A5031088026- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Radiation Detection and Scintillator Technologies
- Dark Matter and Cosmic Phenomena
- Atomic and Subatomic Physics Research
- Particle Accelerators and Free-Electron Lasers
- Medical Imaging Techniques and Applications
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Renin-Angiotensin System Studies
- Hepatitis C virus research
- Cardiac Imaging and Diagnostics
- Electrolyte and hormonal disorders
- Superconducting Materials and Applications
- Marine Ecology and Invasive Species
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Planarian Biology and Electrostimulation
- Engineering Applied Research
- Computational Physics and Python Applications
- Cardiac electrophysiology and arrhythmias
- Marine Biology and Environmental Chemistry
Niigata University
2017-2024
Osaka University
2009-2023
Jožef Stefan Institute
2023
University of Ljubljana
2017-2023
Oita University
2019-2023
Chiba University
2000-2020
University of Yamanashi
2019
Takeda (Japan)
2019
Tokyo Metropolitan University
2018-2019
University of the Basque Country
2018
ABSTRACT Hepatitis C virus (HCV) is a causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV in circulating blood associates with lipoproteins such as very low density lipoprotein (VLDL) low-density (LDL). Although these associations suggest that are important for infectivity, the roles production infectivity not fully understood. To clarify life cycle, we analyzed effect apolipoprotein E (ApoE), component lipoprotein, on infectivity. The infectious was...
The strong regenerative capacity of planarians is considered to reside in the totipotent somatic stem cell called ‘neoblast’. However, signal systems regulating differentiation/growth/migration cells remain unclear. fibroblast growth factor (FGF)/FGF receptor (FGFR) system thought mediate various developmental events both vertebrates and invertebrates. We examined molecular structures expression DjFGFR1 DjFGFR2 , two planarian genes closely related other animal FGFR genes. proteins contain...
To survive in the iron-devoid environment of their host, pathogenic bacteria have devised multifarious cunning tactics such as evolving intricate heme transport systems to pirate extracellular heme. Yet, potential antimicrobial targets has not been explored. Herein we developed a strategy deliver antimicrobials by exploiting acquisition system protein A (HasA) Pseudomonas aeruginosa. We demonstrated that, analogous uptake, HasA can specifically traffic an antimicrobial, gallium...
Replication and infectivity of hepatitis C virus (HCV) with a defective genome is ambiguous. We molecularly cloned 38 HCV isolates genomes from 18 patient sera. The structural regions were widely deleted, the 5' untranslated, core, NS3-NS5B preserved. All deletions in frame, indicating that they are translatable to authentic terminus. Phylogenetic analyses showed self-replication independent full genomes. generated chimeric mimic isolate serum. By using this, we demonstrated for first time...
SUMMARY 1. A specific and sensitive radioimmunoassay has been developed used to measure circulating atrial natriuretic peptide (ANP) in normal man patients with chronic renal failure. 2. Circulating ANP levels rose head‐down tilt exercise, were raised failure proportion volume status. This suggests that release is mediated via increased stretch, although other mechanisms cannot be excluded. 3. Extracts of human plasma subjected reverse phase HPLC showed one major peak immunoreactivity...
To compare the effects of deep learning reconstruction (DLR) on respiratory-triggered T2-weighted MRI liver between single-shot fast spin-echo (SSFSE) and (FSE) sequences.
A 60-year-old woman suffering from heart failure was found to have Crow-Fukase syndrome. precise cardiovascular study revealed the existence of pulmonary hypertension (PH), cardiomegaly and myocardial hypertrophy in addition manifestations this syndrome such as hyperpigmentation, hypertrichosis, finger clubbing, polyneuropathy, organomegaly plasma cell dyscrasia. These findings suggest possibility that patients with cardiopulmonary disorders including PH which might cause some symptoms...
The selective β1 adrenoceptor agonist denopamine was studied for its effectiveness in abolishing active vasospastic angina 10 patients without obstructive coronary artery stenosis. All had anginal attacks at least once a day during the 3-day placebo period. Denopamine, 40 mg/day, completely abolished 7 (efficacy 70%). Denopamine reduced mean daily number of and nitroglycerin consumption comparison with (0.56±1.23 vs 2.20±1.27; p<0.005 0.10±0.24 1.60±1.93; p<0.05, respectively). Aggravation...
To evaluate the image quality and lesion detectability of pancreatic phase thin-slice computed tomography (CT) images reconstructed with a deep learning-based reconstruction (DLR) algorithm compared filtered-back projection (FBP) hybrid iterative (IR) algorithms.Fifty-three patients who underwent dynamic contrast-enhanced CT including were enrolled in this retrospective study. Pancreatic (0.625 mm) each FBP, IR, DLR. Objective signal-to-noise ratio parenchyma, contrast-to-noise lesions...
We report a case of primary aldosteronism in 30-year-old woman without hypertension or any other characteristic symptoms. The condition was first suspected by hypokalemia (2.6 mEq/liter), which incidentally found routine checkup. There evidence suppressed plasma renin activity (PRA) and elevated aldosterone levels. However, the blood pressure never reached hypertensive level, circulating volume within normal range. A functioning right adrenal tumor diagnosed scintigraphy, computerized x-ray...
1. This study was designed to investigate the effects of intracerebroventricular or intravenous atrial natriuretic peptide (ANP) on plasma arginine-vasopressin (AVP) levels, renin activity (PRA), blood pressure (BP) and heart rate (HR) in conscious rats. 2. No changes were observed AVP levels PRA after injection ANP (0.3 nmol/kg). Also no found BP HR dose range 0.01–0.3 nmol/ kg. 3. significant administration at 2.5 nmol/kg hydrated rats 0.1 dehydrated rats, although larger sufficient cause...