A5102811260- Congenital Heart Disease Studies
- Congenital heart defects research
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Plant tissue culture and regeneration
- Congenital Diaphragmatic Hernia Studies
- Mitochondrial Function and Pathology
- Pregnancy and preeclampsia studies
- Cardiac Arrhythmias and Treatments
- Gastrointestinal disorders and treatments
- Connective tissue disorders research
- Esophageal and GI Pathology
- Vascular anomalies and interventions
- Maternal and fetal healthcare
- Ultrasound in Clinical Applications
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Flowering Plant Growth and Cultivation
- Coronary Artery Anomalies
- Plant Disease Management Techniques
- Weed Control and Herbicide Applications
- Cardiac Imaging and Diagnostics
Sichuan University
2013-2025
West China Second University Hospital of Sichuan University
2020-2025
Guangxi Medical University
2024
Nanchang University
2024
Ministry of Education of the People's Republic of China
2022
Beijing University of Chinese Medicine
2020
West China Hospital of Sichuan University
2015-2018
University of Hong Kong
2013
Chinese University of Hong Kong
2013
Huazhong Agricultural University
2009
The authors declare no conflicts of interest. Data sharing not applicable to this article as datasets were generated or analyzed during the current study.
TGF-β and Hippo signaling are two critical pathways engaged in cancer progression by regulating both oncogenes tumor suppressors, yet how the coordinately exert their functions development of hepatocellular carcinoma (HCC) remains elusive. In this study, we firstly conducted an integrated analysis public liver databases our experimental target genes, identifying CYR61 as a pivotal candidate gene relating to HCC development. The expression is downregulated clinical tissues cell lines than...
A high frequency shoot regeneration system for ornamental kale [Brassica oleracea L. var. acephala (D.C.) Alef.] was firstly established from seedling cotyledon and hypocotyl explants. The ability of to produce adventitious shoots varied depending upon genotype, age culture medium. maximum obtained when the explants cv. Nagoya 4-d-old seedlings were cultured on Murashige Skoog (MS) medium supplemented with 3 mg dm-3 6-benzylaminopurine (BA) 0.1 naphthaleneacetic acid (NAA). 65.0 %...
Nicotinamide phosphoribosyltransferase (NAMPT) has crucial roles for myocardial development, cardiomyocyte energy metabolism and cell death/survival by regulating NAD+-dependent sirtuin-1 (SIRT1) deacetylase. This study aimed to determine if the single nucleotide polymorphisms (SNPs) of NAMPT gene may affect susceptibility prognosis patients with dilated cardiomyopathy (DCM) describe association serum levels clinical features DCM. Three SNPs (rs61330082, rs2505568, rs9034) were analyzed...
Generalized arterial calcification of infancy (GACI) is a rare autosomal recessive disorder characterized by subintimal fibrous proliferation and deposition calcium salts in the internal elastic lamina, leading to extensive stenosis large medium-sized arteries. Prenatal diagnosis usually made third trimester detection aortic pulmonary with associated nonimmune hydrops; earlier prenatal rare. This study was performed examine ultrasound genetic features fetuses GACI.We retrospectively reviewed...
SummaryBy evaluating the effects of culture medium and cold pre-treatment on microspore embryogenesis, we have developed an efficient reliable protocol for doubled-haploid plant regeneration ornamental kale (Brassica oleracea var. acephala). Microspore embryogenesis at high frequency was obtained using a liquid NLN containing 16% (w/v) sucrose (NLN-16) without replacement. Of genotypes tested, cultivar 'Peachy Dancing' produced highest yield embryos (averaging 123.63 per dish). Medium...
Abstract Rationale: Klippel–Trenaunay Syndrome (KTS) is a congenital vascular disease characterized by cutaneous hemangiomas, venous varicosities, and limb hypertrophy. Although extremely rare in pregnant women, the present alterations may be aggravated, consequent to postural hormonal changes inherent pregnancy. Pregnancy not advised KTS women due increased obstetrical risk. Patient concerns: A 31-year-old pregnancy woman presented with prominent vascularity pelvis, right lower limb,...
Immune dysfunction is implicated in dilated cardiomyopathy (DCM). Previous studies found that TIM1 polymorphisms were associated with immune dysfunction. However, the associations between and DCM have not been investigated. Therefore, we conducted present study to evaluate whether Han Chinese population. A total of 396 patients 403 healthy controls enrolled this case-control study. Two promoter region single nucleotide (SNPs) gene, -416G>C -1454G>A, genotyped by PCR-RFLP. The two SNPs...
Abstract A couple was referred for prenatal counseling at the gestational age of 35 weeks a male fetus (II‐2) with sinus bradycardia and suspected first degree atrioventricular block left ventricular noncompaction (LVNC). previous pregnancy female (II‐1) diagnosed prenatally as 30 weeks. Both fetuses were confirmed to have long QT syndrome (LQTS) LVNC after birth, died heart failure during infancy. The genetic cause combined cardiovascular disorders investigated by trio whole‐exome...
A couple was referred for prenatal counseling at gestational age 21 weeks revealed situs inversus with levocardia (HP:0,031,592), atrial (HP:0,011,538), congenitally corrected transposition of the great arteries (ccTGA, HP:0,011,540) ventricular septal defect (HP:0,001,629) and right aortic arch (HP:0,012,020). The had multiple prior pregnancies complex congenital heart defects (CHDs, HP:0,001,627) in male fetuses. Testing initiated to identify any fetal abnormality. genetic cause observed...
Abstract To evaluate the “flow void” diameter in patients with pregnancy-related diseases and without uterine AVMs assess diagnostic performance of unenhanced MRI for AVMs. From May 2014 to April 2019, 79 were included, including 36 43 confirmed by DSA. On MRI, most prominent (hereinafter referred as fv-D) was measured compared between The fv-D estimated receiver operating characteristic curves. sign observed (P > 0.05). significantly larger myometrium parametrium than < 0.0001)....
Early-onset Marfan syndrome (eoMFS) is a rare subset of with varying phenotypic expression that occurs in the neonatal and infantile periods. eoMFS has poor prognosis associated high rates mortality. Most newborn patients present early onset heart failure resistant to treatment. This study presents case eoMFS.
ABSTRACT Objectives To determine the clinical course of fetal isolated non‐immune‐mediated second‐degree atrioventricular block (AVB) and factors associated with spontaneous recovery in these cases. Methods Fetuses AVB were recruited prospectively between 2014 2022. These fetuses divided into two groups: those which recovered spontaneously did not. Maternal characteristics intrauterine postnatal outcomes compared groups. Results The study cohort included 20 AVB, diagnosed at a median...
Objectives There is still no study focused on willingness to pay for long-acting injectable cabotegravir (CAB-LA) after it was available the market in United States 2021. Here, we explored CAB-LA and associated factors price elasticity of demand (PED) among men who have sex with (MSM) Guangxi, China. Methods A cross-sectional conducted. Univariate multivariate ordinal logistic regression analyses were performed explore CAB-LA. PED used measure change number participants willing a price....
Chronic atrophic gastritis (CAG) is an established precursor of gastric carcinoma with high prevalence worldwide. It a typical complex gastro-intestinal disease multiple influence factors, which exact mechanisms remain unelucidated. Therefore, ideal strategy to relieve CAG urgently needed. In recent years, massage therapy has been increasingly accepted by patients due its lower costs, fewer unwanted side effects and safety for clinical use. this systematic review, we aim evaluate the...
Abstract Background: Metatarsalgia refers to localized or generalized forefoot pain in the region of metatarsal heads. Often this is plantar, beneath heads, and arises from either mechanical iatrogenic causes. The treatment metatarsalgia remains controversial. A thorough understanding biomechanics underlying pathology particular type affecting patient a prerequisite selecting proper treatment. In recent years, massage therapy has been increasingly accepted by patients due its lower costs,...
Abstract Anal atresia is the most common malformation occurring in VACTERL association, but it difficult to diagnose antenatally. We herein present a case of fetal anal association diagnosed by ultrasonography and supported autopsy. This emphasizes clues ultrasonographic diagnosis at 11–13 +6 weeks gestation, promoting increased awareness during first‐trimester screening.
To assess the association of polymorphisms oncostatin M receptor (OSMR) gene with dilated cardiomyopathy (DCM) in a Han Chinese population.For 351 DCM patients and 418 healthy controls, two single nucleotide (SNPs) OSMR gene, namely rs2292016 (promoter, -100G/T) rs2278329 (missense, Asp553Asn), were genotyped TaqMan SNP genotyping assay. Two hundred also followed up for (49.85 ± 22.52) months.For rs2292016, carriers GT genotype more likely to develop compared those GG TT genotypes (OR=1.45,...
We herein report what appears to be the first case of fetal non-compaction cardiomyopathy in both ventricles accompanied by a mutation calmodulin gene (CALM2). A 25-year-old woman was referred our hospital at 25+1 weeks gestation for evaluation defects. Prenatal echocardiography showed biventricular with sinus bradycardia. After termination pregnancy, confirmed autopsy and histopathologic examination. Additionally, whole-exome sequencing genomic DNA demonstrated de novo heterozygous (c.389A...
We describe two fetuses with conotruncal heart defects (CTDs) (persistent truncus arteriosus and pulmonary atresia/ventricular septal defect, respectively) in a Chinese family whose parents were both healthy. Testing was performed to identify any underlying genetic cause.Genomic DNA extracted from the peripheral blood of proband's skeletal muscle tissue aborted for testing.A heterozygous likely pathogenic missense variant, c.1724G〉C (:p.Cys575Ser), NOTCH1 gene (NM_017617.5) detected affected...
Abstract Objective(s): To evaluate the “flow void” diameter in patients with pregnancy-related diseases and without uterine AVMs assess diagnostic performance of unenhanced MRI for AVMs. Study Design: From May 2014 to April 2019, 79 were included, including 36 43 confirmed by DSA. On MRI, most prominent (hereinafter referred as fv-D) was measured compared between The fv-D estimated receiver operating characteristic curves. Results: sign observed (P>0.05). significantly larger myometrium...
We describe a fetus from Chinese family whose parents were both healthy but showed multiple malformations, including clubfoot, camptodactyly, micrognathia, and cleft palate. Genomic DNA was extracted the peripheral blood of proband's skeletal muscle tissue aborted to determine diagnosis underlying cause. Whole-exome sequencing revealed that heterozygous for novel variant uncertain significance in exon 56 (c.8576G>A; p.Trp2859*) Piezo-type mechanosensitive ion channel component 2 gene...
Objectives: During Caesarean sections (CS), hypotension is a common complication that can lead to adverse fetal outcomes.Early prediction and intervention help prevent intraoperative hypotension, but there currently no available method accurately predict hypotension.This study aims during CS with deep learning-based models from non-invasive hemodynamic data which are routinely monitored.Methods: A multicentre retrospective was conducted on pregnant women who underwent under spinal...