A5101647794- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Angiogenesis and VEGF in Cancer
- Ocular Oncology and Treatments
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Advanced Harmonic Analysis Research
- Rough Sets and Fuzzy Logic
- Cardiac and Coronary Surgery Techniques
- Educational Technology and Pedagogy
- Wnt/β-catenin signaling in development and cancer
- Cardiac Valve Diseases and Treatments
- Advanced Mathematical Physics Problems
- Connexins and lens biology
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lipid metabolism and disorders
- Ion Transport and Channel Regulation
- Cancer therapeutics and mechanisms
- HER2/EGFR in Cancer Research
- Chemokine receptors and signaling
Eye & ENT Hospital of Fudan University
2009-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Zhejiang Chinese Medical University
2024
Ruijin Hospital
2014-2024
Shanghai Jiao Tong University
2024
American Heart Association
2024
American College of Cardiology
2024
Fudan University
2009-2021
Ningxia Medical University
2021
Anhui Medical University
2014
To present new clinical features of juxtapapillary retinal capillary hemangiomas (JRCHs), assess the risk von Hippel-Lindau (VHL) disease, and explore genotype-phenotype correlations in patients with JRCH. Fifty JRCH were included. Multimodal imaging including optical coherence tomography angiography (OCTA), visual acuity, presence peripheral RCHs, affected lateralities, systemic evaluation for VHL underlying variants reviewed. Of 59 eyes, 48 had classic JRCHs, whereas 11 atypical JRCHs...
Purpose.: Diabetic retinopathy (DR) is one of the most serious complications diabetes and has become a major blinding eye disease, but its treatment remains unsatisfactory. The ERK1/2 signaling pathway been shown to participate in regulating secretion VEGF DR from our previous studies. role development provides target for treatment. Our present research focuses on Müller cells, source secretion, investigate regulation release diabetes. Methods.: Immunofluorescence was used observe...
Choroidal neovascularization (CNV) secondary to choroidal osteoma (CO) can cause profound visual loss, but detecting CNV and the tumor’s feeder vessels using traditional fluorescent angiography imaging is challenging. Newly developed TowardPi swept-source optical coherence tomography (SS-OCT) OCT (SS-OCTA) enable ultra-high resolution, enhanced penetration with longer wavelength (1060 nm), a rapid scan rate (400 KHz), reduced loss of signal strength increasing depth, 120° angular widefield...
Vascular endothelial growth factor (VEGF) is one of the major factors promoting diabetic retinopathy (DR). A better understanding signaling pathway in VEGF regulation clinical importance to identify more precise therapeutic targets for retinopathy. The ERK1/2 has been shown play a key role some oncoma and hematologic diseases by mediating release. This research was conducted determine whether also plays release DR development.One hundred Sprague-Dawley (SD) rats were induced diabetes...
To investigate the risk factors for persistent or recurrent central serous chorioretinopathy (CSC). Consecutive treatment-naïve CSC patients were included from January 2017 to October 2018. All asked complete questionnaires, addressing previously described development of CSC. Patients divided into two groups: those with acute CSC, who in first episode, spontaneous resolution subretinal fluid within 3 months, and no recurrence 1 year; remaining patients. In total, 138 enrolled: 20 (14.5%) 118...
To investigate the relationship between foveal outer nuclear layer (ONL) thickness in active and resolved phases of central serous chorioretinopathy (CSC), its possible association with optical coherence tomography (OCT) parameters. The medical records CSC patients treated half-dose photodynamic therapy (PDT) August 2011 October 2017 were reviewed. difference ONL at 12 m after PDT that before was analyzed, OCT parameters assessed using generalized linear models. Sixty-two included. mean 9.15...
Primary malignant pericardial mesothelioma (PMPM) is an extremely rare, highly lethal and often misdiagnosed tumor. We report a 60-year-old woman complaining of dry cough, shortness breath exertional dyspnea due to large effusion. The fluid volume declined after pericardiocentesis; analysis the revealed cells was negative for tuberculosis. Subsequently, patient developed compression superior vena cava constriction. patient's symptoms marginally improved partial pericardiectomy, diagnosis...
This study aimed to investigate the protein expression profile of vitreous humor (VH) from pathologic myopic retinoschisis (PMRS) patients with or without intravitreal antivascular endothelial growth factor (anti-VEGF) therapy. VH samples PMRS were subjected proteomic analysis. Clinical data, including visual acuity, refractive error, and axial length, recorded, fundus optical coherence tomography was performed. Seven enrolled: 3 as control group, coexisting choroidal neovascularization...
Purpose: To evaluate the morphological findings of outer retinal tubulations (ORTs) shown on multimodal imaging modalities in patients with choroidal osteoma. Methods: Nineteen eyes 17 osteoma underwent full clinical and assessments. Color fundus photography, spectral-domain optical coherence tomography (OCT), en face OCT were used to identify detect characteristics ORT structures, including shape, configuration, location, distribution fundus. Optical angiography was implemented as an assist...
Abstract Background Renal fibrosis is a progressive process associated with chronic kidney disease (CKD), contributing to impaired function. Active constituents in traditional Chinese herbs, such as emodin (EMO) and asiatic acid (AA), exhibit potent anti-fibrotic properties. However, the oral administration of EMO AA results low bioavailability limited accumulation. Additionally, while probiotics have been accepted for CKD treatment through gut microbiota modulation, significant challenge...
Purpose. To compare the functional and anatomical outcomes of one dose three loading doses followed by pro re nata (PRN) regimen in Chinese neovascular age-related macular degeneration (nvAMD) (including polypoidal choroidal vasculopathy (PCV)) patients. Methods. In this multicenter, prospective, open-label, controlled, 12-month study (ClinicalTrials.gov: NCT02810808), patients were randomized (1 : 1) to 1 + PRN (PRN group) or 3 (LD using intravitreal ranibizumab treatment. Best-corrected...
To characterize novel BEST1 mutations and the phenotype-genotype correlations in vitelliform macular dystrophy a Chinese population.Seventeen individuals affected by underwent detailed ophthalmic examinations, including best-corrected visual acuity test, slit-lamp biomicroscopy, fundus photography, spectral-domain optical coherence tomography, autofluorescence, fluorescein angiography, tomography angiography. Next-generation sequencing was used to screen 790 genes frequently involved common...
To evaluate the structural changes associated with visual acuity (VA) in patients idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. A retrospective study of 14 MT and 10 eyes from healthy individuals as age-matched controls was conducted. The medical records who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography OCT were reviewed. Central thickness (CMT), areas oedema ellipsoid zone (EZ)...
This research was aimed to investigate whether diabetic blood-stasis syndrome had a relationship with ERK1/2-VEGF signaling pathway in rat retina Müller cells and Traditional Chinese Drugs designed for promoting blood circulation remove stasis effectiveness retinopathy (DR) treatment.Immunofluorescence applied determine purity of cells. were stimulated by serum obtained from rats then treated Xuefu Zhuyu decoction. Western blot analysis, RT-PCR ELISA used measure the expression VEGF....
In this note, we consider a Fourier integral operator defined by \begin{align*} T_{\phi,a}f(x)=\int_{\mathbb{R}^{n}}e^{i\phi(x,\xi)}a(x,\xi)\widehat{f}(\xi)d\xi, \end{align*} where $a$ is the amplitude, and $\phi$ phase. Let $0\leq\rho\leq 1,n\geq 2$ or $0\leq\rho<1,n=1$ $$m_p=\frac{\rho-n}{p}+(n-1)\min\{\frac 12,\rho\}.$$ If belongs to forbidden H\"{o}rmander class $S^{m_p}_{\rho,1}$ $\phi\in \Phi^{2}$ satisfies strong non-degeneracy condition, then for any $\frac {n}{n+1}<p\leq 1$, can...
The guidelines recommend fractional flow reserve-guided coronary artery bypass grafting (CABG) during primary valve surgery without evidence. Quantitative ratio (QFR) is a novel angiography (CAG)-based reserve measurement. We aimed to compare the early clinical outcomes between QFR-guided and CAG-guided CABG in these patients.
Let u and \omega be weight functions. We shall introduce the weighted Morrey spaces L^{p,\kappa} (\omega) investigate sufficient condition necessary about 2-weighted boundedness of Hardy--Littlewood maximal operator.
By means of randomization, the concept randomized truth degree and logic pseudo-metric formulas in R0-logic with six-valued nonlinear valuation set are introduced. The metric space based on is also introduced it proved that new built concepts extensions corresponding quantitative set.