Anaplastic thyroid cancer (ATC) is one of the most lethal and aggressive human malignancies, with no effective treatment currently available. The Hippo tumor suppressor pathway highly conserved in mammals plays an important role carcinogenesis. TAZ major key effectors pathway. However, mechanism supporting abnormal expression ATC remains to be characterized. In present study, we identified USP26, a DUB enzyme ubiquitin-specific proteases family, as bona fide deubiquitylase ATC. USP26 was...

Vertical jumping is one of the basic motor skills, and it an essential part many sports. The main purpose this paper to investigate characteristics vertical children. This uses a motion capture system, three-dimensional platforms, simulation modeling system analyze kinematics dynamics performance children's jumping. compression time increases from 3 4 years old, flight height with age stage gradually. In phase pushing phase, hip knee joint play major role; in landing ankle role. Muscle...

Prostate cancer is a common malignancy in urology which often develops into castration-resistant prostate (CRPC) after hormone therapy. Studies have shown that the mechanism of its occurrence related to androgen receptor splice variants (AR variants). This work employs bibliometric approach explore knowledge structure and emerging trends AR cancer. The literature from 2000 2021 was obtained Web Science Core Collection (WoSCC), results were analyzed visualized via CiteSpace VOSviewer...

Coexistence of multiple wireless access technologies will be an indicator next-generation network, and the integration heterogeneous networks meet needs high-performance services for mobile users. According to unique quality service (QoS) requirements different type users in environment, Markov decision model based handoff selection algorithm is proposed this paper. A network architecture on software defined (SDN) established realize transparency control networks. Network state information...

A low power and phase noise phase-locked loop (PLL) design for voltage (0.8 V) applications is presented. The controlled oscillator (VCO) operates from a 0.5 V supply, while the other blocks operate 0.8 supply. differential NMOS-only topology adopted oscillator, modified precharge applied in phase-frequency detector (PFD), new feedback structure utilized charge pump (CP) ultra-low applications. divider adopts extended true single clock DFF order to high frequency region save circuit area...

In the paper, by analysing inverse kinematics of 3-RPS DOF parallel mechanism, establish calculation equation between rotation angles and reference point position vector, deduce length formula each electric cylinder. With help MATLAB, calculating corresponding arbitrary cylinder, which is within motion platform, then getting kinematic posture, proved to be correct feasible.

A new mixed mode filter based on MDDCC (Modify Differential Difference Current Conveyor) is proposed, the structure of simple, circuit consist only three active MDDCCs, five resistors and grounded capacitors. The can realize current voltage mode, which function low pass biquad, band biquad high simultaneously. computer simulation PSPICE uses 0.18μm TSMC CMOS theoretical results are validated proposed circuit.

During the use of 6－DOF(six degrees freedom) platform gravity center force tends to deviate from upper platform, resulting in six rods are forced unbalanced. This paper firstly introduces characteristics 6－DOF then establishes simulation model through PRO/E software, and analyses kinematics by ADAMS (Automatic Dynamics Analysis Mechanical System) finally proceeds with dynamics analysis unbalanced condition.Those will get influence degree under force,and provide some proposal for rational platform.

A novel switched-loop filter, which can significantly reduce ripples on voltage controlled oscillator (VCO) control line, is proposed for phase-locked loops (PLL) with an automatic frequency calibration technique. Complementary bootstrapped transmission gates are utilized and rearranged clocks generated to improve the performance of loop filter. Based SMIC 65 nm RF CMOS process, filter applicable 0.8 V 6 GHz PLL technique designed. Transistor level simulation results in SPECTRE show that...

The take-off is the most difficult key technique stage of long jump. related specifications directly affect jumper performance. In this paper, biomechanics study method was used to analyse factors such as last two steps step length and pace, landing angle, pedal sector-shaped jumping initial velocity etc, main influencing were decided, seize these in training will contribute jump level improvement.

Objective: To compare the changes of kinematics and dynamics indexes deep squat, bench press hard pull in order to provide basis for application these three kinds resistance strength training methods. Methods: The kinematic dynamic characteristics 30 young men were measured by real-time wireless sensor motion capture mechanical evaluation system wearable FAB. Results: In terms parameters under 40%1RM 80%1RM load, there significant differences(P < 0.05) flexion angle squat hip joint, knee...

Concrete carbonation resistance is an important embodiment of concrete durability. This article takes National Road 209 line the Shibi Mountain Bridge as research object. A series experiments were did to test The results show that: under a certain mixing radio, T beams, bridge deck, pad stone and thin-walled pier taken from Bridge, which was added admixtures, has less depth. According theoretical calculations, protective layer resists erosion effectively gives good protection on steel reinforcement.

In order that every part of the mechanism is not destroyed in real application, motion 3-RPS parallel mechanisms analyzed, kinematics inverse solution mechanismselongation branch poles solved. The paper based on solution, simulate mechanisms, and get normal mechanismsthe pose top-flat. Compare curves top-flat which are initialized solved by simulation to validate correctness solving methods mechanisms. At same time, provide a way complex

We show the bandpass Chebyshev microwave photonic filter with digital design methods in detail. The structure parameters of are determined by given transfer function wanted spectrum. With those parameters, computer simulation spectrum is good agreement advance designing.