This study aims to analyze the use of sedative-hypnotic drugs among children and adolescents in a hospital setting, providing reference for optimizing drug use. A retrospective analysis was conducted on prescription data aged 6-18 years from 2018 2023 at outpatient department hospital. Data were organized using Excel analyzed statistical software such as SPSS, with descriptive statistics independent samples t-tests used medication patterns across different age groups genders. The majority...

Previous studies have found that Astragalus Polysaccharide (APS) and Lactobacillus plantarum PS128 (PS128) potential antidepressant effects, but their effects on the gut microbiota metabolites of major depressive disorder (MDD) are still unclear. We examined effect APS first-episode drug naïve MDD patients using in vitro fermentation, further explored whether could enhance utilization ability APS. Fresh fecal samples from 15 were collected, analyzed for differences gas production,...

AIM:To investigate the prognostic significance of phosphatase regenerating liver 3 (PRL-3) protein expression in gastric cancer.METHODS: PRL-3 paraffin-embedded tumor specimens from 293 patients with cancer was studied retrospectively by immunohistochemistry. Monoclonal antibody specifically against PRL-3, 3B6, obtained hybridoma technique. RESULTS:Positive detected 43.3% (127 293) cases.High positively correlated size, depth invasion, vascular/lymphatic lymph node metastasis, high TNM stage...

Osteopontin has been shown to facilitate the progression and metastasis of malignancies be prognostic value in several human cancers. In gastric cancer, protein expression osteopontin found correlated with tumor invasion metastasis, but data on its are lacking. The aim this study was classify significance cancer.In retrospective study, 306 tissue samples resected from patients cancer were investigated by staining a commercial polyclonal antibody against osteopontin.Positive (>5% cell...

There has historically been women underrepresentation on editorial boards of peer-reviewed medical journals. High-ranked oncology journals showcase cancer-related scientific work at the forefront discipline. is urgent need to investigate gender representation leading journals.Sixty high-ranked based impact factor calculated by Journal Citation Reports (JCR) 2021 from Web Science/Clarivate Analytics were identified. Gender-related information was obtained each journal's website. The member...

Abstract Introduction Electroacupuncture protects neurons and myelinated axons after spinal cord injury by mitigating the inflammatory response oxidative stress, but how it exerts these effects is unclear. Methods results Spinal was induced in C57BL/6 wild‐type apolipoprotein E (ApoE) knockout ( ApoE –/– ) mice, followed electroacupuncture or mimetic peptide COG112 treatment. Mice with suffered loss of hindlimb motor function through detections Basso mouse scale, histology, transmission...

To observe the effect of electroacupuncture (EA) on expression apolipoprotein E (ApoE) and related proteins inflammation anti-oxidative stress in spinal cord mice with injury (SCI), so as to explore its mechanisms underlying function repair.Thirty-six female C57BL/6 were equally randomized into 3 groups: sham operation, model EA. The SCI was established by clamping for 25 s a serrefine after laminectomy 1st lumbar vertebra (L1). EA (1.5 Hz/7.5 Hz, 1.0 mA) applied bila-teral "Zusanli" (ST36)...

We have entered an open access publishing era. The impact and significance of is still under debate after two decades evolution. Open journals benefit researchers the general public by promoting visibility, sharing communicating. Non-mainstream should turn challenge into opportunity presenting best research articles to global readership. need optimize their business models promote healthy continuous development.

China has a low level of fertility after many years births control by government intervention. Challenged an aging and low-fertility population, China's one-child policy was abolished in 2013 two Quantitative Easing Population Policies (QEPP) implemented its stead. Based on study population evolutions eastern provinces China, this paper analyzes the local factors affecting birthrate shows that social development certain other variables significantly impact rates. Thus, QEPP alone cannot...

This study was designed to investigate the association of IL-8-251 T > A gene polymorphism with clinicopathological features and prognostic role in patients gastric adenocarcinoma. The detected by polymerase chain reaction–restriction fragment length method, followed univariate multivariate analyses elicit its role. frequency A/A, A/T T/T genotypes were 11.0% (23/210), 43.8% (92/210) 45.2% (95/210), respectively. closely correlated depth invasion (p = 0.007), grade differentiation 0.002) TNM...

There is urgent need for medical journals to optimize their publishing processes and strategies satisfy the huge scientists publish articles, then obtain better prestige impact in scientific research community. These include optimizing process of peer-review, utilizing open-access models actively, finding ways saving costs getting revenue, smartly dealing with fraud or misconduct, maintaining sound relationship pharmaceutical companies, managing provide relevant useful information clinical...

OBJECTIVE To observe the effect of electroacupuncture (EA) at Jiaji (EX-B2) on levels autophagy and endoplasmic reticulum stress in mice with spinal cord injury (SCI), so as to explore its mechanism underlying improvement SCI. METHODS A total 60 female C57BL/6 were randomly divided into sham operation, model EA groups， which further 7 d 14 subgroups (10 each subgroup). The SCI was established by pressing exposed (L1) a vascular clamp for 15 s. applied bilateral EX-B2 3 h after modeling, once...

To observe the effect of electroacupuncture(EA)on locomotor activity and expression high-mobility group box-1(HMGB1) Toll-like receptor 4(TLR4) in mice with spinal cord injury(SCI), so as to explore its mechanisms underlying improvement SCI at acute stage.Forty-eight female C57BL/6 were equally randomized into 3 groups: sham operation, model EA. The was established by clamping a serrefine after laminectomy 1st lumbar vertebra(L1). EA (1.5 Hz/7.5 Hz, 1.0 mA) applied "Jiaji"(EXH-B2) for 10...

Depression is one of the major disease burdens worldwide. Few studies have addressed body mass index (BMI) in Chinese depression patients. This current study aimed to investigate BMI patients with and correlation clinical factors. A total 211 inpatients first-episode were enrolled. General data collected by standardized questionnaires levels hemoglobin, fasting blood glucose, uric acid, lipid measured. In total, 24-item Hamilton Scale (HAMD) 14-item Anxiety (HAMA) rated for all The was 37...

BACKGROUND It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence surgical intervention. Several recent clinical studies have shown multi-tract percutaneous nephrolithotomy (M-PCNL) has a similar stone free rate (SFR) as standard (S-PCNL). As result, M-PCNL was also recommended treatment option for staghorn calculi. AIM To examine perioperative long-term results ultrasonography-guided single- M-PCNL. METHODS This retrospective...

Background: This study was designed to investigate the prognostic role of MMP-7-181A/G gene polymorphism in patients with gastric cancer and correlate genotype clinicopathological features.Methods: The polymerase chain reaction-restriction fragment length (PCR-RFLP) method used detect polymorphism, analyses were performed elucidate polymorphism.Results: MMP-7-181A/A detected 83.8% (176/210) cases, A/G 16.2% (34/210) cases G/G 0% (0/210) cases. closely correlated lymph node metastasis...

To observe the effect of electroacupuncture (EA) combined with transplantation Schwann cells (SCs) on limb locomotor, myelin sheath repair and expression CD4 CD8 in compressed spinal cord injury (CSCI) rats, so as to explore its mechanisms underlying improvement CSCI.A total 45 female SD rats were randomly divided into normal control, model, EA, cell (SC) transplantation, EA＋SC groups (n＝9 each group). The CSCI model was established by laminectomy at T12-L2 clip compression. Rats SC group...

Abstract Background: Spinal cord injury (SCI) is a catastrophic central nervous system disease. Inflammatory response and oxidative stress are two critical factors in the pathophysiological process of SCI closely involved with Apolipoprotein E(ApoE) Nuclear factor erythroid 2-related (Nrf2). Electroacupuncture (EA) has perfectly neuroprotective effect on SCI. However, underlying mechanism by which EA mediates inflammatory not completely elucidated. In present study, we investigated signaling...

To explore the correlation between Cdx2 expression and clinicopathologic features of patients with gastric carcinoma, to evaluate role as a prognostic indicator carcinoma. The was studied using immunohistochemistry paraffin-embedded tumor specimens from 154 who underwent D2 resection for adenocarcinoma 1994 1998. detected in 35.1% (54 154) carcinoma cases. Expression significantly higher intestinal-type carcinomas than diffuse-type carcinomas, cases TNM stage I II those III IV (P<0.001...