A5045812083- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Pelvic and Acetabular Injuries
- Management of metastatic bone disease
- Shoulder and Clavicle Injuries
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Anesthesia and Pain Management
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Nerve Injury and Rehabilitation
- Hip and Femur Fractures
- Facial Trauma and Fracture Management
- Hip disorders and treatments
- Spinal Cord Injury Research
- Infectious Diseases and Tuberculosis
- Pain Mechanisms and Treatments
- Spinal Hematomas and Complications
- Radiation Dose and Imaging
- Bone Tissue Engineering Materials
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2013-2024
Universidade Federal de São Carlos
2024
Clinics Hospital of Ribeirão Preto
1998-2023
Beneficência Portuguesa de São Paulo
2018
Hospital São Paulo
2018
Toronto Western Hospital
2015
Universidade Brasil
2009-2013
Universidade Federal de Pernambuco
2013
Universidad San Pedro
2006-2011
In Brief Study Design. Prospective, multicenter international cohort. Objective. To evaluate outcomes of surgical decompression for cervical spondylotic myelopathy (CSM) at a global level. Summary Background Data. CSM is degenerative spine disease and the most common cause spinal cord dysfunction worldwide. Surgery increasingly recommended as preferred treatment strategy to improve neurological functional status quality life. The intervention have never been evaluated an Methods. Between...
<h3>Background</h3> In general, older patients with degenerative cervical myelopathy (DCM) are felt to have lower recovery potential following surgery due increased pathology, comorbidities, reduced physiological reserves and age-related changes the spinal cord. This study aims determine whether age truly is an independent predictor of surgical outcome provide evidence guide practice decision-making. <h3>Methods</h3> A total 479 DCM were prospectively enrolled in CSM-International at 16...
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective present study is to describe a simple animal model involving Wistar rats be used for research studies. Disc was confirmed classified by radiography, magnetic resonance histological evaluation. Adult male were anesthetized submitted percutaneous puncture with 20-gauge needle on levels 6-7 8-9 coccygeal vertebrae....
Study Design. Cross-sectional observational study on the relationship between degrees of disc degeneration and sagittal alignment in asymptomatic healthy individuals. Objective. This sought to determine whether spine subtype is related prevalence lumbar degeneration. Summary Background Data. Sagittal balance spinopelvic parameters might be risk factors for Methods. A total 70 participants (36 women 34 men) without regular physical activity were categorized according four subtypes proposed by...
Personalized care models are dominating modern medicine. These rooted in teaching future physicians the skill set to keep up with innovation. In orthopedic surgery and neurosurgery, education is increasingly influenced by augmented reality, simulation, navigation, robotics, some cases, artificial intelligence. The postpandemic learning environment has also changed, emphasizing online skill- competency-based incorporating clinical bench-top research. Attempts improve work–life balance...
Several biological events are controlled by Hedgehog (Hh) signaling, including osteoblast phenotype development. This study aimed at evaluating the gene expression profile of human mesenchymal stem cells (hMSCs) treated with Hh agonist, purmorphamine, focusing on signaling and differentiation. hMSCs from bone marrow were cultured in non-osteogenic medium or without purmorphamine (2 µM) for periods up to 14 days. Purmorphamine up-regulated mediators pathway, SMO, PTCH1, GLI1, GLI2. The...
Study Design. This study shows the first phase of validation a new model for realistic training on spine surgery, conducted from January 2014 to November 2015. Objective. To propose and validate tool neurosurgical education, associating virtual simulation (mixed reality), surgery. Summary Background Data. Surgical is relatively filed that has lot offer education. Training surgeon may take years hands-on procedures, increasing risk patient's safety. The development surgical platforms...
With the growing prevalence of lumbar spinal stenosis, endoscopic surgery, which incorporates techniques such as transforaminal, interlaminar, and unilateral biportal (UBE) endoscopy, is increasingly considered. However, patient selection criteria are debated among spine surgeons.
Foi estudado, em indivíduos normais, o valor angular da lordose lombar e a participação dos corpos vertebrais discos intervertebrais na sua composição. Foram avaliadas as radiografias coluna de 350 normais assintomáticos com idade variando 18 50 anos (média 29,0 ± 8,24), sendo 143 homens 207 mulheres. medidas curvatura lombossacra (L1S1) lombolombar (L1L5). As das curvaturas lombares seus componentes apresentaram grande variabilidade. observados valores médios -61° para -45° lombolombar....
Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water glycosaminoglycan content. Cannabidiol the main non-psychotropic component of Cannabis sativa with protective anti-inflammatory properties. However, possible therapeutic effects cannabidiol on intervertebral disc have not been investigated yet. The present study intradiscal injection coccygeal induced by needle puncture model using magnetic...
Endplate separations are defined as the presence of a space between hyaline cartilage and cortical bone adjacent vertebral body. This study evaluates endplate from body intervertebral discs verifies if separation is related to age spinal level. Groups were formed based on (20-40 41-85 years old) segment (T7-T8 L4-L5 segments). Histological analysis included assessment length endplates, number dimensions separations, orientation collagen fibers, in mid-sagittal slice. Two indexes created:...
Thoracolumbar fractures are most frequent along the spine, and surgical treatment is indicated for unstable fractures. Percutaneous minimally invasive surgery was introduced to reduce pain associated with open posterior approach morbidity of procedure by avoiding damage dissection paravertebral muscles. The goal this study compare thoracolumbar spine treated conventional percutaneous using similar types pedicle fixation systems. This designed as a multi-center, randomized controlled trial...
This in vivo study evaluated the osteogenic potential of two proteins, recombinant human bone morphogenetic protein-2 (rhBMP-2) and a protein extracted from natural latex (Hevea brasiliensis, P-1), compared their effects on defects when combined with carrier or collagen gelatin. Eighty-four (84) Wistar rats were divided into groups, without use gelatin, each these six treatment groups seven animals each. The were: (1) 5 microg pure rhBMP-2; (2) rhBMP-2/monoolein gel; (3) monoolein (4) P-1;...
Sagittal balance describes the optimal alignment of spine in sagittal plane, resulting from interaction between and lower limbs, via pelvis. Understanding has gained importance, especially last decade, because imbalance correlates directly with disability pain. Diseases that alter cause malalignment may trigger compensatory mechanisms. Certain radiographic parameters have been shown to be clinically relevant correlate clinical scores evaluation spinopelvic alignment. This article aims...
Methods for reliable evaluation of spinal cord (SC) injury in rats at short periods (2 and 24 h) after lesion were tested to characterize the mechanisms implicated primary SC damage. We measured physiological changes occurring several procedures producing injury, with particular emphasis on sensorimotor functions. Segmental suprasegmental reflexes 39 male Wistar weighing 250-300 g divided into three control groups that subjected a) anesthesia, b) dissection soft prevertebral tissue, c)...
In Brief Study Design. vitro biomechanical investigation of the screw-holding capacity. Objective. To evaluate effect repetitive screw-hole use on insertional torque and retentive strength vertebral system screws. Summary Background Data. Placement removal screws is sometimes necessary during surgical procedures in order to assess walls pilot hole. This procedure may compromise holding capacity implant. Methods. Screws with outer diameter measuring 5, 6, 7 mm were inserted into wood,...
ABSTRACT Decalcification of mineralized tissues is an essential step during tissue processing in the routine histopathology. The time required for complete decalcification, and effect decalcifier on cellular morphology are important parameters which influence selection decalcifying agents. In this study, we compared a solution (ETDA) composed both acid chelating agents to classical well‐known agent (EDTA). To purpose, optic density bone radiographs, residual calcium analysis, sample weight,...
Pain generator-based lumbar spinal decompression surgery is the backbone of modern spine care. In contrast to traditional image-based medical necessity criteria for surgery, assessing severity neural element encroachment, instability, and deformity, staged management common painful degenerative conditions likely be more durable cost-effective. Targeting validated pain generators can accomplished with simplified procedures associated lower perioperative complications long-term revision rates....