A5042860700- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Synthesis and Biological Activity
- Adipose Tissue and Metabolism
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Microtubule and mitosis dynamics
- Alkaloids: synthesis and pharmacology
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Genomics and Phylogenetic Studies
- Chemical Synthesis and Analysis
- Metabolism, Diabetes, and Cancer
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Innovations in Medical Education
- Medical Education and Admissions
- RNA Research and Splicing
- Corporate Identity and Reputation
- Cancer-related Molecular Pathways
- Respiratory Support and Mechanisms
Guangzhou University
2025
Fujian Provincial Hospital
2024
Fujian Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
University of Wisconsin–Madison
2016-2024
Chengdu Institute of Biology
2024
Chinese Academy of Sciences
2010-2024
University of Wisconsin Carbone Cancer Center
2016-2024
Zhejiang University
2018-2024
Versiti Blood Center of Wisconsin
2024
Knowledge on species’ breeding biology is the building blocks of avian life history theory. A review for current status knowledge at a global scale needed to highlight priority future research. We collected all available information three critical nesting parameters (clutch size, incubation period and nestling period) close 10 000 bird species in world identified taxonomic, geographic habitat gaps distribution biology. The results show that only one third extant are well known regarding...
The chemopreventive actions exerted by green tea are thought to be due its major polyphenol, (−)-epigallocatechin-3-gallate (EGCG). However, the low level of stability and bioavailability in body makes administering EGCG at doses unrealistic. We synthesized encapsulated chitosan-coated nanoliposomes (CSLIPO-EGCG), observed their antiproliferative proapoptotic effect MCF7 breast cancer cells. CSLIPO-EGCG significantly enhanced stability, improved sustained release, increased intracellular...
Abstract The relationship between creativity and executive control has long been controversial. Some researchers view creative thinking as a defocused process with little involvement, whereas others claim that plays vital role in thinking. In this study, we focused on one subcomponent of control, cognitive shifting, examined its by using latent variable analysis structural equation modeling. We also analyzed whether relation was mediated intelligence. results showed that: (a) shifting...
Porous tantalum (Ta) implants are highly corrosion resistant and biocompatible, they possess significantly better initial stability than that of conventional titanium (Ti) implants. During loading wear, Ta nanoparticles (Ta-NPs) were deposited on the surface a porous implant inevitably released come into direct contact with peri-implant osteoblasts. The wear debris may influence cell behavior stabilization. However, interaction Ta-NPs osteoblasts has not been clearly investigated. This study...
This study aims to enhance governmental decision-making by leveraging advanced topic modeling algorithms analyze public letters on the "People Call Me" online government inquiry platform in Zhejiang Province, China. Employing web scraping techniques, we collected publicly available letter data from Hangzhou City between June 2022 and May 2023. Initial descriptive statistical analyses text mining were conducted, followed using BERTopic algorithm. Our findings indicate that demands are chiefly...
The Holocene period spans some 11,700 years and has witnessed major climatic changes that have had a profound impact on the dynamics of European vegetation. This study begins by collating existing scholarly research. Combined with pollen data, temperature precipitation records, response vegetation to climate change during was investigated. Using datasets from sources such as Pangaea, AGU NOAA, we performed time series analyses, correlation analyses kernel density estimates explore these...
Utilizing liposomal bupivacaine (LB) for postoperative analgesia post-total knee arthroplasty (TKA) is prevalent. However, its effectiveness in pain control, specifically the parasacral ischial plane block (PIPB) post-TKA, remains unknown. This single-center, double-blinded, randomized controlled trial recruited patients scheduled unilateral TKA. Forty-five were randomly assigned a 1:1 ratio to receive 133 mg (Group A) or 266 B) LB using randomization method. The PIPB was assessed by...
Yin yang 1 (YY1) is a ubiquitous transcription factor and mammalian polycomb group protein (PcG) with important functions to regulate embryonic development, lineage differentiation, cell proliferation. YY1 mediates stable PcG-dependent transcriptional repression via recruitment of PcG proteins that catalyze histone modifications. Many questions remain unanswered regarding how cell- tissue-specificity achieved by proteins. Here, we demonstrate conditional knockout Yy1 in hematopoietic stem...
There is no widely accepted standard medical treatment for apocrine gland anal sac adenocarcinoma (AGASACA) in dogs. Targeted agents such as toceranib may be effective of AGASACA, but the number clinical reports investigating its efficacy limited.To evaluate AGASACA dogs, and to assess prognostic factors study population. Our hypothesis was that would provide a benefit dogs with AGASACA.Thirty-six client-owned either cytologic or histologic diagnosis were treated alone combination surgery,...
Abstract Yin Yang 1 (YY1) and structural maintenance of chromosomes 3 (SMC3) are 2 critical chromatin factors that mediate long-distance enhancer-promoter interactions promote developmentally regulated changes in architecture hematopoietic stem/progenitor cells (HSPCs). Although YY1 has functions promoting stem cell (HSC) self-renewal maintaining HSC quiescence, SMC3 is required for proper myeloid lineage differentiation. However, many questions remain unanswered regarding how interact with...
To evaluate a novel tetrahydroisoquinoline derivative YR4-42 as selective peroxisome proliferator-activated receptor γ (PPARγ) modulator (SPPARM) and explore its anti-diabetic effects in vitro vivo.Using two standard full PPARγ agonists rosiglitazone pioglitazone controls, the binding affinity transactivation action of were evaluated using biochemical cell-based reporter gene assays. The capacity to recruit coactivators was also assessed. on adipogenesis glucose consumption Ser273...
Abstract A hallmark of PcG transcriptional repression is stability the repressed state, although mechanism this unclear. The mammalian transcription factor YY1 can function as a protein in Drosophila resulting and correction phenotypic defects caused by mutation its homologue, Pleiohomeotic (PHO). To discern temporal requirements expression for these functions, to study stable vivo, we used larval wing imaginal disc system. We found that was needed transiently at day 3 or later embryonic...
A novel base-promoted cascade desalicyloylative dimerization of 3-(1-alkynyl)chromones to produce 2-alkynyl xanthones has been developed. This tandem process involves multiple reactions, such as Michael additions/cyclizations/desalicyloylation without a transition metal catalyst and inert atmosphere.
Ying Yang 1 (YY1) is a multifunctional Polycomb Group (PcG) transcription factor that binds to multiple enhancer binding sites in the immunoglobulin (Ig) loci and plays vital roles early B cell development. PcG proteins have important functions hematopoietic stem renewal YY1 only mammalian protein with DNA specificity. Conditional knock-out of mouse lineage results arrest at pro-B stage, dosage effects been observed various expression levels. To investigate impact elevated on hematopoetic...
Background Canine diffuse large B‐cell lymphoma (DLBCL) is a common and aggressive hematologic malignancy. The lack of conventional therapies with sustainable efficacy warrants further investigation novel therapeutics. Janus kinase (JAK) signal transducer activator transcription (STAT) pathways play important roles in the pathogenesis malignancies humans including DLBCLs. AZD1480 CYT387 are JAK1/2 inhibitors that have been used clinical trials for treating various cancers humans. No studies...
The Janus Kinase (JAK) and Signal Transducer Activator of Transcription (STAT) pathways play important roles in the pathogenesis diffuse large B cell lymphoma (DLBCL) humans, up-regulated STAT3 expression activity are associated with worse clinical outcome humans. No studies have evaluated JAK-STAT signaling pathway DLBCL dogs.STAT3 is deregulated dogs. We aim to assess expression, activation, cellular localization mitogen-activated protein kinase ERK1/2 dogs.Forty-three client-owned dogs...
We recently showed that host defense caerin peptides isolated from Australian frog tree were able to inhibit cervical cancer tumour cell growth in vitro. wished determine if radioactive isotope iodine-125 (125I) can be labeled 1.9 peptide and this is bioactive for breast cells treatment.The biological function of (1.1 1.9) investigated by vitro 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. The anti-cancer effect 125I was compared with unlabeled peptide. tissue...