A5015683044- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Tumors and Oncological Cases
- Thyroid Cancer Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Bone Tumor Diagnosis and Treatments
- Cancer and Skin Lesions
- Oral Health Pathology and Treatment
- Cellular Mechanics and Interactions
- Neuroblastoma Research and Treatments
- Sinusitis and nasal conditions
- Salivary Gland Disorders and Functions
- Galectins and Cancer Biology
- Colorectal Cancer Screening and Detection
- Ear Surgery and Otitis Media
- Infectious Diseases and Mycology
- Peptidase Inhibition and Analysis
- Tendon Structure and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroendocrine Tumor Research Advances
- Biomarkers in Disease Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Dental Protein Studies
University of Michigan
2020-2024
October University of Modern Sciences and Arts
2024
Alexandria University
2024
University of Colorado Denver
2013-2016
King's College London
2016
Denver Health Medical Center
2013-2016
King's College Hospital
2016
Cairo University
2013
University of Colorado Health
2004
Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues affect myofibroblast differentiation in 3D poorly understood. Here, we describe a multicomponent hydrogel that recapitulates structure of interstitial regions where idiopathic pulmonary fibrosis (IPF) initiates. In contrast to findings on 2D hydrogels, was inversely...
Cells sense the extracellular environment and mechanical stimuli translate these signals into intracellular responses through mechanotransduction, which alters cell maintenance, proliferation, differentiation. Here we use a mouse model of trauma-induced heterotopic ossification (HO) to examine how cell-extrinsic forces impact mesenchymal progenitor (MPC) fate. After injury, single-cell (sc) RNA sequencing injury site reveals an early increase in MPC genes associated with pathways adhesion...
A 48-year-old female underwent routine mammographic screening, which revealed an irregular, high-density spiculated lesion in the right breast. Further imaging and core biopsy confirmed invasive ductal carcinoma (IDC), Grade 3, ER/PR-positive, HER2-negative, with axillary lymph node metastasis. The patient surgical intervention, subsequent PET/CT localized disease without distant This case underscores importance of screening asymptomatic individuals.
Imaging plays a critical role in changing the treatment approach for accidentally discovered gallbladder carcinoma (GBC), particularly determining extent of disease and staging guiding surgical therapeutic decisions. 1 A 62-year-old female patient initially presented with constipation. An abdominal ultrasound scan reveals an incidental large, lobulated mass gallbladder. Further imaging triphasic CT MRCP was recommended to confirm diagnosis evaluate spread. Follow-up scans were performed...
Cystic dysplasia of the testis is a rare congenital anomaly. It presents diagnostic. Challenge to physician and should be distinguished from malignant lesions. We herewith present 29-year-old man who presented with right scrotal swelling history renal agenesis. Detailed investigations, including ultrasound magnetic resonance imaging, helped establish diagnosis cystic dysplasia. To best our knowledge, case one first cases Rete in literature, which as associated anomalies.
In this retrospective histologic study, galectin-3 had a sensitivity of 92% (22/24) for papillary thyroid carcinoma and 44% (4/9) follicular carcinoma. Thyroid peroxidase (TPO) 50% (12/24) 11% (1/11) The combination TPO 96% (23/24)
Synthetic hydrogels represent an exciting avenue in the field of regenerative biomaterials given their injectability, orthogonally tunable mechanical properties, and potential for modular inclusion cellular cues. Separately, recent advances soluble factor release technology have facilitated control over milieu cell microenvironments via microparticles. A composite hydrogel incorporating both these components can robustly mediate tendon healing following a single injection. Here, synthetic...
Effective tendon regeneration following injury is contingent on appropriate differentiation of recruited cells and deposition mature, aligned, collagenous extracellular matrix that can withstand the extreme mechanical demands placed tissue. As such, myriad biomaterial approaches have been explored to provide biochemical physical cues encourage tenogenesis template aligned in lieu dysfunctional scar tissue formation. Fiber-reinforced hydrogels present an ideal system toward this end given...
Endoscopic ultrasound with fine needle aspiration (EUS-FNA) has become the standard of care in evaluation solid pancreatic lesions. Limited data exist on interobserver agreement (IOA) among cytopathologists assessing EUS-FNA specimens. This study aimed to evaluate IOA cytology specimens lesions using a novel standardized scoring system and assess individual clinical cytologic predictors IOA.Consecutive patients who underwent at tertiary referral center were included. slides evaluated by four...
In spite of the recent discovery genetic mutations in most myelodysplasic (MDS) patients, pathophysiology these disorders still remains poorly understood, and only few vivo models are available to help unravel disease. We performed global specific gene expression profiling functional pathway analysis purified Sca1+ cells two MDS transgenic mouse that mimic human high-risk (HR-MDS) acute myeloid leukemia (AML) post MDS, with NRASD12 BCL2 transgenes under control different promoters...
In this retrospective histologic study, galectin-3 had a sensitivity of 92% (22/24) for papillary thyroid carcinoma and 44% (4/9) follicular carcinoma. Thyroid peroxidase (TPO) 50% (12/24) 11% (1/11) The combination TPO 96% (23/24) From prognostic standpoint, patients whose carcinomas expressed both markers, all became free disease. Of those but not TPO, 57% (4/7) disease, 29% (2/7) persistent 14% (1/7) progressive This study confirms previous observations that alone is highly sensitive...
Background Pyoderma gangrenosum (PG) is a skin condition characterized by necrotic ulcers and most commonly occurs on the legs in association with inflammatory bowel disease rheumatoid arthritis; however, PG rarely involves head neck, very causes nasal septal perforation. Objective Here, we describe case report of causing perforation 71-year-old male truncal lesions absence either or autoimmune arthritis. Methods Case histologic description. Results Histology from mucosal biopsies showed...
Background: incidence of Colorectal cancer (CRC) is increasing globally. In Egypt, CRC ranks the sixth most common in males and fifth females. Aim: To assess expression estrogen receptors (alpha beta) pre-malignant (adenomatous polyps IBD), malignant colorectal lesions normal colonic mucosa group Egyptian patients. Methods: This prospective study was done on 45 patients presenting with symptoms, were divided into four groups; 15 patients, 10 adenomatous polyps, IBD control group. Patients...
Patients with colorectal cancer (CRC) have a higher chance of survival when the disease is detected and treated effectively at an early stage. Plasmacytoma variant translocation 1 (PVT-1), oncogenic lncRNA, neuroblastoma associated trans-cript (NBAT1), tumor suppressor been linked to CRC progression, acting as competing endo-genous RNAs miRNA-145 oncomiRNA-21. The aim current study was construct endogenous RNA (ceRNA) CRC. In addition, we aimed investigate impact single nucleotide...