A5066294936- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Healthcare Policy and Management
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Arrest and Resuscitation
- Radiation Dose and Imaging
- COVID-19 Clinical Research Studies
- Thyroid and Parathyroid Surgery
- Glycosylation and Glycoproteins Research
- Frailty in Older Adults
- Antibiotic Resistance in Bacteria
- Patient-Provider Communication in Healthcare
- SARS-CoV-2 and COVID-19 Research
- Healthcare cost, quality, practices
- Cardiovascular Function and Risk Factors
- Global Health Workforce Issues
- Cerebrovascular and Carotid Artery Diseases
- Retinal Diseases and Treatments
- Mast cells and histamine
- Pain Management and Treatment
- Intensive Care Unit Cognitive Disorders
- ECG Monitoring and Analysis
Rutgers, The State University of New Jersey
2020-2024
Robert Wood Johnson University Hospital
2021-2024
Johnson University
2020-2024
Rutgers Cancer Institute of New Jersey
2023-2024
Hackensack Meridian Health
2023
Brunswick (United States)
2023
Rutgers Sexual and Reproductive Health and Rights
2021
Saint Barnabas Medical Center
2021
White Plains Hospital
2020
Hospital Universitario Virgen Macarena
2014
BackgroundTreatment of multidrug-resistant Acinetobacter baumannii (MDRAB) infection presents a challenge because the scarcity available options. Even though combination therapy (CT) is frequently used in clinical practice, data are needed to support its use instead monotherapy (MT).
Abstract The epithelial–mesenchymal transition (EMT) is an embryonic program frequently reactivated during cancer progression and implicated in invasion metastasis. Cancer cells can also acquire stem cell properties to self-renew give rise new tumors through the EMT. Inactivation of tumor suppressor PTEN has been shown induce EMT, but underlying molecular mechanisms are less understood. In this study, we reconstituted PTEN-deficient breast with wild-type mutant PTEN, demonstrating that...
BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAb) is a major source of nosocomial infections in Spain associated with the production OXA-58-like or OXA-24/40-like β-lactamase enzymes. We analysed plasmids carrying blaOXA-24/40-like gene CRAb isolates obtained decade apart.
The 2015 American Thyroid Association (ATA) guidelines recommended thyroid lobectomy (TL) as an alternative to total thyroidectomy (TT) for the surgical treatment of low-risk differentiated cancer. Increasing use TL has since been reported despite concerns increased risk disease recurrence and need reoperation. This study sought compare reoperation rates among patients who underwent initial or TT malignancy, characterize trends at centers based on operative volume, examine factors associated with
CREG1 is a small glycoprotein which has been proposed as transcription repressor, secretory ligand, lysosomal, or mitochondrial protein. This largely because of lack antibodies for immunolocalization validated through gain- and loss-of-function studies. In the present study, we demonstrate, using immunofluorescence microscopy, that mainly localized to endosomal-lysosomal compartment. Gain- analyses reveal an important role in both macropinocytosis clathrin-dependent endocytosis. also...
The tumor suppressor PTEN is essential for early development. Its lipid phosphatase activity converts PIP3 to PIP2 and antagonizes the PI3K–Akt pathway. In this study, we demonstrate that PTEN’s protein required epiblast epithelial differentiation polarization. This accomplished by reconstitution of PTEN-null embryoid bodies with mutants lack only or both activities. Phosphotyrosine antibody immunoprecipitation mass spectrometry were used identify Abi1, a core component WASP-family verprolin...
Establishing cardiopulmonary bypass remains critical to the successful repair of an acute type A aortic dissection. recent trend away from femoral arterial cannulation has occurred in part due concerns stroke risk retrograde perfusion brain. The purpose this study was determine if site for dissection impacts surgical outcomes.A retrospective chart review performed at Rutgers Robert Wood Johnson Medical School January 1st, 2011 March 8th, 2021. Of 135 patients included, 98 (73%) underwent...
Background The association between low socioeconomic status (SES) and worse surgical outcomes has become an emerging area of interest. Literature demonstrated that carotid artery stenting (CAS) poses greater risk postoperative complications, particularly stroke, than endarterectomy (CEA). This study aims to compare the impact SES on patients undergoing CAS vs. CEA. Methods National Inpatient Sample (NIS) was queried for CEA from 2010 2015. Patients were stratified by highest lowest median...
Background Octogenarians undergoing cardiac surgery have higher mortality than their younger counterparts. Objectives To determine if various risk factors the same effect on in octogenarians as patients. Methods The National Inpatient Sample data set from 2004 to 2014 was queried select patients aged 65 years and older who underwent either coronary artery bypass grafting (CABG), valvular heart (VHS), or both (CABG + VHS) within 10 days of hospital admission. were divided into two groups...
Background: The optimal cannulation site for repair of type A aortic dissection remains controversial. concern Malperfusion syndrome has initiated a national trend away from femoral to axillary artery and direct ascending cannulation. purpose this study was report single center experience with the dissection.
Minimally invasive heart valve surgery has previously been shown to be safe and feasible in obese patients. Within this population, we investigated the effect of obesity class on patient outcomes minimally aortic replacement (mini-AVR).A single-center retrospective cohort study consecutive patients with body mass indices (BMIs) who underwent mini-AVR between 2012 2020. Patients were stratified into three groups according Centers for Disease Control Prevention adult classifications: Class I...
The 5-year overall survival (OS) rate for patients with metastatic gastric cancer (mGC) is 5.3%. Surgery mGC controversial.We identified all who received chemotherapy using the National Cancer Database (2004-2015). Patients were grouped according to surgery of: (1) primary site (PS) only, (2) and distant sites (PDS), (3) only (DS), or (4) no (NS). A propensity score adjustment multivariate regression was used compare OS.Overall, 18,772 met inclusion criteria: PS (n = 962, 5.1%), PDS 380,...
Introduction: Frailty is an important predictor of clinical outcomes, but its contribution to resource utilization remains understudied. This study investigates the impact frailty on high (HRU) in patients undergoing Coronary Artery Bypass Graft Surgery (CABG). Methods: We reviewed data who underwent CABG at a single center between 04/2018 and 12/2019. A score (FS) was calculated using Essential Toolset (EFT). Patients were divided into two groups: Frail (FS ≥ 3/5) & Non-Frail <3/5)....
Patients who present to the emergency department (ED) with acute chest pain should receive a thorough history and exam rule out rare, life-threatening conditions, such as drug-induced aortic dissections (AD).A 34-year-old man of uncontrolled hypertension, smoking, "ecstasy" use presented ED an type A dissection (AD). Following surgery repair dissection, he developed compartment syndrome lower extremity requiring muscle excision neurolysis subsequent wound debridement procedures.Physicians...
CREG1 is a small glycoprotein in the endosomal-lysosomal system involved endocytic trafficking. It contains 3 N-linked glycosylation sites and highly expressed liver. To elucidate its physiological functions, we generated Creg1fl/fl mice using CRISPR technology. Whole-body hepatocyte-specific deletion of Creg1 was achieved by crossing with UBC-cre-ERT2 Albumin-cre mice, respectively. Both knockout developed elevated glycemia, glucose intolerance, resistance to blood glucose-lowering effect...
CREG1 is an endosomal-lysosomal protein which highly expressed in the liver. Hepatocyte-specific deletion of Creg1 mice causes insulin resistance and elevated glycemia. To test if nutritionally regulated, we fed for 10 weeks with a high-fat diet (HFD) progressively downregulated liver at both mRNA levels. The expression was restored after switch back to standard chow two weeks. diet-induced changes negatively correlated blood glucose Sequence analysis revealed enrichment CpG islands exon 1...