A5067715794- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Autophagy in Disease and Therapy
- Sepsis Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Total Knee Arthroplasty Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nosocomial Infections in ICU
- Spine and Intervertebral Disc Pathology
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Shoulder Injury and Treatment
- Surgical Simulation and Training
- Neurological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Epilepsy research and treatment
Fujian Provincial Hospital
2015-2025
Fujian Medical University
2012-2025
Fuzhou University
2024
West China Hospital of Sichuan University
2014-2020
Sichuan University
2014-2020
Yangzhou University
2017
Abstract Aims Dexmedetomidine (DEX) has been reported to alleviate hypoxic–ischemic brain damage (HIBD) in neonates. This study aimed investigate whether DEX improves cognitive impairment by promoting hippocampal neurogenesis via the BDNF/TrkB/CREB signaling pathway neonatal rats with HIBD. Methods HIBD was induced postnatal day 7 using Rice‐Vannucci method, and (25 μg/kg) administered intraperitoneally immediately after induction. The regulated administering TrkB receptor antagonist ANA‐12...
Toll-like receptor 4 (TLR4)-tumor necrosis factor 6 (TRAF6) signaling is activated in atherosclerosis (AS), inducing inflammatory mediators. Because miR-146a, a TLR4 microRNA (miRNA), can regulate during responses, this study investigated the effects of aerobic exercise on TLR4-targeted miRNAs AS. Apolipoprotein E-null mice fed high-fat diet for 12 weeks were separated into 3 groups: (i) no treatment (ii) statin (AD), or (iii) (AE). Plaques and foam cells observed untreated control groups,...
Utilizing liposomal bupivacaine (LB) for postoperative analgesia post-total knee arthroplasty (TKA) is prevalent. However, its effectiveness in pain control, specifically the parasacral ischial plane block (PIPB) post-TKA, remains unknown. This single-center, double-blinded, randomized controlled trial recruited patients scheduled unilateral TKA. Forty-five were randomly assigned a 1:1 ratio to receive 133 mg (Group A) or 266 B) LB using randomization method. The PIPB was assessed by...
Background . We conducted this prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of transcutaneous electric acupoint stimulation (TEAS) on quality recovery (QoR) and postoperative analgesia after gynecological laparoscopic surgery. Methods 74 American Society Anesthesiologists physical status (ASA) I or II patients undergoing surgery were randomly allocated TEAS control groups. The primary outcome was recovery, which assessed day before 24 h using a...
The aim was to verify that dexmedetomidine (DEX) can attenuate CLP‐induced intestinal injury via inhibition of inflammation. Male Sprague‐Dawley (SD) rats were randomly allocated into Sham group and the other three CLP model groups, in terms different treatments: placebo, DEX, yohimbine plus DEX (DEX + YOH) groups. Pathology examination conducted with HE stain. To identify differences among levels DAO, D‐lactate serum measured by spectrophotometry, TNF‐ α , IL‐1 β IL‐6 organ ELISA....
Abstract Introduction Perioperative neurocognitive disorders (PND) are common neurological complications after surgery. Diabetes mellitus (DM) has been reported to be an independent risk factor for PND, but little is known about its mechanism of action. Mammalian target rapamycin (mTOR) signaling crucial neuronal growth, development, apoptosis, and autophagy, the dysregulation mTOR leads disorders. The present study investigated whether can attenuate PND by inhibiting activating autophagy in...
Background: Hypoxic-ischemic brain damage (HIBD) is the main cause of neurological dysfunction in neonates. Olfactory cognitive function important for feeding, ability to detect hazardous situations and social relationships. However, only a few studies have investigated olfactory neonates with HIBD; furthermore, specific mechanisms involved are yet be elucidated. It has been reported that neurogenesis subventricular zone (SVZ) linked function. Recently, dexmedetomidine (DEX) shown provide...
Intraspinal anesthesia poses significant teaching challenges and inadequate resources, which ultimately limit students' opportunities for practice. To address this issue, we aimed to develop a virtual platform combined spinal-epidural that merges reality technology with haptic feedback technology, while assessing its educational impact learning outcomes.We utilized MIMICS, 3Ds MAX, UNITY 3D software perform reconstruction based on lumbar CT/MRI data from standard male volunteer. The...
High dosages of intra‑operative remifentanil are associated with opioid‑induced hyperalgesia (OIH). The aim the present study was to investigate effect combined dexmedetomidine and flurbiprofen axetil treatment on remifentanil‑induced hyperalgesia. Patients an American Society Anesthesiologists physical status I‑II who were diagnosed hysteromyoma scheduled for laparoscopic assisted vaginal hysterectomy (LAVH) randomly divided into three groups. Group (Group H, n=29) received remifentanil,...
Continuous peripheral nerve blocks are widely used for anesthesia and postoperative analgesia in lower limb surgeries. The authors aimed to develop a novel continuous sacral plexus block procedure during total knee arthroplasty.
Cerebral injury after cardiac arrest (CA)/cardiopulmonary resuscitation (CPR) has been implicated in the poor prognosis of CA survivors. This study was designed to evaluate impact melatonin on postresuscitation neurological outcomes and explore underlying mechanism. Sprague-Dawley rats were randomly assigned four groups: sham group, CPR pretreatment group (Pre-M) posttreatment (Post-M). For last 2 groups, daily gavage performed for 12 consecutive days before or 24 hours rat survival from...
Abstract Background Patients with hemorrhagic shock may develop emerging enterogenic sepsis due to damage the intestinal mucosal barrier and translocation of bacteria endotoxins caused by ischemic injury. Because dual effects anesthesia state shock, perioperative is even more rare insidious. Case presentation We reported a case 56-year-old man who underwent right hepatectomy for intrahepatic bile duct stones. Severe hemorrhage occurred during procedure hemodynamics neither improved nor...
Cognitive impairments induced by severe acute pancreatitis (SAP) are complications, for which there a lack of effective pharmacological treatment strategies. Berberine is an isoquinoline alkaloid extracted from the Chinese herb, Coptis rhizome, exhibits numerous biological effects on gastrointestinal disorders. However, berberine SAP‑induced cognitive remain unknown. The present study aimed to investigate associated with SAP. Wistar rats were randomly divided into Sham, Sham + berberine, SAP...
Pain management for older patients with hip fractures is challenging. This study aimed to investigate the effect of ultrasound-guided fascia iliac compartment block (UGFICB) using different doses nalbuphine in combination ropivacaine on preoperative analgesia fractures. In this multicenter randomized controlled trial, 280 elderly fracture were randomly allocated into four UGFICB groups (n = 70 each group): a group (30 mL 0.1% + 0.9% normal saline) and three plus (5, 10, 20 mg nalbuphine,...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Although total joint arthroplasty is the most effective procedures for end-stage arthritis, incidence of postoperative death and complications remains high. The association additional peripheral nerve blocks (PNBs) to routine spinal or general anesthesia with major adverse events (including mortality complication rates) in elective hip (THA) knee (TKA) has been subject inconclusive findings.