A5109031189- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Atherosclerosis and Cardiovascular Diseases
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Autism Spectrum Disorder Research
- RNA Research and Splicing
- Chronic Lymphocytic Leukemia Research
- Aquaculture disease management and microbiota
- Receptor Mechanisms and Signaling
- Invertebrate Immune Response Mechanisms
- Retinal Imaging and Analysis
- Advanced Materials and Mechanics
- Kruppel-like factors research
- Axon Guidance and Neuronal Signaling
- Mast cells and histamine
- Dermatologic Treatments and Research
- Health, Environment, Cognitive Aging
- RNA Interference and Gene Delivery
- Genetics and Plant Breeding
- interferon and immune responses
University of Tennessee Health Science Center
2007-2025
Huazhong Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Gaozhou People's Hospital
2015
Nanjing University
2015
South Australian Health and Medical Research Institute
2015
Kunming Medical University
2013-2014
Rosalind Franklin University of Medicine and Science
2011
Nantong University
2006-2007
Sun Yat-sen University
2005-2006
Polymorphism in microRNA Target Site (PolymiRTS) database is a collection of naturally occurring DNA variations putative target sites. PolymiRTSs may affect gene expression and cause complex phenotypes. The integrates sequence polymorphism, phenotype microarray data, characterizes as potential candidates responsible for the quantitative trait locus (QTL) effects. It resource studying their implications phenotypic variations. PolymiRTS can be accessed at http://compbio.utmem.edu/miRSNP/.
To compare the genetic characteristics of normal control group to those neovascular age-related macular degeneration (AMD) patients and detect single-nucleotide polymorphisms (SNPs) related pathogenesis AMD sensitivity anti-VEGF drug, combercept. This is a prospective case-controlled study. A total 104 were treated with combercept 106 subjects served as group. SNPs associated disease susceptibility drug analysed. Significant differences existed between among genotypes two genes, ARMS2...
We recently mapped two quantitative trait loci that have widespread effects on hippocampal architecture in mouse: Hipp1a and Hipp5a . also noted remarkable strain differences the relative sizes of different regions. Estimated heritable variation for these was 42% hippocampus proper, 40% dentate gyrus, 31% granule cell layer 18% pyramidal layer. Region size varied at least 50% from largest to smallest measurement. Here we utilized identify with layer, proper Our sample consists C57BL/6J...
The BXD2 strain of mice is one approximately 80 BXD recombinant inbred (RI) mouse strains derived from an intercross between C57BL/6J (B6) and DBA/2J (D2) strains. We have discovered that adult spontaneously develop generalized autoimmune disease, including glomerulonephritis (GN), increased serum titres rheumatoid factor (RF) anti-DNA antibody, a spontaneous erosive arthritis characterized by mononuclear cell infiltration, synovial hyperplasia, bone cartilage erosion. features lupus...
Abstract The BXD recombinant inbred (RI) mouse strains are the largest and most deeply phenotyped panel of vertebrate organisms. RIs allow phenotyping isogenic individuals across virtually any environment or treatment. We performed whole genome sequencing generated a compendium SNPs, indels, short tandem repeats, structural variants in these used them to analyze phenomic data accumulated over past 50 years. show that BXDs segregate >6 million with high minor allele which dervied from...
Natural variation in the absolute and relative size of different parts human brain is substantial, with a range that often exceeds factor 2. Much this generated by cumulative effects sets unknown gene variants modulate proliferation, growth death neurons glial cells. Discovering testing functions these genes should contribute significantly to our understanding differences development, behavior disease susceptibility. We have exploited large population genetically well-characterized strains...
BackgroundThe DBA/2J mouse is not only the oldest inbred strain,but also one of most widely used strains. DBA/2Jexhibits many unique anatomical, physiological, andbehavior traits. In addition, parent thelarge BXD family recombinant strains [1]. Thegenome other this family—C57BL/6J—has been sequenced and serves as themouse reference genome [2]. We gen-ome using SOLiD Illumina highthroughput short read protocols to generate a compre-hensive set ~5 million sequence variants segregatingin that...
Neurexin 1 (NRXN1) is a large presynaptic transmembrane protein that has complex and variable patterns of expression in the brain. Sequence variants NRXN1 are associated with differences cognition, schizophrenia autism. The murine Nrxn1 gene also highly polymorphic significant variation under strong genetic control. Here, we use co-expression analysis, high coverage genomic sequence, quantitative trait locus (eQTL) mapping to study regulation this We profiled family 72 isogenic progeny...
Abstract Objective: This study aimed to investigate the long-term efficacy of intratympanic methylprednisolone perfusion treatment for intractable Ménière's disease. Methods: A retrospective analysis 17 disease patients treated with was performed. Treatment evaluated according American Academy Otolaryngology–Head and Neck Surgery criteria. Short control or improvement rates were calculated after 6 24 months, respectively. Results: Sixteen followed more than two years. Short- vertigo 94 per...
DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsSpecials 67:171-176 (2005) - doi:10.3354/dao067171 Comparison a novel in situ polymerase chain reaction (ISPCR) method other methods for white spot syndrome virus (WSSV) detection Penaeus vannamei Xu-feng Jian1, Ling Lu1, Yong-gui Chen1, Siu-Ming Chan2, Jian-guo He1,* 1State Key Laboratory Biocontrol, School Life Sciences,...
Background Over the past decade many linkage studies have defined chromosomal intervals containing polymorphisms that modulate a variety of traits. Many phenotypes are now associated with enough mapping data meta-analysis could help refine locations known QTLs and detect novel QTLs. Methodology/Principal Findings We describe simple approach to combining QTL results for multiple demonstrate its utility using two hippocampus weight loci. Using taken from populations, recombinant inbred strain...
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To investigate the effect of methylene blue (MB) on renal ischemia-reperfusion (IR) injury in mice and its possible relevant mechanisms.A total 30 male C57/BL6 aged 4 months old were randomly divided into following three groups: Sham group (n=10), IR MB (n=10). Mice treated with gavage continuously using solution (dosage: 25 mg·kg-1·d-1) until they 7 old. other two groups administrated same amount normal saline for gavage. After that, abdomen was opened closed, bilateral pedicles occluded a...
Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERT) regulate 5-HT signaling via antidepressant-sensitive clearance of released neurotransmitter. Polymorphisms in the human SERT gene (SLC6A4) have been linked to risk for multiple neuropsychiatric disorders, including depression, obsessive-compulsive disorder and autism. Using BXD recombinant inbred mice, a genetic reference population that can support discovery novel determinants complex traits, merging collective trait...