A5044239819- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Influenza Virus Research Studies
- Organ Transplantation Techniques and Outcomes
- Multiple Sclerosis Research Studies
- Renal Diseases and Glomerulopathies
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Organ and Tissue Transplantation Research
- HIV Research and Treatment
- Peripheral Neuropathies and Disorders
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Blood donation and transfusion practices
- Adolescent and Pediatric Healthcare
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Macrophage Migration Inhibitory Factor
- CAR-T cell therapy research
Inserm
2006-2017
Centre Hospitalier Universitaire de Nantes
2010-2017
Expression Génétique Microbienne
2008-2014
Université Libre de Bruxelles
2013
European Union
2011
Nantes Université
2010
Institut de Transplantation Urologie en Nephrologie
2006-2010
Identifying transplant recipients in whom immunological tolerance is established or developing would allow an individually tailored approach to their posttransplantation management. In this study, we aimed develop reliable and reproducible vitro assays capable of detecting renal recipients. Several biomarkers bioassays were screened on a training set that included 11 operationally tolerant recipients, recipient groups following different immunosuppressive regimes, undergoing chronic...
Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients minimized low-dose tacrolimus monotherapy within 24 wk of transplantation and subsequently maintained excellent graft function. After central venous administration, most M regs remained viable seen traffic from the pulmonary vasculature via blood liver, spleen, bone marrow. By 1 y posttransplantation, both displayed patterns peripheral gene expression converging upon IOT-RISET...
T-cell therapy after hematopoietic stem cell transplantation (HSCT) has been used alone or in combination with immunosuppression to cure hematologic malignancies and prevent disease recurrence. Here, we describe the outcome of patients high-risk/advanced stage malignancies, who received depleted (TCD) haploidentical-HSCT (haplo-HSCT) combined donor T lymphocytes pretreated IL-10 (ALT-TEN trial). IL-10-anergized cells (IL-10-DLI) contained regulatory type 1 (Tr1) specific for host...
We report on a pilot study investigating the feasibility of early immunosuppression withdrawal after liver transplantation (LT) using antithymocyte globulin (ATG) induction and rapamycin.LT recipients received 3.75 mg/kg per day ATG from days 0 to 5 followed by rapamycin-based immunosuppression. In absence acute rejection (AR), rapamycin was withdrawn month 4. Immunomonitoring included analysis peripheral T-cell phenotypes clonality, cytokine production in mixed lymphocyte reaction,...
Rare kidney allograft recipients enjoy unaltered graft function years after interruption of their immunosuppressive treatment. To assess the extent to which this state 'operational tolerance' (TOL) is specific and not result a global immunodeficiency, we analyzed response such patients following influenza vaccination. Hemagglutination inhibition titers frequency IFNgamma-secreting T cells were measured before 1 3 months The proportion healthy volunteers (HV) responding vaccine was...
Abstract The long‐term stability of renal grafts depends on the absence chronic rejection. As T cells play a key role in rejection processes, analyzing T‐cell repertoire may be useful for understanding graft function outcomes. We have therefore investigated power new statistical tool, used to analyze peripheral blood TCR repertoire, determining immunological differences group 229 stable transplant patients undergoing immunosuppression. Despite selecting according stringent criteria,...
Long-term survival is achieved in rat recipients by pre-graft donor-specific blood transfusion. We characterized the immune compartments long-term survivors and analyzed them for capacity to transfer tolerance protect against chronic rejection. Splenocytes spleen T cells from treated transferred graft 100% of secondary recipients. In contrast, only 50% whereas had no effect. An unaltered TCR repertoire, an increase suppressive CD4+CD25+ cells, a decrease antidonor T-cell proliferative...
There is high medical need for safe long-term immunosuppression monotherapy in kidney transplantation. Selective targeting of post-transplant alloantigen-(re)activated effector-T cells by anti-TNF antibodies after global T cell depletion may allow drug minimization, however, it unsolved what might be the best maintenance monotherapy.In this open, prospective observational single-centre trial, 20 primary deceased donor transplant recipients received 2x20 mg Alemtuzumab (d0/d1) followed 5...
Corticosteroid resistant idiopathic nephrotic syndrome (CR-INS) is a glomerulopathy that recurs after kidney transplantation in 30-50% of patients, suggesting the involvement systemic albuminuric factors, probably produced by activated T cells. We investigated peripheral T-cell selection and expansion before to identify characterize T-lymphocyte patterns potentially associated with INS recurrence. used combined qualitative quantitative assessment Vbeta mRNA alterations at level complementary...
Hutchinson, J. A.1; Riquelme, P.2; Brown, D. P.1; Sawitzki, B.3; Rehli, M.4; Tomiuk, S.5; Schröder, J.4; Sotnikova, A.6; Miqueu, P.7; Zuhayra, M.6; Oberg, H. H.6; Pascher, A.8; Lützen, U.6; Janen, U.5ß; Thaiss, F.9; Scheuermann, E.10; Henze, E.6; Chatenoud, L.11; Volk, H.12; Lechler, R. I.13; Wood, K. J.14; Kabelitz, D.6; Schlitt, J.15; Fändrich, F.6; Geissler, E. K.2 Author Information