Abstract Background Adequate physical activity (PA) is essential for preventing sarcopenia in older adults. However, there are insufficient epidemiological data on the intensity of PA needed to prevent age-related sarcopenia. The purpose this study was investigate association with skeletal muscle mass and strength. Methods This a population-based cross-sectional design that conducted using from 2008 − 2011 2014 2018 Korea National Health Nutrition Examination Surveys, which included total...

Human corneal endothelial cells (hCECs) have been considered unable to regenerate in vivo, resulting decompensation after significant loss of hCECs. adipose-derived mesenchymal stem cell (ASC)-derived exosomes can tissues and organs. In this study, we investigated whether ASC-derived could protect CECs.We performed viability cell-cycle analyses evaluate the effect on regeneration capacity cultured Transforming growth factor-β (TGF-β) hydrogen peroxide (H2O2) were used induce biological...

Purpose.: To investigate the characteristics of lamina cribrosa (LC) depth in healthy eyes using enhanced imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Methods.: Serial horizontal B-scans optic nerve head were obtained EDI SD-OCT for both 150 subjects. Anterior LC surface (ALCS) depths measured with B-scan images from equidistant planes each eye and defined as distance Bruch's membrane opening plane to anterior surface. The ALCS compared between within subject. A...

Purpose.: To investigate the diagnostic ability of posterior pole asymmetry analysis (PPAA) with spectral domain optical coherence tomography (SD-OCT) for detecting localized retinal nerve fiber layer defects (RNFLD). Methods.: Eighty-four open-angle glaucoma subjects (84 eyes) localized, wedge-shape RNFLDs by red-free RNFL photography and 122 eyes healthy were enrolled. The examined SD-OCT to obtain circumpapillary (cpRNFL) thickness as well PPAA. PPAA provides a corresponding cell...

Abstract Sarcopenia is an age-related disorder characterised by a progressive decrease in skeletal muscle mass. As the genetic biomarkers for sarcopenia are not yet well characterised, this study aimed to investigate variations related relatively aged cohort, using genome-wide association (GWAS) meta-analyses of lean body mass (LBM) 6961 subjects. Two Korean cohorts were analysed, and subgroup GWAS was conducted appendicular (ASM) index. The effects significant single nucleotide...

Researchers have proposed a possible correlation between age-related macular degeneration (AMD) and inflammation or C-reactive protein (CRP) levels. We investigated the potential causal relationship CRP levels AMD. Single-nucleotide polymorphisms (SNPs) associated with exposure were selected as instrumental variables (IVs) significance (p < 5 × 10−8) from genome-wide association study (GWAS) meta-analysis data of Biobank Japan UK Biobank. GWAS for AMD obtained 11 International Genomics...

Aims/Purpose: To investigate the genetic loci related of disc hemorrhage (DH) using genome‐wide association studies (GWAS) and causal between DH primary open‐angle glaucoma (POAG) in East Asian population. Methods: The GWAS was conducted on 8,488 Koreans who underwent ocular examination fundus photography to determine presence POAG. After identifying significant single nucleotide polymorphisms (SNPs) associated with DH, we an analysis heritability correlation for SNPs discovered current...

Background/Objectives: Individuals with metabolic syndrome (MetS) present reduced 25(OH)D levels. We performed a two-sample Mendelian randomization (MR) study to investigate whether causal relationships exist between levels and MetS/MetS risk traits, including waist circumference, body mass index (BMI), hypertension (systolic/diastolic blood pressure), triglyceride, high-density lipoprotein cholesterol, glucose Methods: employed genetic variants related from the SUNLIGHT Consortium European...

Primary open-angle glaucoma (POAG) is the leading cause of irreversible vision loss. However, its genetic risk factors, such as vascular hypothesis POAG, remain unclear. Here, we aimed to explore associations between mean ocular perfusion pressure (MOPP) and POAG. We performed genome-wide analysis with gene-based from UK Biobank (N = 459,195), which includes data phenotypes. Bidirectional two-sample Mendelian randomisation (MR), multivariable MR, mediation were conducted using summary...

Abstract We conducted a comprehensive genetic investigation of obesity in cohort 93,673 Korean individuals, categorized by both body mass index and waist circumference using Korean-specific international criteria. To explore the architecture its comorbidities, we performed genome-wide association studies constructed polygenic risk scores (PRSs) conventional single trait advanced multiple-trait models, including PRSsum approach. Our analyses identified significant loci demonstrated higher...

Précis: Higher self-reported physical activity level was associated with a slower rate of visual field mean deviation loss in patients primary open-angle glaucoma. Purpose: To determine the impact (PA) on (VF) progression rates glaucoma (POAG). Methods: In this longitudinal study, POAG were included who had ≥5 visits, ≥2 years follow-up VFs and underwent PA questionnaire at baseline. levels assessed using index (PAI), metabolic equivalents task (MET)-minutes, walking pace. Univariable...

This study investigated whether filtering blebs can be evaluated using optical coherence tomography angiography (OCT-A) and compared vascularity parameters with conventional bleb grading systems.A total of 92 patients glaucoma, who underwent mitomycin C-augmented trabeculectomy, were enrolled in this study, eyes assessed total. The participants OCT-A external mode anterior segment photography for evaluation. For evaluation vascularity, a blinded observer carefully drew the area on original...

Researchers have suggested a potential relationship between gamma-glutamyl transferase (GGT) level and stroke. We investigated causal GGT as exposures stroke subtypes (cardioembolic, small vessel, large artery) in European population. performed two-sample Mendelian randomization (MR) study using the genome-wide association (GWAS) data from UK Biobank exposure set. For outcome set, we used GWAS GIGASTROKE Consortium. considered alcohol consumption, atrial fibrillation, body mass index...

Common age-related eye disorders include glaucoma, cataract, and macular degeneration (AMD); however, little is known about their relationship with age. This study investigated the potential causal between glaucoma AMD cataract using genetic data from multi-ethnic populations. Single-nucleotide polymorphisms (SNPs) associated exposure to were selected as instrumental variables (IVs) genome-wide association studies meta-analysis BioBank Japan UK Biobank. A bidirectional two-sample Mendelian...

To investigate the effects of anterior chamber depth (ACD) and white-to-white (WTW) diameter on vault in eyes with implantable collamer lenses (ICL V4, STAAR Surgical AG) to evaluate effect visual outcomes other biometric changes.Twenty-eight 16 patients who underwent ICL implantation were retrospectively reviewed. Patients divided into two groups (A1, A2) according preoperative ACD (> or = 3.3 mm < mm, respectively), (B1, B2) based WTW 11.55 (C1, C2) difference sulcus length 0.25...

Purpose: The microbiome is considered an environmental factor that contributes to the progression of several neurodegenerative diseases. However, association between and glaucoma remains unclear. This study investigated features oral in patients with analyzed biomarker candidates using a machine learning approach predict severity glaucoma.Methods: taxonomic composition was obtained 16S rRNA gene sequencing, operational unit analysis, diversity analysis. differentially expressed (DEG)...

Abstract Background Sarcopenia is characterized by a progressive decrease in skeletal muscle mass and function with age. Given that sarcopenia associated various metabolic disorders, effective biomarkers for its early detection are required. We aimed to investigate the related elderly men perform experimental studies using metabolomics. Methods Plasma metabolites from 142 men, comprising group an age‐matched control group, were measured global metabolome profiling. Muscle plasma samples...

The pathogenesis of diabetic kidney disease (DKD) is complex, involving metabolic and hemodynamic factors. Although DKD has been established as a heritable disorder several genetic studies have conducted, the identification unique variants for limited by its multiplex classification based on phenotypes diabetes mellitus (DM) chronic (CKD). Thus, we aimed to identify related that differentiate it from type 2 DM CKD.We conducted large-scale genome-wide association study mega-analysis,...

To compare the features of localized retinal nerve fiber layer (RNFL) defects between a low-teen intraocular pressure (IOP) group and high-teen IOP in normal-tension glaucoma (NTG) patients.Seventy-seven eyes 77 NTG patients showing RNFL on photographs corresponding visual filed at initial visit to specialist were selected for this study. Patients with range diurnal within or both included. All participants completed refraction, measurement, central corneal thickness (CCT) stereoscopic disc...

A bstract Purpose: To investigate if antituberculosis medication including ethambutol could be a possible epigenetic factor in visual loss Leber's hereditary optic neuropathy (LHON). Methods: The authors reviewed the medical records of 46 patients registered at Bundang Seoul National University Hospital from 2002 to 2006, who developed typical clinical neuro‐ophthalmologic features LHON and possessed mtDNA mutation nucleotide 11778, 14484, 3460 or 4171. Results: Three while taking...