A5101873285- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Lanthanide and Transition Metal Complexes
- Radiopharmaceutical Chemistry and Applications
- Medical Image Segmentation Techniques
- Brain Tumor Detection and Classification
- AI in cancer detection
- Quantum Dots Synthesis And Properties
- Advanced MRI Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Radiomics and Machine Learning in Medical Imaging
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Luminescence Properties of Advanced Materials
- Nanoparticles: synthesis and applications
- Neuroscience and Neural Engineering
- Computational Drug Discovery Methods
Nanyang Technological University
2016-2025
Mahatma Gandhi University
2025
Pravara Institute of Medical Sciences
2014-2016
Agency for Science, Technology and Research
2011-2015
Singapore Bioimaging Consortium
2009-2013
Stanford University
2006-2010
Clark University
2009
Jawaharlal Nehru University
2006
Cornell University
2002
Bhabha Atomic Research Centre
1974-1983
Transplanting the gut microbiota of pathogen-free mice into germ-free improves skeletal muscle mass and strength.
Although carbon nanoparticles or quantum dots (C-dots) have been studied extensively for a variety of applications (e.g., photocatalysis, metal ion sensing, antibacterial, cell labeling), greener synthetic method is highly indispensable. Herein, we report facile one-step hydrothermal carbonization approach the synthesis fluorescent blue/green C-dots using oyster mushroom (Pleurotus species). First, demonstrate application these as colorimetric sensor toxic ions detection such heavy Pb2+ with...
Gastrointestinal (GI) disorders are commonly associated with chronic conditions such as diabetes, obesity, and hypertension. Direct consequences obstipation or diarrhea opposite aspects of the irritable bowel syndrome, more indirectly, alteration appetite, feeling fullness, flatulence, bloatedness, eventually leading to altered absorption nutrients. Moreover, GI retention passage times have been recognized important factors in determining release site hence bioavailability orally...
We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd2O3:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow exhibit both emission magnetic characteristics. Tb-doped Yb/Er-codoped Gd2O3 down- up-conversion fluorescence respectively, also paramagnetism. Importantly, these codoped possess excellent characteristics, shown in their longitudinal...
Successive layers in convolutional neural networks (CNN) extract different features from input images. Applications of CNNs to detect abnormalities the 2D images or 3D volumes body organs have recently become popular. However, computer-aided detection diseases using deep CNN is challenging due absence a large set training medical images/scans and relatively small hard abnormalities. In this paper, we propose method for normalizing volumetric scans intensity profile samples. This aids by...
Reactive oxygen species (ROS) contain at least one atom and or more unpaired electrons include singlet oxygen, superoxide anion radical, hydroxyl hydroperoxyl free nitrogen radicals. Intracellular ROS can be formed as a consequence of several factors, including ultra-violet (UV) radiation, electron leakage during aerobic respiration, inflammatory responses mediated by macrophages, other external stimuli stress. The enhanced production is termed oxidative stress this leads to cellular damage,...
ObjectivesThe resistance of clinical isolates Leishmania donovani to sodium antimony gluconate (SAG), the mainstay treatment in Indian visceral leishmaniasis, has become a critical issue India. The present work investigates mechanism SAG parasites isolated from patients who are unresponsive SAG.
The fluorescent probes having complete spectral separation between absorption and emission spectra (large Stokes shift) are highly useful for solar concentrators bioimaging. In bioimaging application, NIR dyes have a greater advantage in tissue penetration depth compared to visible-emitting organic or inorganic quantum dots. Here we report the design, synthesis, characterization of an amphiphilic polymer, poly(isobutylene-alt-maleic anhyride)-functionalized near-infrared (NIR) IR-820 dye its...
Enzyme-responsive, hybrid, magnetic silica nanoparticles have been employed for multifunctional applications in selective drug delivery and intracellular tumor imaging. In this study, doxorubicin (Dox)-conjugated, enzyme-cleavable peptide precursors were covalently tethered onto the surface of uniform silica-coated through click chemistry. This enzyme-responsive nanoparticle conjugate demonstrated highly efficient Dox release upon specific enzyme interactions vitro. It also exhibits multiple...
Ultrasmall terbium ions (Tb3+) doped dysprosium oxide (Dy2O3) nanocrystals (NCs) of ∼3 nm diameter have been synthesized and applied as a single-phase dual modality contrast agent for high field magnetic resonance imaging (MRI) optical imaging. The NCs show excellent positive at 7.0 T MRI in phantom vivo mouse breast tumor model (MCF-7 cells) injected with NCs. In vitro confocal fluorescence microscopy images the staining cultured human bronchial epithelial cells (BEAS-2B) green fluorescent...
Adult stem cells are promising therapeutic reagents for skeletal regeneration. We hope to validate by molecular imaging technologies the in vivo life cycle of adipose-derived multipotent (ADMCs) an animal model injury. Primary ADMCs were lentivirally transfected with a fusion reporter gene and injected intravenously into mice bone injury or sham operation. Bioluminescence (BLI), [(18)F]FHBG (9-(fluoro-hydroxy-methyl-butyl-guanine)-micro-PET, [(18)F]Fluoride ion micro-PET micro-CT performed...