A5069438098- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrospinal fluid and hydrocephalus
- Cancer and Skin Lesions
- Cystic Fibrosis Research Advances
- Acute Lymphoblastic Leukemia research
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Genetic and rare skin diseases.
- Immunodeficiency and Autoimmune Disorders
- Hedgehog Signaling Pathway Studies
Karolinska Institutet
2007-2020
Karolinska University Hospital
2006-2016
We analyzed the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) over past 2 decades. Between 1992 and 2009, 953 patients were treated with HSCT, mainly for a hematologic malignancy. They divided according to 4 different time periods treatment: 1995, 1996 2000, 2001 2005, 2006 2009. Over years, many factors have changed considerably regarding patient age, diagnosis, disease stage, type donor, source, genomic HLA typing, dose, conditioning, treatment infections, use...
Abstract: Severe hemorrhagic cystitis (HC) may be a life‐threatening complication in allogeneic stem cell transplantation (SCT). In order to improve the strategies for prophylaxis and treatment, we retrospectively analyzed data on patients who underwent SCT at our center from 1990 through 2005. Patients with HC were identified database their medical charts reviewed. Grades 2–5 3–5 developed 109/834 (13.1%) 27/834 (3.2%), respectively. The frequency of decreased over time 18.0% 1990–1992 9.5%...
Background. The use of reduced intensity conditioning (RIC) regimens in allogeneic hematopoietic stem cell transplantation (HSCT) has increased over the past five years. Patients. In this study, involving 137 patients, we compared outcome after RIC patients receiving grafts from matched unrelated donors (MUD; n=74) and sibling (n=63). MUD groups were comparable regarding diagnosis, including solid tumors hematological malignancies, regimens. Results. Engraftment was successful most (88%),...
A retrospective analysis was performed of 118 patients with hematologic malignancies who received donor lymphocyte infusions (DLIs) after allogeneic stem cell transplantation (ASCT). Treatment either given because relapse (n = 44), molecular/cytogenetic 52), or other causes 22). Molecular in most cases based on leukemia lineage-specific chimerism analysis. Patients acute and myelodysplastic syndrome showed a 3-year survival 42% if DLI treatment molecular relapse, compared to 16% (P < .006)....
Cord blood (CB) as a source of stem cells has been successful addition to the field allogeneic cell transplantation (ASCT). The increased human leukocyte antigen (HLA) permissiveness CB grafts made it possible for more patients undergo treatment. drawback is that suffer from longer period compromised immunity. We analyzed T-cell receptor excision circles (TRECs), immunoglobulin G (IgG), and M (IgM) levels after cord (CBT) in 50 transplanted at our center. These immunological parameters were...
Background . Graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). We designed functional assay for assessment of individual risk acute GVHD. Study Design and Methods Blood samples were collected from patients donors before HSCT. Two groups seven each selected, one in which individuals developed GVHD grades II–IV none showed any clinical signs Peripheral blood mononuclear cells (PBMCs) isolated incubated mixed lymphocyte...
In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) the first 24 months after allogeneic stem cell transplantation. CD3(+) cells separated by direct antibody-coupled magnetic beads, followed DNA extraction according to a standard protocol. The δRec-ψJα signal joint TREC was measured real-time quantitative PCR. Patients grouped based on disease: chronic myeloid leukemia, lymphatic acute leukemia (AML),...
T-cell function is defective after allogeneic stem cell transplantation (ASCT). This has a significant clinical impact by increasing patients' susceptibility to infections, thus reducing survival. One way assess thymic output of T-cells measuring the level receptor excision circles (TRECs). retrospective study involved 210 patients with hematological malignancies. TREC levels in separated were measured at 6 time-points during first 24-months ASCT, using quantitative real-time PCR. The use...