A5044330800- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Vitamin D Research Studies
- Glaucoma and retinal disorders
- Cardiac Ischemia and Reperfusion
- Birth, Development, and Health
- Hydrogen's biological and therapeutic effects
- Gestational Diabetes Research and Management
- Sulfur Compounds in Biology
- Paraoxonase enzyme and polymorphisms
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Retinal Diseases and Treatments
- Apelin-related biomedical research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hemoglobinopathies and Related Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Biochemical effects in animals
- Pancreatitis Pathology and Treatment
- Medicinal Plants and Neuroprotection
- Folate and B Vitamins Research
- Air Quality and Health Impacts
- Ion channel regulation and function
- Amoebic Infections and Treatments
Kocaeli Üniversitesi
2014-2025
Gazi University
2013
Istanbul Medipol University
2013
Background: High levels of homocysteine and oxidative stress are known to be associated with premature vascular disease in type 2 diabetes mellitus (DM). The aim this study was estimate oxidant-antioxidant status determine the relationship between them diabetic patients without microalbuminuria. Methods: Fasting blood samples were obtained from 48 (17 31 microalbuminuria) 20 healthy subjects. Serum total (tHcy), plasma malondialdehyde (MDA) erythrocyte glutathione (GSH) peroxidase (GPx)...
This study investigated the protective effects of carvedilol, a potent antioxidant, in rat model tourniquet-induced ischaemia-reperfusion injury hind limb. Thirty rats were divided equally into three groups: control group (group 1) was only anaesthetized, without creating an injury; 2 submitted to ischaemia (4 h), followed by 2-h reperfusion period; and 3 pre-treated with carvedilol (2 mg/kg per day) for 10 days prior ischaemia-reperfusion. Ischaemia-reperfusion produced significant decrease...
<i>Objective:</i> Cisplatin (DDP, <i>cis</i>-diamminedichloroplatinium II) is one of the most potent chemotherapeutic antitumor drugs, but able to generate reactive oxygen species (ROS) and it also inhibits activity antioxidant enzymes in renal tissue. In present study, we investigated preventive effect 100, 200 400 mg/kg b.w. doses vitamin E (VE), 25, 50, 100 A (VA) combination on malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH) levels superoxide dismutase...
<i>Background/Aims:</i> Cytokine secretion is known to play an important role in the pathophysiology of depression, and levels proinflammatory cytokines are increased chronic renal failure (CRF) patients. The objective this study was examine correlation between CRF patients degree depression. <i>Methods:</i> 31 on hemodialysis, continuous ambulatory peritoneal dialysis, conservatively managed kidney disease (CKD) were enrolled study. Depressive symptoms measured with...
Objective: The oxidant–antioxidant balance plays an important role in the pathogenesis of COPD. aim present study was to evaluate effects exercise, as oxidative stress factor on and investigate whether short‐term antioxidant treatment affects lipid peroxidation products. Methodology: Twenty‐one stable COPD patients 10 control subjects were included study. Symptom‐limited exercise tests performed by all subjects. Blood collected before 1 h after before, 3 patients, for analysis...
Background: Depression is one of the most commonly encountered psychiatric problems in peritoneal dialysis (PD) patients. Our aim was to investigate associations between oxidative and nitrosative stress (O&NS) brain-derived neurotrophic factor (BDNF) PD patients with elevated depressive symptoms (EDS). Methods: Eighty-three 84 healthy controls were enrolled this study. In patients, two subgroups formed: 28 55 without EDS. EDS defined as a Beck Inventory (BDI) score ≥17 Serum malondialdehyde...
Reperfusion injury is a consequence of inadequate energy supply and acidosis in ischemic tissues chain events triggered by oxygen-derived free radicals released response to exposure oxygen. In this study, we aimed assess the effects clopidogrel, an antithrombotic agent, on experimental ischemia-reperfusion model rats. The ischemia was performed blockade circulation right lower extremity at trochanter major level for 6 hours. Then, reperfused 4 Another group rats pretreated with clopidogrel...
Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, which may increase content reactive oxygen and nitrogen species. The objective this study was to investigate effects Neuropeptide Y on oxidative nitrosative balance brain-derived neurotrophic factor levels induced pentylenetetrazole (a standard convulsant drug) in hippocampus Wistar rats. Three groups seven rats were treated intraperitoneally as follows: group 1 (saline + saline) ml saline, 2...
This study aimed to investigate the effects of VNS in transient middle cerebral artery occlusion and reperfusion (MCAO/R) rat model ischemia based on behavioral, morphological, molecular approaches.Wistar albino rats were divided into 3 groups: ischemia-reperfusion (I/R), I/R+VNS, sham (for I/R). Each group was further two subgroups for assessment neurological deficits infarct area, or biochemical parameters related oxidative stress.The area scores significantly lower I/R+VNS compared with...
Keywords: apoptosis; arbutus unedo L; formaldehyde; hippocampus; oxidative stress
<i>Background:</i> Excessive generation of reactive oxygen species (ROS) contributes to the process progressive renal injury in a variety clinical and experimental diseases. The present study was designed test hypothesis that treatment with vitamins decreases chronic failure (CRF). <i>Methods:</i> Forty male Sprague-Dawley rats were divided into 5 groups: group 1, control; 2, 5/6 nephrectomy (CRF); other groups injected (E, A, D). After 8 weeks, urea, creatinine...
It is still not completely clear whether carbamazepine causes alterations in vitamin D status and bone metabolism. The objective of this study was to investigate the effects on serum levels 25-hydroxyvitamin biomarkers formation resorption healthy rats. Levels calcium, D, parathormone, C-telopeptide, specific alkaline phosphatase osteocalcin were measured 3 groups rats consisting controls (n=10), isotonic saline solution group (n=10) (n=10). Mean calcium found be significantly lower...
The aim of the study was to investigate association paraoxonase 1 (PON1) polymorphism, PON1/arylesterase (ARE) activity and oxidative stress index (OSI) in breast cancer (BC) patients with type 2 diabetes (DM).Our group consisted 30 healthy women (HV group) 66 female BC patients. were divided into two groups: those (n=37) without DM (n=29) (BDM NBDM group). Genotyping PON1 Q192R L55M polymorphisms done by polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP)...