A5100651389- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Optical Coatings and Gratings
- Laser Material Processing Techniques
- Bioactive Natural Diterpenoids Research
- Plant Molecular Biology Research
- Fern and Epiphyte Biology
- Genetics and Neurodevelopmental Disorders
- Cell Image Analysis Techniques
- Autism Spectrum Disorder Research
- Solid State Laser Technologies
- Plant tissue culture and regeneration
- Ion-surface interactions and analysis
- Plant Gene Expression Analysis
- RNA Research and Splicing
- Aquaculture disease management and microbiota
- Plant-derived Lignans Synthesis and Bioactivity
- Transition Metal Oxide Nanomaterials
- Transgenic Plants and Applications
- Neural dynamics and brain function
- Metabolomics and Mass Spectrometry Studies
- Laser-Matter Interactions and Applications
Tsinghua University
2019-2024
Center for Excellence in Brain Science and Intelligence Technology
2021-2024
Sun Yat-sen University
2017-2024
Shandong University
2013-2024
Shanxi Normal University
2023-2024
Chinese Academy of Sciences
2011-2024
Shanghai Institute of Optics and Fine Mechanics
2011-2024
University Town of Shenzhen
2019-2024
Shandong University of Technology
2023
China Medical University
2022-2023
LncRNAs have been found to be involved in various aspects of biological processes. In this study, we aimed uncover the molecular mechanisms lncRNA EPB41L4A-AS1 regulating glycolysis and glutaminolysis cancer cells.
In comparison with general FISH for preparing probes in terms of time and cost, synthesized oligonucleotide (oligo hereafter) have many advantages such as ease design, synthesis, labeling. Low cost high sensitivity resolution oligo greatly simplify the procedure a simple, fast, efficient method chromosome identification. this study, we developed new multiplex to accurately efficiently distinguish wheat (Triticum aestivum, 2n = 6x, AABBDD) Thinopyrum bessarabicum (2n 2x 14, JJ) chromosomes....
Plant organ growth requires the proper transition from cell proliferation to expansion and differentiation. The CIN-TCP transcription factor gene TCP4 its post-transcriptional regulator microRNA319 play a pivotal role in this process. In study, we identified pathway which product of C2H2 zinc finger RABBIT EARS (RBE) regulates during Arabidopsis (Arabidopsis thaliana) petal development. RBE directly represses early stages development; contributes controlling primordia. We also found that...
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, causing defects of social interaction and repetitive behaviors. Here, we identify de novo heterozygous gene-truncating mutation the Sentrin-specific peptidase1 (SENP1) gene in people with ASD without delay. We find that Senp1
We report a grating solution for achieving broadband and polarization-independent properties that brings laser combining system to much higher power levels. The grating, with high-refractive-index-contrast bilayer ridge, was designed successfully fabricated based on high-power coatings, lithography, ion-beam etching technology. measured -1st order non-polarized reflective diffraction efficiency of the exceeds 98% over wavelength range 1.023-1.08 μm, highest value is 99.15%.
Summary Plant organs often grow into a genetically determined size and shape. How organ growth is finely regulated to achieve well defined pattern fascinating, but largely unresolved, question in plant research. We utilised the Arabidopsis petal study genetic control of growth, identify two closely related U‐box E3 ligases PUB25 PUB26 as important regulators by screening targets petal‐specific growth‐promoting transcription factor RABBIT EARS (RBE). showed that directly controlled RBE...
Loss of PTEN, the negative regulator PI3K activity, is frequent in glioblastomas (GBMs). However, role two major isoforms, p110α and p110β, PTEN-deficient gliomagenesis remains unknown. We show that GBM largely depends on for proliferation p110β migration. Genetic ablation either isoform delays tumor progression mice, but only ablating both isoforms completely blocks driven by concurrent Pten p53. BKM120 (buparlisib) treatment modestly prolongs survival mice bearing intracranial Pten/p53...
Abstract Long noncoding RNAs (lncRNAs) are >200 nt RNA transcripts without protein-coding potential. LncRNAs can be categorized into intergenic, intronic, bidirectional, sense, and antisense lncRNAs based on the genomic localization to nearby genes. The current CRISPR-based lncRNA knockout strategy works efficiently for distant from gene, whereas it causes perturbance inevitably due technical limitations. In this study, we introduce a novel strategy, BESST, by deleting DNA fragment...
Cephalotaxine (1), the major alkaloid isolated from Cephalotaxus species, has attracted considerable attention due to promising antitumor activity of several its derivatives and unique structural features. Herein we describe a highly efficient formal synthesis 1 employing [2,3]-Stevens rearrangement−acid lactonization sequence as key transformation readily available (3,4-dimethoxyphenyl)acetic acid, methyl prolinate, allyl bromide.
Two new secolignans, 3,4-trans-3-hydroxymethyl-4-[bis(4-hydroxyphenyl)methyl]butyrolactone (1) and 2,3-trans-3,4-trans-2-methoxy-3-hydroxymethyl-4-[bis(4-hydroxyphenyl)methyl]tetrahydrofuran (2), together with six known compounds, were isolated from the whole grass of Selaginella sinensis (Desv.) Spring. Their structures elucidated by NMR MS experiments.
Chromosome engineering is an important approach for generating wheat germplasm. Efficient development of chromosome aberrations will facilitate the introgression and application alien genes in wheat. In this study, zebularine, a DNA methylation transferase inhibitor, was successfully used to induce octoploid triticale cultivar Jinghui#1. Dry seeds were soaked zebularine solutions (250, 500, 750 μmol/L) 24 h, 500 μmol/L treatment tested three additional times, i.e., 12, 36, 48 h. All...
Abstract Background Aging and neurodegenerative diseases are typical metabolic-related processes. As a metabolism-related long non-coding RNA, EPB41L4A-AS has been reported to be potentially involved in the development of brain aging diseases. In this study, we sought reveal mechanisms Methods Human hippocampal gene expression profiles downloaded from Genotype-Tissue Expression database were analyzed obtain age-stratified differentially expressed genes; weighted correlation network analysis...
Two new dihydrobenzofuran lignanosides, (7R,8S)-4,3′,9′-trihydroxyl-3-methoxyl-7,8-dihydrobenzofuran-1′-propylneolignan-9-O-(6-O-syringoyl)-β-d-glucopyranoside, named lophanthoside B (1) and (7R,8S)-4,9,9′-trihydroxyl-3-methoxyl-7,8-dihydrobenzofuran-1′-propylneolignan-3′-O-β-d-glucopyranoside (2), an enantiomer of umbroside, along with four known lignans (3–6), were isolated from 50% acetone extract Rabdosia lophanthoides (Buch.-Ham.ex D.Don) Hara. Their structures elucidated by NMR MS experiments.
Diffraction gratings are an essential optical component of high-power, short-pulse lasers. The maximum output high-power pulsed lasers is always determined by laser resistance and this strongly dependent on the local near electric field intensity in grating structure. We presented a novel method reducing electric-field-enhancement metal-dielectric designing asymmetric ridge while maintaining high diffraction performance. Compared with common isosceles trapezoidal grating, got 0.04% reduction...