ε ≥ 5) and fluoresces (Φf 0.8) strongly can be easily turned into fluorescence light-up probe. Incorporation latex beads produces bright photostable single-dye Förster Resonance Energy Transfer (FRET) particles for microscopy...
To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well expression data from a cohort of well-characterized hepatocellular carcinomas (HCCs). Bisulfite-converted DNAs 63 HCCs 10 healthy control livers were analyzed the status more than 14,000 genes. After defining differentially methylated genes in HCCs, integrated their...
Abstract Summary: We have generated the program easyLINKAGE that combines automated setup and performance of linkage analyses simulation under an easy to handle graphical user interface for Microsoft Windows 2000/XP standard UNIX systems. The package supports two-point (FastLink v4.1 SPLink v1.09), multi-point [GENEHUNTER v2.1, GENEHUNTER-PLUS with emendation by Kong Cox v1.2 (allele sharing modelling)] SLINK v2.65, provides genome-wide as well chromosomal postscript plots LOD scores, NPL...
Summary: We extended the original easyLINKAGE program by enabling linkage analyses for large-scale SNP data in addition to those of microsatellites. implemented new modules Allegro, Merlin, SimWalk, GeneHunter Imprinting, TwoLocus, SuperLink and FastSLink automatic loop breaking outputs. added conditional as well multipoint simulation studies, error test routines checking Mendelian/non-Mendelian genotyping errors deviations from Hardy–Weinberg equilibrium. Data can be analyzed sets markers,...
The photoelectron spectra of C60 ionized using a 790 nm laser with pulse durations varying from 25 fs to 5 ps have been determined. For pulses, in the absence fragmentation, ionization mechanism is direct multiphoton clear observation above threshold ionization. As duration increased, this becomes dominated by statistical due equilibration among electronic degrees freedom. on order coupling vibrational freedom occurs and well-known phenomenon delayed (&mgr;s) observed.
The amount of grafted poly(acrylic acid) on poly(methyl methacrylate) micro- and nanoparticles was quantified by conductometry, (13)C solid-state NMR, fluorophore labeling, a supramolecular assay based high-affinity binding cucurbit[7]uril, two colorimetric assays toluidine blue nickel complexation pyrocatechol violet. methods were thoroughly validated compared with respect to reproducibility, sensitivity, ease use. results demonstrate that only small but constant fraction the surface...
Using cortical neuronal cultures and glutamic acid excitotoxicity oxygen-glucose deprivation (OGD) stroke models, we demonstrated that poly-arginine arginine-rich cell-penetrating peptides (CPPs), are highly neuroprotective, with efficacy increasing arginine content, have the capacity to reduce acid-induced calcium influx require heparan sulfate preotoglycan-mediated endocytosis induce a neuroprotective effect. Furthermore, neuroprotection could be induced immediate peptide treatment or up 2...
Explosions of large Xe clusters (<N> ~ 11,000) irradiated by femtosecond pulses 850 eV x-ray photons focused to an intensity up 10(17) W/cm(2) from the Linac Coherent Light Source were investigated experimentally. Measurements ion charge-state distributions and energy spectra exhibit strong evidence for formation a nanoplasma in intense pulse. This produced is accompanied three-body recombination hydrodynamic expansion. These experimental results appear be consistent with model which...
Overexpression of MYC oncogene is highly prevalent in many malignancies such as aggressive triple-negative breast cancers (TNBCs) and it associated with very poor outcome. Despite decades research, attempts to effectively inhibit MYC, particularly small molecules, still remain challenging due the featureless nature its protein structure. Herein, we describe engineering dominant-negative peptide (OmoMYC) linked a functional penetrating 'Phylomer' (FPPa) therapeutic strategy TNBC. We found...