A5034720988- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Microscopic Colitis
- Cardiovascular Syncope and Autonomic Disorders
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Helicobacter pylori-related gastroenterology studies
- Assisted Reproductive Technology and Twin Pregnancy
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- HIV Research and Treatment
- Pregnancy and preeclampsia studies
- Mycobacterium research and diagnosis
- Eosinophilic Esophagitis
- Hepatitis B Virus Studies
- Cervical Cancer and HPV Research
- Psychosomatic Disorders and Their Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Meta-analysis and systematic reviews
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods in Clinical Trials
- Heavy Metal Exposure and Toxicity
- Liver Diseases and Immunity
- Occupational Health and Safety Research
University of Milan
2013-2024
Humanitas University
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2021
Luigi Sacco Hospital
2010-2020
ASST Fatebenefratelli Sacco
2018
Great Ormond Street Hospital
2015
University College London
2015
Hôpital Claude Huriez
2015
Ospedale Maggiore
2010
Hospital Médica Sur
2009
The American Thoracic Society (ATS) and European Respiratory (ERS) recommend that spirometry prediction equations be derived from samples of similar race/ethnicity. Malagasy do not exist. objectives this study were to establish for healthy adults, then compare measurements with published equations. We enrolled 2491 subjects aged 18–73 years (1428 males) June 2006 April 2008. attempted meet the ATS/ERS 2005 guidelines when performing forced expiratory spirograms. compared volume in 1 s...
The optimal emergency department (ED) evaluation of syncope is uncertain. Research reports from multiple countries suggest extensive practice variation, high costs, and questionable benefit associated with current approaches.1–5 Moreover, only a few the recommendations international guidelines deal ED management.6–8 For example, European Society Cardiology guidelines, which are most inclusive do not address management. This could be due to limited evidence on how stratify risk decide...
Whether the duration of maintenance treatment with azathioprine (AZA) affects outcome ulcerative colitis (UC) is unclear. We investigated clinical outcomes and any predictive factors after withdrawal AZA in UC.In this multicenter observational retrospective study, 127 Italian UC patients, who were steroid-free remission at time AZA, followed-up for a median 55 months or until relapse. The frequency relapse colectomy was analyzed according to demographic, clinical, endoscopic variables.After...
Randomized controlled trials (RCTs) that use the modified intention-to-treat (mITT) approach are increasingly being published. Such have a preponderance of post-randomization exclusions, industry sponsorship, and favourable findings, little is known whether in terms these items mITT different with respect to report standard intention-to-treat. To determine differences methodological quality, authors' conflicts interest, findings among "types" intention-to-treat, we undertook cross-sectional...
Study objectivesThere is limited evidence to guide the emergency department (ED) evaluation and management of syncope. The First International Workshop on Syncope Risk Stratification in Emergency Department identified key research questions methodological standards essential advancing science ED-based syncope research.MethodsWe recruited a multinational panel experts. A preconference survey priorities, which were refined during after conference through an iterative review...
Mesenteric adipose tissue hypertrophy is a frequent sonographic finding in Crohn's disease (CD). This study assessed its prevalence, the correlation with degree of clinical or biochemical activity disease, and impact on outcome CD patients.In all, 185 consecutive patients underwent bowel ultrasound to assess presence mesenteric fat alteration as well thickness echopattern wall, site extent CD, stenosis, fistulas, abscesses. Clinical parameters were also assessed. Multiple logistic regression...
To evaluate accuracy and cost of non-invasive diagnostic strategies including magnetic resonance imaging, intestinal ultrasonography, ileocolonoscopy video-capsule endoscopy in suspected Crohn's disease. A decision-analytic model was used to assess the costs low (25%), intermediate (50%) or high (75%) pre-test probability Based on published modalities Bayes' rule, we calculated post-test disease using different strategies, starting from ileocolonoscopy, ultrasonography resonance. Each...
Objectives To evaluate the risk factors for lopinavir/ritonavir (LPV/r)‐related liver enzyme elevation (LEE) in HIV antiretroviral‐experienced patients. Methods An open prospective observational study was carried out to analyse incidence and time of LEE development during LPV/r treatment, determine whether correlated with epidemiological, clinical biochemical data, immune virological profiles, concomitant hepatic diseases, antiretroviral therapy, or histological ultrasonography examination...
Aliment Pharmacol Ther 31 , 658–665 Summary Background Long‐term follow‐up studies of achalasia after pneumatic dilation, mostly retrospective, have shown variable results. Aim To examine the outcome dilation using a prospective programme. Methods One or two dilations (first treatment) in 77 patients to achieve stable (>1 year) remission and followed up with yearly clinical manometric assessments. Endoscopy, pH monitoring barium swallow were also performed. Results A total 69 achieved for...
Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome no acquired diseases (healthy [12 prepubertal, 13 pubertal]) 42 age- gender-matched controls (20 22 pubertal). Results showed that a complex impairment is present healthy individuals whom interferon gamma, interleukin (IL) IL-10 as well concentrations activation markers-bearing significantly augmented. Additionally, skewing of post-thymic lymphocyte...
Although a reduced prevalence of Helicobacter pylori infection has been observed in inflammatory bowel disease (IBD) patients, the clinical significance H. this setting remains unknown. The aim study was, therefore, to evaluate large series IBD patients and frequency gastroduodenal lesions those who agreed undergo upper GI endoscopy.Two hundred sixteen consecutive (123 with Crohn's (CD) 93 ulcerative colitis (UC)) had their anti-H. IgG titres measured. Two blood donors matched for age, sex,...
Objective: To evaluate the prevalence of HIV-related central nervous system (CNS) lesions (HIV-encephalitis and/or HIV-leukoencephalopathy: HIV-E/L) with and without concomitant opportunistic diseases in a large autopsy series, to correlate it changes antiretroviral treatment that have occurred since beginning epidemic. Methods: We reviewed 1597 consecutive autopsies HIV-positive patients performed between 1984 2000, divided into four time periods on basis therapeutic regimens available:...
Background: Two Pneumocystis jiroveci independent genomic regions, internal transcribed spacer (ITS) 1 and ITS2, dihydropteroate synthase (DHPS) gene have been used for typing a cohort of HIV-infected Italian patients with P. pneumonia (PcP). Methods: Bronchoalveolar lavage samples isolated from 207 adults were ITS DHPS genotyped by DNA sequencing restriction fragment length polymorphism analysis, respectively. Mutant cloned typed. Data on severity, treatment, outcome PcP obtained chart...