A5089401667- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Animal Virus Infections Studies
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Virology and Viral Diseases
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Microbial infections and disease research
- Parvovirus B19 Infection Studies
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
École Nationale Vétérinaire de Toulouse
2021-2024
Université de Toulouse
2021-2024
Interaction Hôtes Agents Pathogènes
2021-2023
Département Santé Animale
2023
Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of recombinant IFNs as therapeutics against SARS-CoV-2 infection. In Syrian hamster model, we show that intranasal administration IFN-α starting one day pre-infection post-infection limited weight loss and decreased viral lung titers. By contrast, at onset symptoms three days had no impact on clinical course Our results provide evidence early IFN treatment is...
Avian influenza A(H5N8) virus has caused major epizootics in Europe since 2016. We conducted virologic analysis of aerosol and dust collected on poultry farms France during 2020-2021. Our results suggest contributes to viral dispersal, even early an outbreak, could be a valuable surveillance tool.
Concurrent infections with multiple pathogens are often described in cattle respiratory illness. However, how the host-pathogen interactions influence clinical outcome has been only partially explored this species. Influenza D virus (IDV) was discovered 2011. Since then, IDV detected worldwide different hosts. A significant association between and bacterial sick shown epidemiological studies, especially Mycoplasma bovis. In an experimental challenge, aggravated M. bovis-induced pneumonia....
Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize single-stranded RNA. TLR7 loss-of-function mutants are associated with life-threatening pneumonia in severe COVID-19 patients. Whereas TLR7-driven innate induction of type I IFN appears central control SARS-CoV2 virus spreading during the first days infection, impact TLR7-deficiency on adaptive B-cell immunity is less clear. In present study, we examined role B cells response various...
Abstract High pathogenicity avian influenza viruses (HPAIVs) have caused major epizootics in recent years, with devastating consequences for poultry and wildlife worldwide. Domestic wild ducks can be highly susceptible to HPAIVs, infection leads efficient viral replication massive shedding (i.e., high titres an extended time), contributing widespread dissemination. Importantly, are known shed amounts of virus the earliest phase infection, but dynamics impact environmental contamination on...
Abstract Highly Pathogenic Avian Influenza viruses (HPAIVs) display a tissue pantropism, which implies possible spread in feathers. HPAIV detection from feathers had been evaluated for H5N1 or H7N1 HPAIVs. It was suggested that viral RNA loads could be equivalent higher samples of immature feather compared to tracheal (TS) cloacal swabs (CS). We investigated the suitability clade 2.3.4.4b H5N8 ducks and geese field samples. In six positive flocks were included this study, TS, CS wing taken...
H5N8 high-pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4B, which circulated during the 2016 epizootics in Europe, was notable for causing different clinical signs ducks and chickens. The preceding death were predominantly neurological versus respiratory To investigate determinants predominant observed ducks, we infected duck chicken primary cortical neurons. Viral replication identical neuronal cultures from both species. In addition, did not detect any major difference immune...
The passive protection afforded by the colostrum from cattle that were vaccinated prepartum with an inactivated combination vaccine against bovine respiratory syncytial virus (BRSV) was evaluated after experimental challenge of calves. Pregnant cows without or a low ELISA and neutralizing BRSV antibody titers twice not vaccinated, last immunization being at one month prior to calving. Vaccination followed rapid increase in second immunization. Twenty-eightnewborn calves fed during 6 h...
Highly pathogenic avian influenza viruses (HPAIV) emerge from low-pathogenic (LPAIV) through the introduction of basic amino acids at hemagglutinin (HA) cleavage site. Following viral evolution, newly formed HPAIV likely represents a minority variant within index host, predominantly infected with LPAIV precursor. Using reverse genetics-engineered H5N8 differing solely HA cleavage, we tested hypothesis that interaction between and majority could modulate risk emergence nature depend on host...
Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry. However, it is unclear whether play an active role viral transmission. This study aims to investigate the contribution of feather epithelium dissemination clade 2.3.4.4b goose/Guangdong/1996 lineage H5 HPAIVs environment, based on natural and experimental infections domestic mule Muscovy ducks. During 2016-2022 outbreaks, exhibited persistent marked epitheliotropism naturally...
Abstract Impaired type I interferons (IFNs) production or signaling have been associated with severe COVID-19, further promoting the evaluation of recombinant IFNs as therapeutics against SARS-CoV-2 infection. In Syrian hamster model, we show that intranasal administration IFN-α starting one day pre-infection post-infection limited weight loss and decreased viral lung titers. By contrast, at onset symptoms three days had no impact on clinical course Our results provide evidence early IFN...
The exceptional impact of the COVID-19 pandemic has stimulated an intense search for antiviral molecules. Host-targeted molecules have potential presenting broad-spectrum activity and are also considered as less likely to select resistant viruses. In this study, we investigated exerted by AM-001, a specific pharmacological inhibitor EPAC1, host exchange protein directly activated cyclic AMP (cAMP). cAMP-sensitive protein, EPAC1 regulates various physiological pathological processes but its...
ABSTRACT Highly pathogenic avian influenza viruses (HPAIV) emerge from low (LPAIV) through the introduction of basic amino acids at hemagglutinin (HA) cleavage site. Following viral evolution, newly formed HPAIV likely represents a minority variant within index host, predominantly infected with LPAIV precursor. Using reverse-genetics engineered H5N8 differing solely HA cleavage, we tested hypothesis that interaction between and majority could modulate risk emergence nature depend on host...
Abstract Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry. However, it is unclear whether play an active role viral transmission. This study aims to investigate the contribution of feather epithelium dissemination clade 2.3.4.4b goose/Guangdong/1996 lineage H5 HPAIVs environment, based on natural and experimental infections domestic ducks. During 2016-22 outbreaks, exhibited persistent marked epitheliotropism naturally infected...