A5030752489- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Mycotoxins in Agriculture and Food
- Fungal Plant Pathogen Control
- Magnetism in coordination complexes
- Metal-Organic Frameworks: Synthesis and Applications
- Fungal and yeast genetics research
- Antibiotic Resistance in Bacteria
- Biotechnology and Related Fields
- Molecular Sensors and Ion Detection
- Bioeconomy and Sustainability Development
- Asymmetric Hydrogenation and Catalysis
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Agriculture, Plant Science, Crop Management
- Genomics, phytochemicals, and oxidative stress
- Organometallic Compounds Synthesis and Characterization
- Coordination Chemistry and Organometallics
- Advanced biosensing and bioanalysis techniques
- Fermentation and Sensory Analysis
- Autophagy in Disease and Therapy
- Ferrocene Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Organometallic Complex Synthesis and Catalysis
University of Parma
2016-2022
In-Q-Tel
2016
Abstract Metal complexes still represent promising pharmacological tools in the development of new anticancer drugs. Bis(citronellalthiosemicarbazonate)nickel(ii) is a metal compound extremely effective against leukemic and NCS cancer cell lines. Preliminary experiments performed with this its Cu(ii) Pt(ii) analogues evidenced alterations, detectable by comet assay, DNA treated U937 cells. In addition, [Cu(tcitr)2] [Pt(tcitr)2] were also able to induce gene mutations produce frameshift...
A comparative study between two bisthiosemicarbazones, 2,3-butanedione bis(4,4-dimethyl-3-thiosemicarbazone) and bis(2-methyl-3-thiosemicarbazone), their copper(ii) complexes is reported. The four compounds have been tested on a leukemia cell line U937 (p53-null) an adenocarcinoma A549. includes viability, cycle, morphological changes, assessment of apoptosis, analysis autophagy, measurement reactive oxygen species (ROS) lipid peroxidation, protein determination, the expression p53 cellular...
Naphthalenediimide derivates are a class of π-conjugated molecules largely investigated in the literature and used as building blocks for metal-organic frameworks or coformers hydrogen-bond-based cocrystals. However, their tendency to establish halogen-bond interactions remains unexplored. By using crystalline engineering approach, we report here four new cocrystals with N,N'-di(4-pyrydyl)-naphthalene-1,4,5,8-tetracarboxidiimide diiodo-substituted coformers, easily obtained via...
Great are the expectations for a new generation of antimicrobials, and strenuous research efforts towards exploration diverse molecular scaffolds-possibly natural origin - aimed at synthesis compounds against spread hazardous fungi. Also high but winding paths leading to definition biological targets specifically fitting drug's structural characteristics. The present study is addressed inspect differential behaviours cinnamaldehyde benzaldehyde thiosemicarbazone scaffolds, exploiting...
Abstract A series of half‐sandwich Ru II complexes containing two pairs isomeric pyridine‐functionalized 1,8‐naphthalimides were synthesized and fully characterized. The solid state structures three out the eight also determined. ligands obtained reacting 1,8‐naphtalenic anhydride with 4‐aminopyridine (ligand L1 ), 3‐aminopyridine L2 4‐aminomethylpyridine L3 ) 3‐aminomethylpyridine L4 ). Each ligand was used to synthesize a pair complexes: neutral one, formula [(p‐cymene)RuLCl 2 ], an ionic...
The synthesis, photoactivation and biological activity of a new piano-stool Ru(II) complex is herein reported. peculiarity this that its monodentate ligand which undergoes the photodissociation an asymmetric bis-thiocarbohydrazone possesses pyridine moiety binding to other contains quinoline endows with capacity chelating metal ions. In way, upon dissociation, can be released in form complex. article, double ability photorelease chelate copper nickel explored confirmed. compound studied cell...
The control of the fungal contamination on crops is considered a priority by sanitary authorities an increasing number countries, and this also due to fact that geographic areas interested in mycotoxin outbreaks are widening. Among different pre- post-harvest strategies may be applied prevent and/or aflatoxin contamination, fungicides still play prominent role; however, despite countless efforts, date problem food feed remains unsolved, since essential factors affect aflatoxins production...
Amongst the various approaches to contain aflatoxin contamination of feed and food commodities, use inhibitors fungal growth and/or toxin biosynthesis is showing great promise for implementation or replacement conventional pesticide-based strategies. Several inhibition mechanisms were found taking place at different levels in biology aflatoxin-producing species such as Aspergillus flavus: compounds that influence production may block biosynthetic pathway through direct control genes...
We report the synthesis and characterization of three half-sandwich Ru(II) arene complexes [(η6-arene)Ru(N,N')L][PF6]2 containing = p-cymene, N,N' bipyridine, L pyridine meta- with methylenenaphthalimide (C1), methylene(nitro)naphthalimide (C2), or methylene(piperidinyl)naphthalimide (C3). The naphthalimide acts as an antenna for photoactivation. After 3 h irradiation blue light, monodentate pyridyl ligand had almost completely dissociated from complex C3, which contains electron donor on...