A5089251053- Osteoarthritis Treatment and Mechanisms
- Bone health and osteoporosis research
- Lower Extremity Biomechanics and Pathologies
- Nutrition and Health in Aging
- Chronic Disease Management Strategies
- Frailty in Older Adults
- Obesity, Physical Activity, Diet
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Musculoskeletal Disorders and Rehabilitation
- Body Composition Measurement Techniques
- Rheumatoid Arthritis Research and Therapies
- Nutritional Studies and Diet
- Knee injuries and reconstruction techniques
- Immune Cell Function and Interaction
- Hip and Femur Fractures
- Health and Well-being Studies
- Hip disorders and treatments
- Inflammatory mediators and NSAID effects
- Physical Activity and Health
- Medical and Biological Sciences
- Total Knee Arthroplasty Outcomes
- Vitamin D Research Studies
- T-cell and B-cell Immunology
- Cystic Fibrosis Research Advances
MRC Lifecourse Epidemiology Unit
2014-2024
University of Southampton
2014-2024
Southampton General Hospital
2014-2022
Medical Research Council
2015-2021
Amsterdam Public Health
2015
University Hospital Southampton NHS Foundation Trust
2012-2015
University of Liège
2014
Hôpital Lariboisière
2014
Assistance Publique – Hôpitaux de Paris
2014
NIHR Southampton Biomedical Research Centre
2013-2014
Primary ciliary dyskinesia (PCD) is a heterogeneous inherited disorder caused by mutations in approximately 50 cilia-related genes. PCD genotype-phenotype relationships have mostly arisen from small case series because existing statistical approaches to investigating been unsuitable for rare diseases.We applied topological data analysis (TDA) approach investigate PCD. Data separate training and validation cohorts included 396 genetically defined individuals carrying pathogenic variants To...
Abstract Background Frailty and multimorbidity have been suggested as risk factors for severe COVID-19 disease. Aims We investigated, in the UK Biobank, whether frailty were associated with of hospitalisation COVID-19. Methods 502,640 participants aged 40–69 years at baseline (54–79 testing) recruited across during 2006–10. A modified assessment using Fried’s classification was generated from data. test results (England) available 16/03/2020–01/06/2020, mostly taken hospital settings....
To identify patient and general practice (GP) characteristics associated with emergency (unplanned) first admissions for cancer in secondary care. Patients who had a first-time admission primary diagnosis of during 2007/08 to 2009/10 were identified from administrative hospital data. We modelled the associations between odds these being unplanned various GP using national data sets, including Quality Outcomes Framework (QOF). There 639 064 patients cancer, 139 351 unplanned, 7957 practices....
Background: poor physical performance (PP) is known to be associated with disability, lower quality of life and higher mortality rates. Knee hip osteoarthritis (OA) might expected contribute PP, through joint pain restricted range movement. Both clinical self-reported OA are often used for large-scale community epidemiological studies. Objective: examine the relationships between knee PP in a large data set comprising cohorts from six European countries. Methods: total 2,942 men women aged...
the first quality of life questionnaire specific to sarcopenia, SarQoL®, has recently been developed and validated in French. To extend availability utilisation this questionnaire, its translation validation other languages is necessary.the purpose study was therefore translate SarQoL® into English validate psychometric properties new version.cross-sectional.Hertfordshire, UK.in total, 404 participants Hertfordshire Cohort Study, UK.the part articulated five stages: (i) two initial...
OBJECTIVE It is unclear whether people with and without diabetes equally benefitted from reductions in cardiovascular disease (CVD). We aimed to compare recent trends hospital admission rates for angina, acute myocardial infarction (AMI), stroke, percutaneous coronary intervention (PCI), artery bypass graft (CABG) among England. RESEARCH DESIGN AND METHODS identified all patients aged >16 years events England between 2004–2005 2009–2010 using national activity data. Diabetes-...
Abstract Objective Epidemiological studies of knee osteoarthritis (OA) have often used a radiographic definition. However, the clinical syndrome OA is influenced by broad range factors in addition to structural changes required for OA. Hence more recently several adopted or self-reported approach diagnosis rather than approach. The aim this study was investigate agreement between and diagnoses Design Data were available 199 men 196 women Hertfordshire Cohort Study (HCS), UK. Participants...
Abstract Invariant NKT cells (iNKT) are potent immunoregulatory T that recognize CD1d via a semi-invariant TCR (iNKT-TCR). Despite the knowledge of defective iNKT pool in several autoimmune conditions, including rheumatoid arthritis (RA), clear understanding intrinsic mechanisms, qualitative and structural changes human repertoire at earlier stages disease, is lacking. In this study, we compared structure function early RA patients with age- gender-matched controls. We analyzed phenotype ex...
Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors change joint space width (JSW). Methods. A total 559 men and women over the age 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2–3] were recruited to placebo arm SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral KL plain radiograph assessed at yearly followup up 3 years. In a...
Liver disease develops silently and presents late, with often fatal complications.
Significant correlation has been previously demonstrated between radiographic and clinical diagnoses of knee osteoarthritis (OA); however, the specific findings on examination that relate best to a diagnosis have not fully elicited. We aimed explore relationship symptoms physical with tibiofemoral patellofemoral OA. This study was based 409 individuals from Hertfordshire Cohort Study, born 1931 1939. Antero-posterior lateral radiographs were taken both knees. The presence OA defined...
The pattern of change in maternal bone turnover throughout pregnancy is poorly characterized. We investigated changes across a marker resorption, urinary C-terminal telopeptide type I collagen (CTX), the influence gestational vitamin D supplementation, and associations between CTX postnatal indices. MAVIDOS (the Maternal Vitamin Osteoporosis Study) randomized, double-blind, placebo-controlled trial 1000 IU cholecalciferol/d compared with placebo from 14 weeks gestation to birth. second-void...
To examine the effect of occupation on knee osteoarthritis (OA) and total replacement (TKR) in working-aged adults.
There are few data describing associations between dietary patterns and bone microarchitecture. This study investigated the relationship diet quality HRpQCT pQCT measures in older adults. Data were available for 184 men 166 women. Dietary collected at baseline (1998–2003) using an administered food frequency questionnaire. A 'prudent' score (PDS) was identified principal component analysis used as indicator of quality. images acquired follow-up 2012, from non-dominant distal radius tibia...