A5102793061- Diabetes Management and Research
- Gestational Diabetes Research and Management
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Breastfeeding Practices and Influences
- Maritime Navigation and Safety
- Maternal Mental Health During Pregnancy and Postpartum
- Regulation of Appetite and Obesity
- Cardiovascular Issues in Pregnancy
- Age of Information Optimization
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Public Health and Nutrition
- Biochemical Analysis and Sensing Techniques
- Health Literacy and Information Accessibility
- Medication Adherence and Compliance
- Pregnancy-related medical research
- Dark Matter and Cosmic Phenomena
Steno Diabetes Centers
2020-2025
Novo Nordisk (Denmark)
2025
Novo Nordisk (United Kingdom)
2025
University of Southern Denmark
2024
Rigshospitalet
2010-2019
Gentofte Hospital
2018
University of Copenhagen
2011-2017
OBJECTIVE To assess whether intermittent real-time continuous glucose monitoring (CGM) improves glycemic control and pregnancy outcome in unselected women with pregestational diabetes. RESEARCH DESIGN AND METHODS A total of 123 type 1 diabetes 31 2 were randomized to use CGM for 6 days at 8, 12, 21, 27, 33 weeks addition routine care, including self-monitored plasma seven times daily, or care only. optimize control, readings evaluated by a caregiver. HbA1c, glucose, severe hypoglycemia,...
OBJECTIVE Continuous glucose monitoring (CGM) is increasingly used to assess control in diabetes. The objective was examine how analysis of data might improve our understanding the role temporal variation has on large-for-gestational-age (LGA) infants born women with RESEARCH DESIGN AND METHODS Functional (FDA) applied 1.68 million measurements from 759 measurement episodes, obtained two previously published randomized controlled trials CGM pregnant A total 117 type 1 diabetes (n = 89) and 2...
OBJECTIVE We evaluate the association between gestational weight gain and offspring birth in singleton term pregnancies of women with type 1 diabetes. RESEARCH DESIGN AND METHODS One hundred fifteen consecutive referred at <14 weeks were retrospectively classified as underweight (prepregnancy BMI <18.5 kg/m2; n = 1), normal (18.5–24.9; 65), overweight (25.0–29.9; 39), or obese (≥30.0; 10). Gestational was categorized excessive, appropriate, insufficient according to Institute...
This study aimed to examine the relationship between average glucose levels, assessed by continuous monitoring (CGM), and HbA1c levels in pregnant women with diabetes determine whether calculations of standard estimated (eAG) from measurements are applicable diabetes. CGM data 117 (89 type 1 diabetes; 28 2 diabetes) were analysed. Average calculated 5–7 day profiles (mean 1275 values per profile) paired a corresponding (±1 week) measure. In total, 688 glucose–HbA1c pairs obtained across...
Abstract Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying proteins (RAMPs), mediate suppression of food intake and body weight. To understand molecular neural mechanisms cagrilintide action, we used single-nucleus RNA sequencing to define 89 cell populations across rat, mouse, non-human primate...
GLP-1 receptor agonists (GLP1RAs) effectively reduce feeding to treat obesity, although nausea and other aversive side effects of these drugs can limit their use. Brainstem circuits that promote satiation mediate the physiologic control body weight be distinguished from those cause aversion. It remains unclear whether brainstem Glp1r neurons contribute normal regulation energy balance GLP1RAs appetite via distinct responses, however. Hence, we defined roles for AP NTS -expressing (AP...
How well new technology is applied to the daily management of type 1 diabetes (T1D) may be highly influenced by personality traits. The number studies examining how traits influence self-management technologies such as continuous glucose monitoring and carbohydrate counting with automated insulin bolus calculation based on ratios sensitivity scarce. Derived from a randomized controlled trial, we aimed examine association between glycemic patient-reported outcomes in adults T1D multiple...
To explore insulin pump settings in a cohort of pregnant women with type 1 diabetes on therapy bolus calculator.Twenty-seven were included this study. At 8, 12, 21, 27 and 33 weeks, HbA1c recorded. Results compared 96 multiple daily injection therapy.Throughout pregnancy, the carbohydrate-to-insulin ratio decreased at all three main meals. The most pronounced decrease was observed breakfast, where reduced, from median 12 (range 4-20) early pregnancy to 3 (2-10) g carbohydrate per unit late...
Abstract Aims To explore whether real‐time continuous glucose monitoring during labour and delivery supplementary to hourly self‐monitored plasma in women with Type 1 diabetes reduces the prevalence of neonatal hypoglycaemia. Methods Women participating a randomized controlled trial on effect pregnancy were included this study. Twenty‐seven 60 (45%) intervention arm used delivery, glucose. Real‐time data covering last 8 h prior retrospectively evaluated, maternal hypo‐ hyperglycaemia defined...
Diabet. Med. 29, 272–277 (2012) Abstract Aim To evaluate self‐reported satisfaction and barriers to initiating real‐time continuous glucose monitoring in early pregnancy among women with pregestational diabetes. Methods Fifty‐four Type 1 diabetes 14 2 were offered for 6 days at median 9 (range 6–14) gestational weeks asked answer a semi‐structured questionnaire on patient satisfaction. Results Median HbA 1c was 49 34–86) mmol/mol) [6.6 (5.3–10.0) %] duration of 12 (0.5–37) years. Continuous...
What's new? Among 12 women at estimated high risk of severe hypoglycaemia in pregnancy using real‐time continuous glucose monitoring from early onwards, the incidence rates were 2.8 events/patient‐year year before pregnancy, and 17.5 0.3 after initiation pregnancy. Further evaluation is required as to whether mid‐pregnancy highly selected with Type 1 diabetes may help reduce hypoglycaemia. Other elements focused intervention against a routine care setting probably also contribute reduction.
The aim of this study was to explore changes in health-related quality life, anxiety and depression symptoms during pregnancy women with pregestational diabetes.An observational cohort including 137 pregnant diabetes (110 type 1 27 2). To evaluate from early late pregnancy, the internationally validated questionnaires 36-Item Short-Form Health Survey (SF-36) Hospital Anxiety Depression Scale (HADS) were completed at 8 33 gestational weeks.From SF-36 scales Physical Function, Role Physical,...
Shoulder dystocia is a rare but severe complication of vaginal delivery and diabetic women are at high risk. The aim this study was to identify fetal sonographic maternal glycemic characteristics associated with shoulder in pregnant type 1 diabetes.Twelve cases (5%) among 241 consecutive deliveries diabetes followed Rigshospitalet University Hospital 2009-2013 were retrospectively identified local database. Fetal clinical data compared 69 uncomplicated deliveries.Women experiencing had...
Abstract Aim To explore the role of early pregnancy health‐related quality life, anxiety, depression and locus control for outcome in women with pregestational diabetes. Methods This was a cohort study 148 pregnant diabetes (118 Type 1 30 2 diabetes), who completed three internationally validated questionnaires: 36‐item Short‐Form Health Survey, Hospital Anxiety Depression Scale Multidimensional Locus Control survey at 8 weeks. Selected outcomes were preterm delivery (< 37 weeks) large...
The aim of this study was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women type 1 diabetes.An observational 198 pregnant diabetes. 25-Hydroxy-Vitamin HbA1c were measured blood samples early (median 8 weeks, range 5-14) late (34 32-36) pregnancy. Kidney involvement (microalbuminuria or nephropathy) at inclusion, smoking status (<37 weeks) (blood pressure ≥140/90 mmHg proteinuria) registered. Vitamin supplementation 10 μg daily routinely...
We describe the feasibility of continuous glucose monitoring (CGM)-enabled insulin-pump therapy during pregnancy in a woman with type 1 diabetes, who was treated CGM-enabled her third pregnancy. During first pregnancy, multiple daily injections and baseline HbA1c 8.9%. Due to pre-eclampsia, child born preterm, had neonatal hypoglycemia. In planning second initiated, resulting an 6.8% early but without morbidity. Before introduced, 6.4% The patient satisfied this therapy, pre-eclampsia did...
Introduction There are beneficial effects of advanced carbohydrate counting with an automatic bolus calculator (ABC) and intermittently scanned continuous glucose monitoring (isCGM) in persons type 1 diabetes. We aim to compare the isCGM, training ABC combination two concepts standard care. Methods analysis A multi-centre randomised controlled trial inclusion criteria: ≥18 years, diabetes ≥1 year, injection therapy, HbA1c >53 mmol/mol, whereas daily use and/or CGM/isCGM wear exclusion...