A5041297443- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Insect Pest Control Strategies
- CRISPR and Genetic Engineering
- Wildlife Ecology and Conservation
- Chromosomal and Genetic Variations
- Zoonotic diseases and public health
- Parasites and Host Interactions
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
Institut de Recherche en Sciences de la Santé
2017-2025
Centre National de la Recherche Scientifique et Technologique
2025
Institut des Sciences des Sociétés
2017-2024
Centre Muraz
2013-2023
In the context of widespread mosquito resistance to currently available pesticides, novel, precise genetic vector control methods aimed at population suppression or trait replacement are a potentially powerful approach that could complement existing malaria elimination interventions. Such require knowledge composition, dynamics, behaviour and role in transmission. Here were characterized these parameters three representative villages, Bana, Pala Souroukoudingan, Sudano-Sahelian belt Burkina...
Vector control is a major component of the malaria strategy. The increasing spread insecticide resistance has encouraged development new tools such as genetic which use releases modified male mosquitoes. mosquitoes part strategy requires an improved understanding mosquito biology, including factors influencing their survival and dispersal, well ability to accurately estimate size target population. This study was designed determine seasonal variation in population via repeated...
Abstract Every year, malaria kills approximately 405,000 people in Sub-Saharan Africa, most of them children under the age five years. In many countries, progress control has been threatened by rapid spread resistance to antimalarial drugs and insecticides. Novel genetic mosquito approaches could play an important role future integrated strategies. July 2019, Target Malaria consortium proceeded with first release hemizygous genetically-modified (GM) sterile non-transgenic sibling males...
Malaria control programs are being jeopardized by the spread of insecticide resistance in mosquito vector populations. It has been estimated that could lead to an additional 120000 deaths per year, and interfere with prospects for sustained or feasibility achieving malaria elimination. Another complication development management strategies is that, addition resistance, behavior evolves a manner diminishes impact LLINs IRS. Mosquitoes may circumvent LLIN IRS through preferential feeding...
Effective tools to prevent mosquito bites are essential for malaria control. The Lehmann Funnel Entry Trap (LFET), a window screen proven effective in reducing density, was tested its large-scale impact on vector control and community acceptance. A total of 1313 traps were deployed Vallée du Kou 3 (VK3), with 12 randomly selected detailed evaluation against untrapped houses 5 (VK5). Traps placed windows doors blocked by curtains. From July October, mosquitoes collected nine days per month...
Malaria transmission in Burkina Faso is continuous throughout the year. Anthropogenic changes environment affect risk of disease and ability communities to respond. This study aimed evaluate resilience two different malaria settings Western by examining their absorb, adapt, transform regarding burden. Conducted Faso, this focused on localities, Bana VK5, representing distinct settings: a natural savannah rice-growing environment. A mixed-methods approach was employed study. Quantitative data...
Intensive deployment of insecticide based malaria vector control tools resulted in the rapid evolution phenotypes resistant to these chemicals. Understanding this process at genomic level is important for successful interventions. Therefore, longitudinal sampling followed by whole genome sequencing (WGS) necessary understand how evolutionary processes evolve over time. This study investigated change genetic structure and resistance variants natural populations Anopheles gambiae time space...
Abstract Background One of the promising current approaches to curb malaria lies in genetic vector control, implementation which will require an improved understanding movement constructs among mosquito populations. To predict potential gene flow from one area another, it is important begin understand dynamics outside commonly-sampled village areas, and thus how genes may move between villages. This study assessed presence relative abundance mosquitoes a 6-km corridor two villages western...
Abstract Intensive deployment of insecticide based malaria vector control tools results in the rapid evolution phenotypes resistant to these chemicals. Understanding this process on genomic level is essential for successful interventions. Using whole genome sequencing data 1409 individual An. Gambiae s.l. collected from 2012 2017, we investigated change genetic structure and resistance variants natural populations over time space. The showed similar constant nucleotide diversity negative...
Insecticides are currently the main tools used to reduce transmission of malaria; therefore, development resistance insecticides in malaria vectors is major concern for control. The level pyrethroids particularly high Western region Burkina Faso and may affect efficacy insecticidal bed nets indoor residual spraying. Adult mosquito swarming other nocturnal behaviours exhibit spatial temporal patterns that suggest potential vulnerability targeted space spraying with effective insecticides....
Abstract Background Since the late 1990s, malaria control programmes have relied extensively on mass bednet distribution and indoor residual spraying. Both interventions use pesticides target mosquitoes coming indoors either to feed or rest. Unfortunately, these intensified vector campaigns resulted in mosquito populations with high levels of resistance most chemical compounds used against them which are increasingly exophagic exophillic, hence difficult monitor indoors. Consequently, there...
Abstract Outdoor biting constitutes a major limitation of current vector control based primarily on long-lasting insecticidal nets and indoor residual spraying, both which are interventions. Consequently, malaria elimination will not be achieved unless additional tools found to deal with the transmission associated dynamics. In this study we tested new approach for rapidly crashing mosquito populations disrupting in Africa. This method targets previously neglected swarming outdoor nocturnal...
Malaria is a permanent threat to health in western Burkina Faso. Research has shown that geographical variables contribute the spatial distribution its transmission. The objective of this study assess relationship between malaria prevalence and potential explanatory Houet province Statistics on registered by centres 2017 identified through literature review were collected. An Ordinary Least Squares (OLS) regression was used identify key measure their association with while Getis Ord Gi*...
<title>Abstract</title> Background The recent success of a population control gene drive targeting the <italic>doublesex</italic> in <italic>Anopheles gambiae</italic> paved way for development self-sustaining and self-limiting genetic strategies sex determination pathway to reduce and/or distort reproductive capacity insect vectors. However, these genes purposes requires better understanding their variation natural populations ensure effective spread. Using whole genome sequencing data from...
Abstract Background The recent success of a population control gene drive targeting the doublesex in Anopheles gambiae paved way for developing self-sustaining and self-limiting genetic strategies sex determination pathway to reduce and/or distort reproductive capacity insect vectors. However, these genes requires better understanding their variation natural populations ensure effective spread. Using whole genome sequencing (WGS) data from Ag1000G project (Ag3.0, 3.4 3.8), Illumina pooled...
Abstract Background There is a great need to find new effective tools prevent mosquitoes from biting humans. As part of this search, the Lehmann Funnel Entry Trap, window screen, was tested and has proven be in mosquito density reduction low high vector settings. Here we aimed assess whether large-scale deployment pyriproxyfen-treated traps can control malaria populations how well were accepted at community level. Method Overall, 1,313 impregnated with Pyriproxyfen (PPF) deployed. Of these,...
Resistance to insecticides in the mosquito Anopheles gambiae s.l can jeopardize malaria vector control strategies. Previous studies have shown that agricultural chemicals, used particularly for cotton protection, selected insecticide resistant vectors. Our study aimed at assessing impact of three pest management strategies different ecological settings (conventional, organic and transgenic growing areas) on i) susceptibility belonging pyrethroids, DDT, carbamate organophosphate tested main...
Abstract Background: The Lehmann Funnel Entry Trap has proven to be effective in catching and killing up 70% of mosquitoes even a high mosquito density setting. A medium-sized prototype was selected deployed at large scale Vallée du Kou 3 (VK3) the Southwest Burkina Faso assess its entomological sociological impact. Method: Overall, 1,313 traps impregnated with Pyriproxyfen (PPF), were deployed. Of them, 12 randomly across intervention village compared houses without control village, 5...