A5071429060- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Neurogenesis and neuroplasticity mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Multiple Sclerosis Research Studies
- Dermatology and Skin Diseases
- Bacterial Infections and Vaccines
- Rhetoric and Communication Studies
- Discourse Analysis in Language Studies
- RNA Research and Splicing
- Escherichia coli research studies
- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Viral Infectious Diseases and Gene Expression in Insects
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
- Immune responses and vaccinations
Inserm
2002-2024
Université Paris Cité
2017-2024
Institut Necker Enfants Malades
2021-2024
Centre National de la Recherche Scientifique
2014-2024
Sorbonne Université
2014-2017
Institut du Cerveau
2013-2017
Thomas Jefferson University
2007-2014
Pitié-Salpêtrière Hospital
2014
Institut Curie
2013
Institut Gustave Roussy
2002
Abstract IL-17-producing CD8+ T cells (Tc17) appear to play a role in range of conditions, such as autoimmunity and cancer. Thus far, Tc17 have been only marginally studied, resulting paucity data on their biology function. We demonstrate that Th17 share similar developmental characteristics, including the previously unknown promoting effect IL-21 cell differentiation IL-23-dependent expression IL-22. Both STAT1 STAT4 are required for optimal development maximal secretion cytokines....
Abstract IL-27 counters the effect of TGF-β+IL-6 on naive CD4+ T cells, resulting in near complete inhibition de novo Th17 development. In contrast, little is known about already differentiated cells. A better understanding how regulates these cells needed to evaluate therapeutic potential cells-associated diseases. this study, we show that had surprisingly committed despite its expression a functional IL-27R. Contrary differentiation did not suppress retinoid-related orphan receptor (ROR)γt...
Numerous studies have demonstrated the role of immune cells, in particular macrophages, central nervous system (CNS) pathologies. There are two main macrophage populations CNS: (i) microglia, which resident macrophages CNS and derived from yolk sac progenitors during embryogenesis, (ii) monocyte-derived (MDM), can infiltrate disease bone marrow progenitors. The roles each subpopulation differ depending on pathology being studied. Furthermore, there is no consensus histological markers or...
One major challenge in multiple sclerosis is to understand the cellular and molecular mechanisms leading disease severity progression. The recently demonstrated correlation between remyelination emphasizes importance of identifying factors a favourable outcome. Why fails or succeeds patients remains largely unknown, mainly because has never been studied within humanized pathological context that would recapitulate events plaque formation such as infiltration inflammatory cells. Therefore, we...
Numerous studies have demonstrated the role of immune cells, in particular macrophages, central nervous system (CNS) pathologies. There are two main macrophage populations CNS: (i) microglia, which resident macrophages CNS and derived from yolk sac progenitors during embryogenesis, (ii) monocyte-derived (MDM), can infiltrate disease bone marrow progenitors. The roles each subpopulation differ depending on pathology being studied. Furthermore, there is no consensus histological markers or...
Abstract We have previously shown that mice lacking the IL-12-specific receptor subunit β2 (IL-12Rβ2) develop more severe experimental autoimmune encephalomyelitis than wild-type (WT) mice. The mechanism underlying this phenomenon is not known; nor it known whether deficiency of IL-12Rβ2 impacts other disorders similarly. In present study we demonstrate IL-12Rβ2−/− earlier onset and disease in streptozotocin-induced model diabetes, indicating predisposition IL-12Rβ2-deficient to diseases. T...
The signals controlling marginal zone (MZ) and follicular (FO) B cell development remain incompletely understood. Here, we show that AKT orchestrates MZ formation in mice humans. Genetic models increase signaling cells or abolish its impact on FoxO transcription factors highlight the AKT-FoxO axis as an on-off switch for mice. In humans, splenic immunoglobulin (Ig) D+CD27+ cells, proposed equivalent, display higher than naive IgD+CD27- memory IgD-CD27+ develop AKT-dependent manner from their...
Neisseria meningitidis (the meningococcus) remains a major cause of bacterial meningitis and fatal sepsis. This commensal bacterium the human nasopharynx can invasive diseases when it leaves its niche reaches bloodstream. Blood-borne meningococci have ability to adhere endothelial cells rapidly colonize microvessels. crucial step enables dissemination into tissues promotes deregulated inflammation coagulation, leading extensive necrotic purpura in most severe cases. Adhesion blood vessels...
IL-17-secreting CD8(+) T cells (Tc17 cells) have been implicated in immunity to infections, cancer, and autoimmune diseases. Thus far, studies on Tc17 primarily investigated their development from naïve precursors, while the biology of committed has less characterized, particular during effector phase immune responses. IL-27 is an important regulator inflammation through induction regulatory Tr1 cells, as well a suppressor Th17-cell development. suppresses but its effects are unknown. Here...
CD4+ FOXP3+ Tregs are currently explored to develop cell therapies against immune-mediated disorders, with an increasing focus on antigen receptor-engineered Tregs. Deciphering their mode of action is necessary identify the strengths and limits this approach. Here, we addressed issue in autoimmune disease CNS, EAE. Following induction, autoreactive upregulated LAG-3 CTLA-4 LNs, while IL-10 amphiregulin (AREG) were increased CNS Using genetic approaches, demonstrated that IL-10, CTLA-4,...
The development of the human immune system lasts for several years after birth. impact this maturation phase on quality adaptive immunity and acquisition immunological memory infection at a young age remains incompletely defined. Here, using an antigen-reactive T cell (ARTE) assay multidimensional flow cytometry, we profiled circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-reactive CD3