A5089398863- Carcinogens and Genotoxicity Assessment
- Chemotherapy-induced cardiotoxicity and mitigation
- Genomics, phytochemicals, and oxidative stress
- Mycotoxins in Agriculture and Food
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Advances in Cucurbitaceae Research
- Amino Acid Enzymes and Metabolism
- Effects and risks of endocrine disrupting chemicals
- Antimicrobial Peptides and Activities
- Heavy metals in environment
- Biochemical and Structural Characterization
- Chronic Myeloid Leukemia Treatments
- Plant Stress Responses and Tolerance
- Aluminum toxicity and tolerance in plants and animals
- Biopolymer Synthesis and Applications
- Biochemical effects in animals
- Plant Pathogens and Resistance
- Cardiac Ischemia and Reperfusion
- Antifungal resistance and susceptibility
- Indoor Air Quality and Microbial Exposure
- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Agriculture, Plant Science, Crop Management
- Antibiotic Resistance in Bacteria
University of Parma
2011-2022
Polytechnic University of Turin
2019
Autophagy is a catabolic pathway activated in response to different cellular stressors, such as damaged organelles, accumulation of misfolded or unfolded proteins, ER stress, reactive oxygen species, and DNA damage. Some damage sensors like FOXO3a, ATM, ATR, p53 are known be important autophagy regulators, seems therefore have role (DDR). Recent studies partly clarified the pathways that induce during DDR, but its precise still not well known. Previous shown alterations an increase...
Synthetic peptides with sequences identical to fragments of the constant region different classes (IgG, IgM, IgA) antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin triazole resistant strains. Alanine-substituted derivatives Fc-peptides, tested evaluate critical role each residue, displayed unaltered, increased or decreased candidacidal vitro. An...
Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants whose levels have increased in the environment and human tissues past decades. Exposure to PBDEs has been associated with developmental neurotoxicity, endocrine dysfunction, reproductive disorders. In spite their widespread distribution potential adverse health effects, only few studies addressed neurotoxicity PBDEs. present study, we evaluated cyto- genotoxicity 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) decabrominated...
Nitroheterocyclic compounds are widely used as therapeutic agents against a variety of protozoan and bacterial infections. However, the literature on these compounds, suspected being carcinogens, is controversial. In this study, cytotoxic genotoxic potential three drugs, Nifurtimox (NFX), Benznidazole (BNZ), Metronidazole (MTZ) was re-evaluated by different assays. Only NFX reduces survival rate in actively proliferating cells. The more active for base-pair substitution than frameshift...
Abstract Background Nanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the cellular level, causing harmful conditions, have yet to be established. This particularly true in case of cardiovascular system, where experimental clinical evidence shows morphological functional damage associated NP exposure. Giving increasing interest cobalt oxide (Co 3 O 4 ) NPs applications industrial bio-medical fields, a detailed...
Abstract Excess heavy metals affect plant physiology by inducing stress symptoms, however several species have evolved the ability to hyperaccumulate in above‐ground tissues without phytotoxic effects. In this study we assume that at subcellular level, different strategies were adopted hyperaccumulator versus non‐accumulator face excess of metals. At purpose comet assay was used investigate nucleoid structure modifications occurring response Zn and Cd treatments I16 PL22 populations...
Epidemiological evidence shows that regular consumption of Brassicaceae is associated with a reduced risk cancer and heart disease. Cruciferous species are usually processed before eating the real impact cooking practices on their bioactive properties not fully understood. We have evaluated effect common (boiling, microwaving, steaming) biological activities broccoli, cauliflower Brussels sprouts. Anti-proliferative chemoprotective effects towards DNA oxidative damage fresh cooked vegetable...
In early diabetes, hyperglycemia and the associated metabolic dysregulation promote changes in functional properties of cardiomyocytes, progressively leading to appearance diabetic cardiomyopathy phenotype. Recently, interplay between histone acetyltransferases (HAT) deacetylases (HDAC) has emerged as a crucial factor development cardiac disorders. The present study evaluates whether HDAC inhibition can prevent cardiomyocyte contractile dysfunction induced by short period hyperglycemia, with...
Evidence from previous works disclosed the antimicrobial, antiviral, anti-tumour and/or immunomodulatory activity exerted, through different mechanisms of action, by peptides expressed in complementarity-determining regions or even constant region antibodies, independently their specificity and isotype. Presently, we report selection, available databases, peptide sequences encoded immunoglobulin genes for evaluation potential biological activities. Synthetic representing translated products...
A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved exert a potent vitro activity against fungal pathogens, and inhibit HIV-1 replication ex vivo. It also showed therapeutic effect an experimental infection Candida albicans invertebrate model Galleria mellonella. represents proof concept innate role that naturally occurring antibody fragments may...
Methionine deprivation of cancer cells, which are deficient in methionine biosynthesis, has been envisioned as a therapeutic strategy to reduce cell viability. γ-lyase (MGL), an enzyme that degrades methionine, exploited selectively remove the amino acid from environment. In order increase MGL catalytic activity, we performed sequence and structure conservation analysis MGLs various microorganisms. Whereas most residues active site at dimer interface were found be conserved, located...
Background In the Po Valley aflatoxins play a relevant role: local food economy is heavily based on cereal cultivations for animal feed and human nutrition. Aims of this project are identification new compounds that inhibit Aspergillus proliferation, development inhibitors production, set-up practical screening procedure to identify most effective safe compounds. Design Methods New will be synthetized with natural origin molecules as ligands endogenous metal ions increase their...
The growing problem of antimicrobial resistance highlights the need for alternative strategies to combat infections. From this perspective, there is a considerable interest in natural molecules obtained from different sources, which are shown be active against microorganisms, either alone or association with conventional drugs. In paper, peptides same sequence fragments, found human serum, derived physiological proteins, were evaluated their antifungal activity. A 13-residue peptide,...
Abstract In this study, we assess the DNA damage occurring in response to cadmium (Cd) Cd hyperaccumulator Noccaea caerulescens Ganges (GA) vs non-accumulator and close-relative species Arabidopsis thaliana . At purpose, alkaline comet assay was utilized evaluate Cd-induced variations nucleoids methy-sens assay, semiquantitative real-time (qRT)-PCR were also performed associate nucleus possible modifications. Cadmium induced high damages nuclei of A. while only a small increase migration...
The control of the fungal contamination on crops is considered a priority by sanitary authorities an increasing number countries, and this also due to fact that geographic areas interested in mycotoxin outbreaks are widening. Among different pre- post-harvest strategies may be applied prevent and/or aflatoxin contamination, fungicides still play prominent role; however, despite countless efforts, date problem food feed remains unsolved, since essential factors affect aflatoxins production...
The emergence of the Internet Things, which enables connection almost every building-element to Internet, provides a huge and appealing amount data Smart Building City ecosystem. These also create value by enriching offer quality applications designed for optimal management energy efficiency. topic saving has been evaluated 119 buildings managed Territorial Agency House (ATC) in 9 districts Turin. All useful information, concerning sample analyzed, were collected; particular, its...
Aims: Citrullus colocynthis is a plant endemic in Asia, Africa and the Mediterranean basin.It used folk medicine against infections, inflammations cardiovascular immune-related diseases.There are further evidences of use Schrad treatment cancer traditional practices.The present study aimed to determine potential antiproliferative effects different leaf extracts on human cells.Methodology: Antiproliferative antioxidant HT-29 colon cells were detected by MTS assay modified protocol alkaline...