A5020597759- Influenza Virus Research Studies
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Animal Disease Management and Epidemiology
- Microbial infections and disease research
- Animal Virus Infections Studies
- Respiratory viral infections research
- Xenotransplantation and immune response
- Herpesvirus Infections and Treatments
- Inflammasome and immune disorders
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Animal Diversity and Health Studies
- Livestock and Poultry Management
- vaccines and immunoinformatics approaches
- Cholesterol and Lipid Metabolism
- Virology and Viral Diseases
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
- Aquaculture disease management and microbiota
- Toxoplasma gondii Research Studies
- Physiological and biochemical adaptations
- Invertebrate Immune Response Mechanisms
- Vector-Borne Animal Diseases
École Nationale Vétérinaire de Toulouse
2020-2024
Interaction Hôtes Agents Pathogènes
2019-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Université de Toulouse
2021-2023
Infectiologie Animale et Santé Publique
2014-2018
Université de Tours
2014-2018
Centre National de la Recherche Scientifique
2014
Concurrent infections with multiple pathogens are often described in cattle respiratory illness. However, how the host-pathogen interactions influence clinical outcome has been only partially explored this species. Influenza D virus (IDV) was discovered 2011. Since then, IDV detected worldwide different hosts. A significant association between and bacterial sick shown epidemiological studies, especially Mycoplasma bovis. In an experimental challenge, aggravated M. bovis-induced pneumonia....
Bovine respiratory disease (BRD) is among the most prevalent diseases in young cattle. BRD due to complex interactions between viruses and/or bacteria, of which have a moderate individual pathogenicity.
The role of Influenza D virus (IDV) in bovine respiratory disease remains unclear. An vivo experiment resulted increased clinical signs, lesions, and pathogen replication calves co-infected with IDV Mycoplasma bovis (M. bovis), compared to single-infected calves. present study aimed elucidate the host–pathogen interactions profile kinetics lipid mediators airways these Bronchoalveolar lavage (BAL) samples collected at 2 days post-infection (dpi) were used for proteomic analyses by liquid...
Influenza D viruses (IDVs) are panzootic in multiple animal hosts, but the underlying mechanism is unclear. Through years of surveillance same order-buyer cattle facility, 32 IDV isolates were recovered from both healthy and sick animals, including those with evident antibodies against IDV. Active reassortment occurred within this facility across other areas, reassortants cocirculated animals. These shown a large extent phenotypic diversity replication efficiency pathogenesis little...
Currently circulating H5N1 influenza viruses have undergone a complex evolution since the appearance of their progenitor A/Goose/Guangdong/1/96 in 1996. After eradication that emerged Hong Kong 1997 (HK/97 viruses), new genotypes same region 2000 were more pathogenic for both chickens and mice than HK/97 viruses. These, as well virtually all highly 2000, harbour deletion aa 80-84 unstructured non-structural (NS) protein NS1 linking its RNA-binding domain to effector domain. NS segments...
Lipid mediators are known to play important roles in the onset and resolution phases of inflammatory response mammals. The phospholipid platelet activating factor (PAF) is a pro-inflammatory lipid mediator which participates vascular- innate immunity-associated processes by increasing vascular permeability, facilitating leukocyte adhesion endothelium contributing phagocyte activation. PAF exerts its function upon binding specific receptor, PAFR, abundantly expressed leukocytes endothelial...
Non-structural protein NS1 of influenza A viruses harbours several determinants pathogenicity and host-range. However it is still unclear to what extent each its two structured domains (i.e. RNA-binding domain, RBD, effector ED) contribute various activities. To evaluate the respective contributions domains, we genetically engineered variants an H7N1 low avian virus harbouring amino-acid substitutions that impair functionality either domain. The RBD- ED-mutant were compared their wt-...
ABSTRACTIt is well established that the endothelium plays a prominent role in pathogenesis of various infectious diseases mammals. However, little known about endothelial cells (EC) as targets for avian pathogens and their contribution to galliform birds. First, we explored innate immune response primary chicken aortic (pchAEC), obtained from 18-day-old embryos, stimulation with pathogen-associated molecular patterns or recombinant interferons (type I, II III IFNs). In spite abundant...