A5103252392- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Toxin Mechanisms and Immunotoxins
- Silymarin and Mushroom Poisoning
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Coordination Chemistry and Organometallics
- Organometallic Complex Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Pancreatic and Hepatic Oncology Research
- Advanced Thermodynamics and Statistical Mechanics
- Multiple Myeloma Research and Treatments
- Tryptophan and brain disorders
- Advanced Breast Cancer Therapies
- stochastic dynamics and bifurcation
- Cancer Genomics and Diagnostics
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Synthesis and Catalytic Reactions
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Synthesis and Biological Evaluation
- Neuroendocrine Tumor Research Advances
University Hospital of Basel
2023
Heidelberg Pharma (Germany)
2009-2021
University of Zurich
2013-2018
University Hospital of Zurich
2016
Regensburg University of Applied Sciences
2014
University of Stuttgart
2004-2007
University of Konstanz
2004
Roche (Switzerland)
2000-2002
Philipps University of Marburg
1996-1999
Phillips University
1996
Abstract Mesenchymal stem cells (MSC) display unique suppressive properties on T-cell immunity, thus representing an attractive vehicle for the treatment of conditions associated with harmful responses such as organ-specific autoimmunity and graft-versus-host disease. Toll-like receptors (TLR) are primarily expressed antigen-presenting recognize conserved pathogen-derived components. Ligation TLR activates multiple innate adaptive immune response pathways to eliminate protect against...
Indoleamine-2,3-dioxygenase (IDO) inhibitors have entered clinical trials based on their ability to restore anti-tumor immunity in preclinical studies. However, the mechanisms leading constitutive expression of IDO human tumors are largely unknown. Here we analyzed pathways mediating cancer. IDO-positive tumor cells and tissues showed basal phosphorylation acetylation STAT3 as evidenced by western blotting immunoprecipitation. Inhibition IL-6 or using siRNA and/or pharmacological reduced...
The Einstein relation connecting the diffusion constant and mobility is violated beyond linear response regime. For a colloidal particle driven along periodic potential imposed by laser traps, we test recent theoretical generalization of to nonequilibrium regime which involves an integral over measurable velocity correlation functions.
1-methyl-D-tryptophan (1-D-MT) is currently being used in clinical trials patients with relapsed or refractory solid tumors the aim of inhibiting indoleamine-2,3-dioxygenase (IDO)-mediated tumor immune escape. IDO expressed and tumor-draining lymph nodes degrades tryptophan (trp) to create an immunsuppressive micromilieu both by depleting trp accumulating immunosuppressive metabolites kynurenine (kyn) pathway. Here we show that proliferation alloreactive T-cells cocultured IDO1-positive...
Despite major treatment advances in recent years, patients with multiple myeloma inevitably relapse. The RNA polymerase II complex has been identified as a promising therapeutic target both proliferating and dormant cancer cells. Alpha-amanitin, toxin so far without clinical application due to high liver toxicity, specifically inhibits this complex. Here, we describe the development of HDP-101, an anti-B-cell maturation antigen (BCMA) antibody conjugated amanitin derivative. HDP-101...
Better synthetic efficiency is achieved in 1,4-additions NMP:THF mixtures and enantioselective additions to aldehydes (see below) when the diorganozinc compounds R(TMSM)Zn are used instead of R2Zn (NMP = N-methylpyrrolidone, TMSM Me3SiCH2, R alkyl, aryl). With these new reagents, which have been characterized by NMR spectroscopy, no group “wasted”. The behaves as a nontransferable ligand.
ADVERTISEMENT RETURN TO ISSUEPREVNoteHighly Enantioselective Addition of Mixed Diorganozincs to Aldehydes†Christian Lutz and Paul KnochelView Author Information Fachbereich Chemie der Philipps-Universität Marburg, Hans-Meerwein-Strasse, D-35032 Germany Cite this: J. Org. Chem. 1997, 62, 22, 7895–7898Publication Date (Web):October 31, 1997Publication History Received11 August 1997Published online31 October inissue 1...
Fibrosis as a common problem in patients with Crohn's disease is result of an imbalance toward excessive tissue repair. At present, there no specific treatment option. Pirfenidone approved for the idiopathic pulmonary fibrosis both antifibrotic and anti-inflammatory effects. We subsequently investigated impact pirfenidone on development new mouse model intestinal fibrosis. Small bowel resections from donor mice were transplanted subcutaneously into neck recipients. Animals received either...
α-Amanitin and related amatoxins have been studied for more than six decades mostly by isolation from death cap mushrooms. The total synthesis, however, remained challenging due to unique structural features. is a potent inhibitor of RNA polymerase II. Interrupting the basic transcription processes eukaryotes leads apoptosis cell. This mechanism makes toxin an ideal payload antibody-drug conjugates (ADCs). Only microgram quantities toxins, when delivered selectively tumor sites through...
We experimentally and theoretically investigate the collective behavior of three colloidal particles that are driven by a constant force along toroidal trap. Due to hydrodynamic interactions, characteristic limit cycle is observed. When we additionally apply periodic sawtooth potential, find novel caterpillar-like motional sequence dominated interactions promotes surmounting potential barriers particles.
Due to their immunosuppressive properties, human mesenchymal stem cells (hMSC) represent a promising tool for cell-based therapies of autoimmune diseases such as multiple sclerosis (MS). Mouse MSC (mMSC) have been used extensively characterize and optimize route administration, motility, cellular targets, mechanisms in mouse models diseases, experimental encephalomyelitis (EAE). Tryptophan (trp) catabolism by indolamine-2,3-dioxygenase 1 (IDO1) is chief endogenous metabolic pathway that...
Idiosyncratic drug-induced liver injury (DILI) is a rare, unpredictable hepatic adverse event and the most common cause of acute failure in Europe US. Ribociclib potent Cyclin-dependent kinase 4 6 (CDK4/6)-inhibitor administered for advanced hormone-receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. Previous reports have shown hepatotoxicity without necrosis related to ribociclib.A 41-year-old female patient with primary metastatic HR-positive,...
Single-file diffusion (SFD), prevalent in many chemical and biological processes, refers to the one-dimensional motion of interacting particles pores which are so narrow that mutual passage is excluded. Since sequence such a situation remains unaffected over time t, this leads strong deviations from normal diffusion, e.g. an increase particle mean-square-displacement as square root t. We present experimental results diffusive behaviour colloidal channels with varying density. The realized by...
Intestinal fibrosis is thought to be a consequence of excessive tissue repair, and constitutes common problem in patients with Crohn's disease (CD). While seems require inflammation as prerequisite it unclear whether the severity or persistence influences degree fibrosis. Our aim was investigate role sustained fibrogenesis. For initiation vivo models Il10-/- spontaneous colitis, dextran sodium sulfate (DSS)-induced chronic colitis heterotopic transplantation were used. In mice, we determined...
Synthetic methods on the macrocyclization of peptides are high interest since they facilitate synthesis various types potentially bioactive compounds, e.g. addressing targets like protein–protein-interactions. Herein, we report an efficient method to construct tryptathionine-cross-links in between amino acids Trp and Cys. This reaction not only is basis for total death cap toxin α-amanitin but also provides rapid access new amanitin analogues. study first time presents a systematic...
Eine bessere Ökonomie wird bei 1,4‐Additionen in NMP:THF‐Mischungen und enantioselektiver Addition an Aldehyde (siehe unten) erzielt, wenn die Diorganozinkverbindungen R(TMSM)Zn statt R 2 Zn verwendet werden (NMP = N ‐Methylpyrrolidon, TMSM Me 3 SiCH , Alkyl, Aryl), da so keine Reste „verschwendet”︁ werden. Diese neuen Diorganozinkreagentien wurden NMR‐spektroskopisch Lösung charakterisiert. Die TMSM‐Gruppe verhält sich als nicht übertragbarer Ligand. magnified image
Neopentyl and Neophyl groups have been found to be excellent nontransferable for organozinc organocopper chemistry. We shown that mixed diorganozincs of the type FG-R-Zn(CH2CMe2R) can used advantageously enantioselective addition aldehydes. These copper or zinc reagents are also very efficient in Michael various activated alkenes.
e14527 Background: Currently, numerous antibody-drug conjugates (ADCs) are evaluated for hematologic malignancies with toxic payloads mainly affecting only proliferating cells, and thus resulting in limited efficacy diseases low proliferation. We focus on amanitin based ADCs (ATACs: antibody-targeted Amanitin conjugates) targeting BCMA (B Cell Maturation Antigen; CD269). binds to RNA pol II thereby inhibits the cellular transcription process at very concentrations independent of cell is...