A5058878178- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Toxoplasma gondii Research Studies
- Photodynamic Therapy Research Studies
- Phagocytosis and Immune Regulation
- Calcium signaling and nucleotide metabolism
- Adipose Tissue and Metabolism
- thermodynamics and calorimetric analyses
- Metal complexes synthesis and properties
- Cancer Cells and Metastasis
- Metabolism and Genetic Disorders
- Cell death mechanisms and regulation
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
Cornell University
2023-2025
Weill Cornell Medicine
2024-2025
Universidad de Zaragoza
2022-2024
Instituto de Investigación Sanitaria Aragón
2022-2024
United States University
2024
Mitochondrial function generates an important fraction of the heat that contributes to cellular and organismal temperature maintenance, but actual values this parameter reached in organelles is a matter debate. The studies addressing issue have reported divergent results: from detecting same as cell average or incubation temperature, increasing differences up 10 degrees above value. Theoretical calculations based on physical laws exclude possibility relevant gradients between mitochondria...
Abstract In 2023, an estimated 297,790 new cases of invasive breast cancer (BC) have been diagnosed to women in the US, causing 55,720 deaths, most which originated from hormone receptor (HR+) BC. this sense, radiation therapy (RT) has attracted attention as a potential tool convert HR+ BCs that are scarcely infiltrated by immune cells (so-called ‘cold’) into highly ‘hot’) checkpoint blockers (ICB)-responsive tumors thanks, among other factors, release damage-associated molecular patterns...
Abstract Background Hormone receptor (HR)+ breast cancer is poorly responsive to immune checkpoint inhibitors (ICIs). In some settings, radiation therapy (RT) has been shown mediate immunostimulatory effects and promote ICI sensitivity. Methods We investigated whether hypofractionated RT may be successfully combined with ICIs in a mouse model of multifocal, metachronous HR+ mammary carcinogenesis. hypothesized that focal targeting the first detectable (primary) tumor generate effective...
As the last step of OXPHOS system, mitochondrial ATP synthase (or complex V) is responsible for production by using generated proton gradient, but also has an impact on other important functions linked to this system. Mutations either in V structural subunits, especially mtDNA-encoded ATP6 gene, or its assembly factors, are molecular cause a wide variety human diseases, most them classified as neurodegenerative disorders. The role alterations cancer development metastasis been postulated. In...
In recent years, the number of studies dedicated to ascertaining connection between mitochondria and cancer has significantly risen. However, more efforts are still needed fully understand link involving alterations in tumorigenesis, as well identify tumor-associated mitochondrial phenotypes. For instance, evaluate contribution tumorigenesis metastasis processes, it is essential influence from tumor cells different nuclear environments. this purpose, one possible approach consists...
PT-112 is a novel pyrophosphate-platinum conjugate, with clinical activity reported in advanced pretreated solid tumors. While has been shown to induce robust immunogenic cell death (ICD) vivo but only minimally bind DNA, the molecular mechanism underlying target disruption cancer cells still under elucidation. The murine L929 vitro system was used test whether differential metabolic status alters PT-112's effects, including cytotoxicity. results showed that tumor presenting mutations...
PT-112 is a novel immunogenic cell death (ICD)-inducing small molecule currently under Phase 2 clinical development, including in metastatic castration-resistant prostate cancer (mCRPC), an immunologically cold and heterogeneous disease state need of therapeutic approaches. has been shown to cause ribosome biogenesis inhibition organelle stress followed by ICD cells, culminating anticancer immunity. In addition, evidence PT-112-driven immune effects observed patient immunoprofiling. Given...
Nine kDa granulysin (GRNLY) is a human cytolytic protein secreted by cytotoxic T lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological function elimination bacteria parasites. In previous studies our group, anti-tumor capacity recombinant was demonstrated, both in vitro vivo. present work, we developed lipid nanoparticles surfaces can bind through formation complex coordination between histidine tail Ni2+ provided chelating liposome composition termed them...
In recent years, the number of studies dedicated to ascertaining connection between mitochondria and cancer has significantly risen. However, more efforts are still needed fully understand link involving alterations in tumorigenesis, as well identify tumor-associated mitochondrial phenotypes. For instance, evaluate contribution tumorigenesis metastasis processes, it is essential influence from tumor cells different nuclear environments. this purpose, one possible approach consists...
Abstract Purpose: To investigate PT-112 in a human prostate cancer (PC) cell panel and assess differential sensitivity, death mechanism, induction of mitochondrial stress, release damage-associated molecular patterns (DAMPs). Background: is novel pyrophosphate-platinum conjugate with clinical activity advanced solid tumors including lung, thymoma castration-resistant PC, multiple myeloma. PT-112’s was shown previously to be independent DNA damage. In vitro vivo mouse experiments have that...