A5042479452- Biomedical Text Mining and Ontologies
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Natural Language Processing Techniques
- Bioinformatics and Genomic Networks
- Acute Myocardial Infarction Research
- Asthma and respiratory diseases
- Library Science and Information Systems
- Gene expression and cancer classification
- Pediatric health and respiratory diseases
- Semantic Web and Ontologies
- Adolescent and Pediatric Healthcare
- Immune Cell Function and Interaction
- Heart Failure Treatment and Management
- Data Quality and Management
- Childhood Cancer Survivors' Quality of Life
- Circadian rhythm and melatonin
- Inflammation biomarkers and pathways
- T-cell and B-cell Immunology
- Sepsis Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Cancer Immunotherapy and Biomarkers
- Mobile Health and mHealth Applications
The University of Western Australia
2023-2024
The Kids Research Institute Australia
2023-2024
Perth Children's Hospital
2023-2024
Princess Margaret Hospital for Children
2023-2024
South Australian Health and Medical Research Institute
2021
Women's and Children's Hospital
2020-2021
The University of Adelaide
2020
Flinders University
2014-2018
Women's and Children's Health Network
2015-2018
The University of Sydney
2012-2016
Sepsis involves aberrant immune responses to infection, but the exact nature of this dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers inflammation, which has been associated with pathophysiology sepsis, repeated exposure can also induce a suppressive effect known as endotoxin tolerance or cellular reprogramming. It proposed that might be immunosuppressive state was primarily observed during late-stage sepsis. However, relationship...
Abstract Novel therapies to target lung inflammation are predicted improve the lives of people with cystic fibrosis (CF) but specific antiinflammatory targets have not been identified. The goal this study was establish whether TLR5 signaling is key molecular pathway mediating in CF, and determine strategies inhibit can reduce damaging inflammatory response. innate immune responses were analyzed both airway epithelial cells primary PBMCs from CF patients matched controls. Additionally, 151...
Agricultural crop databases maintained in gene banks of the Consultative Group on International Research (CGIAR) are valuable sources information for breeders. These provide comparative phenotypic and genotypic that can help elucidate functional aspects plant agricultural biology. To facilitate data sharing within between these retrieval information, ontology (CO) database was designed to controlled vocabulary sets several economically important species.Existing public ontologies equivalent...
Introduction Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing a major burden on their families, global healthcare systems. It is now recognized dysfunctional airway epithelium plays central role in the pathogenesis recurrent wheeze, although underlying mechanisms still not fully understood. This prospective birth cohort aims bridge this knowledge gap by investigating influence intrinsic epithelial...
Abstract Preterm infants are uniquely susceptible to late‐onset sepsis that is frequently caused by the skin commensal Staphylococcus epidermidis . Innate immune responses, particularly from monocytes, a key protective mechanism. Impaired cytokine production preterm infant monocytes well described, but few studies have comprehensively assessed corresponding monocyte transcriptional response. responses in may be modulated inflammation such as prenatal exposure histologic chorioamnionitis...
Background Current treatments for respiratory infections are severely limited. Ethanol’s unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment if can be delivered safely to the airway by inhalation. Here, we explore safety, tolerability, pharmacokinetics of inhaled ethanol in phase I clinical trial. Methods The study was conducted as single-centre, open-label trial 18 healthy adult volunteers, six with no significant...
maxdLoad2 is a relational database schema and Java application for microarray experimental annotation storage. It compliant with all standards meta-data capture; including the specification of what data should be recorded, extensive use standard ontologies support exchange formats. The output from form acceptable submission to ArrayExpress repository at European Bioinformatics Institute. maxdBrowse PHP web-application that makes contents databases accessible via web-browser, command-line...
Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with inadequate IFN associated disease severity. Our objective was examine the prophylactic potential of administration limit viral transmission.A cluster randomised open label clinical trial undertaken determine effects pegylated IFNβ-1a on household transmission between December 3rd, 2020 and June 29th, 2021. Index cases were identified from...
Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.
Objective: The objective of this review is to identify, critically appraise and synthesize the available qualitative evidence understand experiences children, young adults their carers living with juvenile idiopathic arthritis in any setting. Introduction: Juvenile most common rheumatic disease childhood. Despite availability effective treatments, still has negative impacts on patients’ carers’ lives. Patients’ have been recognized as important measurement health status treatment...
// Thomas V. Guy 1,2 , Alexandra M. Terry Holly A. Bolton David G. Hancock Erhua Zhu Robert Brink 3 Helen McGuire Elena Shklovskaya 1,2,* and Barbara Fazekas de St Groth 1 T Cell Biology Laboratory, Centenary Institute of Cancer Medicine Biology, The University Sydney, NSW, Australia 2 Discipline Dermatology, Sydney Medical School, B Garvan Research, Darlinghurst, * These authors have contributed equally to this work Correspondence to: Shklovskaya, email: Groth, Keywords : melanoma,...